Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers.

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Preparation of rat liver cells

1973 • 1,137 citations

CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL

1969 • 1,134 citations

Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.

1977 • 827 citations

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1977 • 753 citations

Clearance concepts in pharmacokinetics

1973 • 741 citations

Effects of unstirred layers on membrane phenomena.

1984 • 451 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

The partition of solutes between buffer solutions and solutions containing hyaluronic acid

1961 • 280 citations

Uptake of Taurocholic Acid into Isolated Rat‐Liver Cells

1975 • 275 citations

Determination of the mitochondrial protonmotive force in isolated hepatocytes.

1980 • 263 citations

Uptake of bile acids by perfused rat liver

1976 • 244 citations

Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes

1980 • 220 citations

Functional implications of liver cell heterogeneity

1981 • 201 citations

New concepts of mechanisms of hepatocyte bile formation.

1980 • 188 citations

Capillary Exchange Modeling

1970 • 185 citations

Enzymatic elimination of substrates flowing through the intact liver

1976 • 155 citations

Introduction to mathematical biology

1975 • 152 citations

Effect of Plasma Protein Binding on Elimination of Warfarin

1974 • 126 citations

Derivation of the equations that describe the effects of unstirred water layers on the kinetic parameters of active transport processes in the intestine

1977 • 117 citations

Carrier-mediated transport of ouabain in isolated hepatocytes.

1978 • 116 citations

Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion†

1989 • 112 citations

Cholic Acid Uptake into Isolated Rat Hepatocytes

1976 • 112 citations

Theoretic aspects of pharmacokinetic drug interactions

1977 • 83 citations

Enzymatic Histochemistry of the Liver

1959 • 75 citations

Effect of albumin on bile acid uptake by isolated rat hepatocytes is there a common bile acid carrier?

1976 • 53 citations

Kinetics of hepatic transport of 4-methylumbelliferone in rats. Analysis by multiple indicator dilution method

1987 • 52 citations

Effect of Nafenopin on the Uptake of Bilirubin and Sulfobromophthalein by Isolated Perfused Rat Liver

1982 • 49 citations

A quantitative study of fluorescein isothiocyanate-dextran transport in the microcirculation of the isolated perfused rat liver

1989 • 48 citations

‘Albumin-mediated transport phenomenon’ observed for ligands with high membrane permeability

1992 • 40 citations

Permeability of Interstitial Space of Muscle (Rat Diaphragm) to Solutes of Different Molecular Weights

1978 • 39 citations

Osmotic interaction of plasma proteins with interstitial macromolecules

1976 • 38 citations

Membrane-limited hepatic transport of the conjugative metabolites of 4‐methylumbelliferone in rats

1988 • 32 citations

Effects of unstirred Disse fluid, nonequilibrium binding, and surface-mediated dissociation on hepatic removal of albumin-bound organic anions

1985 • 24 citations

Unidirectional influx of glutamine and other neutral amino acids into liver of fed and fasted rat in vivo.

1977 • 22 citations

The effect of albumin on the uptake of bromosulfophthalein by isolated rat hepatocytes.

1985 • 15 citations

Analysis of multiple indicator dilution curves for estimation of renal tubular transport parameters

1985 • 15 citations

Dose-Dependent Hepatic Handling of l-Propranolol Determined by Multiple Indicator Dilution Method: Influence of Tissue Binding of l-Propranolol on Its Hepatic Elimination.

1993 • 15 citations

The Influence of Glucagon on the Hepatic Transport of Taurocholate in Isolated Perfused Rat Liver: Kinetic Analysis by the Multiple Indicator Dilution Technique.

1993 • 4 citations