Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

Handbook of experimental pharmacology

1971 • 526 citations

The Kidney: Physiology and Pathophysiology

1985 • 508 citations

Mechanisms of bile formation, hepatic uptake, and biliary excretion.

1984 • 375 citations

Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes.

1985 • 352 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Uptake of Taurocholic Acid into Isolated Rat‐Liver Cells

1975 • 275 citations

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

1986 • 267 citations

Conversion of biomembrane-produced energy into electric form. II. Intact mitochondria

1970 • 250 citations

Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier.

1984 • 225 citations

Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport

2007 • 210 citations

Handbook of Physiology, Section 6: The Gastrointestinal System

1993 • 206 citations

Intestinal permeation

1978 • 192 citations

THE PHARMACOLOGY OF ATRACURIUM: A NEW COMPETITIVE NEUROMUSCULAR BLOCKING AGENT

1981 • 191 citations

Renal tubule transport of organic cations

1981 • 156 citations

Bile‐Salt‐Binding Polypeptides in Plasma Membranes of Hepatocytes Revealed by Photoaffinity Labelling

1982 • 130 citations

Identification, Purification, and Partial Characterization of an Organic Anion Binding Protein from Rat Liver Cell Plasma Membrane

1980 • 119 citations

Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles.

1983 • 117 citations

Role of plasma membrane ligand-binding proteins in the hepatocellular uptake of albumin-bound organic anions

1987 • 116 citations

Carrier-mediated transport of ouabain in isolated hepatocytes.

1978 • 116 citations

Characterization of the bile acid transport system in normal and transformed hepatocytes. Photoaffinity labeling of the taurocholate carrier protein.

1983 • 115 citations

Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles.

1985 • 115 citations

alpha-Amanitin uptake into hepatocytes. Identification of hepatic membrane transport systems used by amatoxins.

1986 • 114 citations

Bile acid transport in cultured rat hepatocytes

1982 • 101 citations

Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling.

1984 • 99 citations

The Fate of Pancuronium Bromide in Man

1973 • 98 citations

Properties of (Na+ + K+)-activated ATPase in rat liver plasma membranes enriched with bile canaliculi

1975 • 97 citations

Effect of Na⊕ on Bile Acid Uptake by Isolated Rat Hepatocytes

1978 • 95 citations

Cell membrane potential and resistance in liver.

1978 • 93 citations

The Metabolism and Elimination of d-Tubocurarine-H3

1967 • 93 citations

Isolation and characterization of the putative canalicular bile salt transport system of rat liver.

1987 • 92 citations

Physicochemical and immunohistological studies of a sulfobromophthalein- and bilirubin-binding protein from rat liver plasma membranes.

1983 • 91 citations

Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver.

1987 • 88 citations

Active transport of quaternary ammonium compounds into bile

1963 • 87 citations

Identification of the hepatocyte Na+-dependent bile acid transport protein using monoclonal antibodies.

1988 • 80 citations

HEPATOBILIARY DISPOSITION OF VECURONIUM BROMIDE IN MAN

1986 • 77 citations

Hepatocellular uptake of sulfobromophthalein and bilirubin is selectively inhibited by an antibody to the liver plasma membrane sulfobromophthalein/bilirubin binding protein.

1986 • 76 citations

Comparative Pharmacokinetics and Dynamics of Vecuronium and Pancuronium in Anesthetized Patients

1986 • 73 citations

Photoaffinity labels as pharmacological tools

1984 • 70 citations

Functional reconstitution of the canalicular bile salt transport system of rat liver.

1988 • 69 citations

Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes

1985 • 67 citations

Structure-pharmacokinetics relationship of quaternary ammonium compounds

1984 • 66 citations

Effect of Na on bile acid uptake by isolated rat hepatocytes. Evidence for a heterogeneous system.

1978 • 65 citations

Isolation of an organic anion binding protein from rat liver plasma membrane fractions by affinity chromatography

1979 • 65 citations

Transport of drugs in isolated hepatocytes the influence of bile salts

1978 • 64 citations

Inhibition of Taurocholate and Ouabain Transport in Isolated Rat Hepatocytes by Cyclosporin A

1988 • 64 citations

Reconstitution in vitro of sulfobromophthalein transport by bilitranslocase

1982 • 64 citations

DISPOSITION KINETICS OF PANCURONIUM BROMIDE IN PATIENTS WITH TOTAL BILIARY OBSTRUCTION

1977 • 61 citations

Sodium ion‐coupled uptake of taurocholate by rat‐liver plasma membrane vesicles

1982 • 60 citations

Renal and Biliary Elimination of Vecuronium (ORG NC 45) and Pancuronium in Rats

1982 • 60 citations

Characterization of N-ethylmaleimide-sensitive proton pump in the rat kidney. Localization along the nephron.

1986 • 59 citations

Characterization of the anion transport system in hepatocyte plasma membranes.

1980 • 59 citations

A Scanning Electron Microscopic Study on Endothelial Cells and Kupffer Cells in Rat Liver Sinusoids

1975 • 57 citations

Uptake of Cortisol by Isolated Rat Liver Cells. A Phenomenon Indicative of Carrier-Mediation and Simple Diffusion

1976 • 57 citations

Biliary excretion of some diquaternary ammonium cations in the rat, guinea pig and rabbit

1973 • 57 citations

Further studies on bilitranslocase, a plasma membrane protein involved in hepatic organic anion uptake

1982 • 57 citations

Hepatic drug transport in the rat

1982 • 57 citations

Transport systems of isolated hepatocytes

1980 • 57 citations

Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles

1986 • 56 citations

Hydroxyl/bile acid exchange. A new mechanism for the uphill transport of cholate by basolateral liver plasma membrane vesicles.

1986 • 55 citations

Further characterization of membrane proteins involved in the transport of organic anions in hepatocytes Comparison of two different affinity labels: 4,4′-diisothiocyano-1,2-diphenylethane-2,2′-disulfonic acid and brominated taurodehydrocholic acid

1984 • 54 citations

Molecular weight as a factor in the excretion of monoquaternary ammonium cations in the bile of the rat, rabbit and guinea pig

1973 • 54 citations

Transport of dibromosulphthalein by isolated rat hepatocytes

1981 • 53 citations

Absorption and secretion of monoquaternary ammonium compounds by the isolated intestinal mucosa

1977 • 50 citations

Multispecific anion exchange in basolateral (sinusoidal) rat liver plasma membrane vesicles

1986 • 50 citations

Mechanisms of Bile Secretion and Hepatic Transport

1986 • 49 citations

Structure-pharmacokinetics relationship of quaternary ammonium compounds

1984 • 49 citations

Kinetics of the Elimination and Neuromuscular Blocking Effect of d-Tubocurarine in Man

1972 • 48 citations

Immunological studies of an organic anion-binding protein isolated from rat liver cell plasma membrane.

1985 • 47 citations

Comparative Pharmacokinetics of d-Tubocurarine and Metocurine in Man

1979 • 47 citations

Regulation of transmembrane electrical potential gradient in rat hepatocytes in situ

1987 • 46 citations

The comparative potency and pharmacokinetics of pancuronium and its metabolites in anesthetized man.

1978 • 46 citations

Purification and reconstitution of the bile acid transport system from hepatocyte sinusoidal plasma membranes

1986 • 46 citations

Choleresis and hepatic transport mechanisms

1975 • 44 citations

The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange.

1987 • 44 citations

The lack of active bile acid transport in AS-30 D ascites hepatoma cells

1978 • 43 citations

Excretion of Drugs in Bile

1971 • 43 citations

Some properties of the thiamine uptake system in isolated rat hepatocytes

1984 • 42 citations

Two systems are involved in the sulfobromophthalein uptake by rat liver cells: One is shared with bile salts

1981 • 41 citations

Driving forces in hepatocellular uptake of phalloidin and cholate

1984 • 41 citations

Competitive inhibition of the uptake of demethylphalloin by cholic acid in isolated hepatocytes

1981 • 40 citations

Cardiac Glycosides 1785–1985

1986 • 40 citations

Hepatic uptake and biliary excretion of organic cations—I

1984 • 39 citations

A PRELIMINARY INVESTIGATION OF THE RENAL AND HEPATIC EXCRETION OF GALLAMINE TRIETHIODIDE IN MAN

1978 • 39 citations

3′-Isothiocyanatobenzamido[3H]cholate, a new affinity label for hepatocellular membrane proteins responsible for the uptake of both bile acids and phalloidin

1984 • 38 citations

Curare-like agents: Relation between lipid solubility and transport into bile in perfused rat liver

1970 • 37 citations

Hepatic transport of mono and bisquaternary ammonium compounds

1970 • 35 citations

Current concepts on hepatic transport of drugs

1987 • 35 citations

Protective effect of anionic cholecystographic agents against phalloidin on isolated hepatocytes by competive inhibition of the phallotoxin uptake

1980 • 35 citations

Hepatic uptake and biliary excretion of d-tubocurarine and trimethyltubocurarine in the rat in vivo and in isolated perfused rat livers.

1976 • 35 citations

New Intravenous Anaesthetics and Neuromuscular Blocking Drugs

1987 • 34 citations

Identification of Different Transport Systems for Bile Salts in Sinusoidal and Canalicular Membranes of Hepatocytes

1987 • 33 citations

Common properties of hepatocellular uptake of cholate, iodipamide and antamanide, as distinct from the uptake of bromosulfophthalein

1983 • 33 citations

New insights into the renal secretion of drugs

1987 • 32 citations

Carrier-mediated transport of the organic cation procaine amide ethobromide by isolated rat liver parenchymal cells.

1978 • 32 citations

Localization of 14C-pancuronium by histo- and wholebody-autoradiography in normal and pregnant mice

1973 • 32 citations

The kinetics of sulfobromophthalein uptake by rat liver sinusoidal vesicles

1987 • 31 citations

Uptake of estrone, estradiol-17β and testosterone by isolated rat liver cells

1977 • 31 citations

Cholestatic steroid hormones inhibit taurocholate uptake into isolated rat hepatocytes

1977 • 31 citations

Hepatic transport of organic cations: Active uptake of a quaternary ammonium compound, procaine amide ethobromide, by rat liver slices

1963 • 30 citations

Concentrative transfer of an organic cation from blood into bile

1962 • 30 citations

The neurotoxins 1-methyl-4-phenylpyridinium and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine are substrates for the organic cation transporter in renal brush border membrane vesicles.

1987 • 30 citations

The Quinidine-Digoxin Interaction in Perspective

1983 • 30 citations

Organotropism by carrier-mediated transport

1982 • 30 citations

UPTAKE OF MORPHINE AND NALORPHINE BY ISOLATED RAT HEPATOCYTES

1978 • 29 citations

Uptake, accumulation and release of ouabain by isolated rat hepatocytes

1981 • 29 citations

Membrane Transport of Amphiphilic Compounds by Hepatocytes

1986 • 27 citations

Role of chloride on carrier-mediated transport of p- in rat renal basolateral membrane vesicles

1986 • 27 citations

Renal Pharmacology of Aminoglycoside Antibiotics1

2015 • 26 citations

EFFECTS OF HEPATIC UPTAKE OF VECURONIUM BROMIDE AND ITS PUTATIVE METABOLITES ON THEIR NEUROMUSCULAR BLOCKING ACTIONS IN THE CAT

1985 • 26 citations

Acinar redistribution and heterogeneity in transport of the organic cation rhodamine B in rat liver

1987 • 25 citations

Photoaffinity labeling of whole cells by flashed light: a simple apparatus for high-energy ultraviolet flashes

1986 • 25 citations

Distribution of quaternary ammonium compounds between particulate and soluble constituents of rat liver, in relation to their transport from plasma into bile

1972 • 25 citations

Choleresis and hepatic transport mechanisms

1978 • 25 citations

Uptake of estrone sulfate by isolated rat liver cells

1980 • 25 citations

MECHANISMS UNDERLYING THE PROLONGED DURATION OF ACTION OF MUSCLE RELAXANTS CAUSED BY EXTRAHEPATIC CHOLESTASIS

1981 • 24 citations

Identification of cyclosporin binding sites in rat liver plasma membranes, isolated hepatocytes, and hepatoma cells by photoaffinity labeling using [ 3 H]cyclosporin-diaziridine

1986 • 24 citations

Na+/H+ exchange: What, where and why?

1988 • 23 citations

Uptake of rifampicin by isolated rat liver cells. Interaction with sulfobromophthalein uptake and evidence for separate carriers

1979 • 23 citations

Transport functions of the liver. Lack of correlation between hepatocellular ouabain uptake and binding to (Na+ + K+)-ATPase

1985 • 23 citations

The influence of various bile salts and some cholephilic dyes on Na+, K+- and Mg2+-activated ATPase of rat liver in relation to cholestatic effects

1978 • 23 citations

The Relationship between Disposition and Duration of Action of a Congeneric Series of Steroidal Neuromuscular Blocking Agents

1977 • 23 citations

Binding of d-tubocurarine di (methyl-14C) ether iodide and other amines to cartilage, chondroitin sulfate and human plasma proteins.

1975 • 22 citations

A carrier-mediated transport system for benzylpenicillin in isolated hepatocytes

1985 • 22 citations

The effects of neuromuscular blocking agents on mitochondria—I

1960 • 21 citations

Clinical Pharmacokinetics of the Non-depolarising Muscle Relaxants

1981 • 21 citations

On the localisation of d-tubocurarine in rat liver lysosomes in vivo by electron microscopy and subcellular fractionation

1975 • 21 citations

Inhibition of ouabain-H3 uptake by liver slices and its excretion into the bile and by compounds having a steroid nucleus

1969 • 21 citations

Pharmacokinetics in Intravenous Anaesthetic Practice

1981 • 20 citations

Localization of d-tubocurarine in rat liver lysosomes

1977 • 20 citations

The Physicochemical Factor Required for the Biliary Excretion of Organic Cations and Anions

1974 • 20 citations

The cardiac glycoside sensitive step in the hepatic transport of the bisquaternary ammonium compound, hexafluorenium

1971 • 19 citations

Vesicular uptake system for the cation lucigenin in the rat hepatocyte.

1989 • 19 citations

DISTRIBUTION AND KINETICS OF 14 C-VECURONIUM IN RATS AND MICE

1987 • 19 citations

The excretion of hexafluorenium in man and rat

1971 • 19 citations

Hepatic transport mechanisms for bivalent organic cations

1990 • 18 citations

An Assessment of Statistics

1986 • 16 citations

Role of the bile acid transport system in hepatocellular ouabain uptake

1986 • 15 citations

Iodipamide uptake by rat liver plasma membrane vesicles enriched in the sinusoidal fraction: evidence for a carrier-mediated transport dependent on membrane potential

1986 • 14 citations

[Pharmacokinetics of diallyl-nor-toxiferine in man].

1972 • 14 citations

Metabolic fate of the short-acting peripheral neuromuscular blocking agent stercuronium in the rat, as related to its action

1971 • 14 citations

Properties of iodipamide uptake by isolated rat hepatocytes

1985 • 14 citations

PHARMACOKINETICS OF VECURONIUM IN MAN

1982 • 13 citations

Hepatic disposition of cationic drugs bound to asialoorosomucoid: lack of coendocytosis and evidence for intrahepatic dissociation.

1987 • 13 citations

Hepatic uptake and biliary excretion of N-acetyl procaine amide ethobromide in the rat

1973 • 13 citations

Studies on the pharmacokinetics of bis-quaternary ammonium compounds

1971 • 12 citations

Interaction of fusidates with bile acid uptake by isolated rat hepatocytes

1978 • 12 citations

Induction and inhibition of pinocytosis by aminoglycoside antibiotics

1984 • 12 citations

Pharmacokinetics and disposition of pipecuronium bromide in the cat.

1988 • 11 citations

Uptake of quaternary ammonium compounds into rat liver plasma membrane vesicles

1982 • 11 citations

Hepatic uptake and biliary excretion of organic cations—II

1984 • 11 citations

Metabolism of quaternary ammonium compoundS-I

1972 • 11 citations

INVOLVEMENT OF NUCLEOPHILES IN THE INACTIVATION OF ATRACURIUM

1987 • 11 citations

Autoradiographic Studies on the Distribution of Quaternary Ammonium Compounds. II. Distribution of <SUP>1</SUP>4C-Labeled Decamethonium, Hexamethonium and Dimethonium in Mice

1971 • 11 citations

The interaction of hepatocyte plasma membranes with an azide derivative of procaine

1977 • 11 citations

Ionic requirements for taurocholate transport in rat liver plasma membrane vesicles

1984 • 11 citations

Uptake and excretion of the quaternary ammonium compound deptropine methiodide in the isolated perfused rat liver

1972 • 10 citations

Intestinal Permeation of Organic Bases and Quaternary Ammonium Compounds

1984 • 10 citations

Transport rates of hepatic uptake and biliary excretion of an organic cation, acetyl procainamide ethobromide

1980 • 10 citations

The relation between structure and distribution of quaternary ammonium ions in mice and rats. Simple tetraalkylammonium and a series of m-substituted trimethylphenylammonium ions.

1986 • 9 citations

Hepatic Disposition and Biliary Excretion of the Organic Cations Thiazinamium and Thiazinamium Sulfoxide in Rats

1978 • 8 citations

Biopharmaceutical study of the hepato-biliary transport of drugs. V. Hepatic uptake and biliary excretion of organic cations.

1976 • 8 citations

Autoradiographic studies on the distribution of quaternary ammonium compounds. III. Distribution, excretion and metabolism of 14C-labeled pancuronium bromide in rats.

1974 • 8 citations

The effects of neuromuscular blocking agents on mitochondria—IV

1968 • 7 citations

Disposition of pipecurium bromide in rats.

1980 • 6 citations

Biliary excretion of nicotinamide riboside

1973 • 6 citations

Unequal Disposition of Enantiomers of the Organic Cation Oxyphenonium in the Rat Isolated Perfused Liver

1989 • 5 citations

Pharmacokinetic study on saturated hepato-biliary transport of acetyl procainamide ethobromide.

1981 • 5 citations

Influence of renal and hepatic function on pharmacodynamics and pharmacokinetics of non-depolarizing muscle relaxants

1987 • 5 citations

Effect of some medicinal plants on fertility of albino rats

1991 • 5 citations

Effect of acute renal failure on the disposition and elimination of [3H]N-acetyl procainamide ethobromide in the rat

1986 • 4 citations

Quinidine-induced reduction of the biliary excretion of digoxin in patients

1986 • 3 citations

Pharmacokinetics and disposition of chandonium iodide in rat.

1985 • 2 citations

TRANSPORT MECHANISMS FOR STEROIDAL CATIONIC DRUGS - RELATION BETWEEN HEPATOBILIARY TRANSPORT RATE AND SUBCELLULAR-DISTRIBUTION IN LIVER

1988 • 1 citations

Deleted Work

1955 • 0 citations