Differential Usage of Nuclear Export Sequences Regulates Intracellular Localization of the Dioxin (Aryl Hydrocarbon) Receptor

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The PAS Superfamily: Sensors of Environmental and Developmental Signals

2000 • 1,030 citations

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1999 • 1,011 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

1997 • 664 citations

CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless

1998 • 631 citations

Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor

1999 • 296 citations

Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor

1998 • 275 citations

Redox signalling and the control of cell growth and death

1995 • 256 citations

Remembrance of things PAS: regulation of development by bHLH–PAS proteins

1999 • 198 citations

The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor

2001 • 197 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

Redox-dependent Regulation of Nuclear Import of the Glucocorticoid Receptor

1999 • 178 citations

The Immunophilin-like Protein XAP2 Regulates Ubiquitination and Subcellular Localization of the Dioxin Receptor

2000 • 174 citations

Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

1993 • 161 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1

1999 • 141 citations

The PAS domain confers target gene specificity of DrosophilabHLH/PAS proteins

1997 • 138 citations

A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.

1994 • 134 citations

Role of the PAS Domain in Regulation of Dimerization and DNA Binding Specificity of the Dioxin Receptor

1998 • 113 citations

Protracted Nuclear Export of Glucocorticoid Receptor Limits Its Turnover and Does Not Require the Exportin 1/CRM1-Directed Nuclear Export Pathway

2000 • 99 citations

Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor

2000 • 81 citations

Analysis of the Complex Relationship between Nuclear Export and Aryl Hydrocarbon Receptor-Mediated Gene Regulation

2000 • 64 citations

A Mutation in the Aryl Hydrocarbon Receptor (AHR) in a Cultured Mammalian Cell Line Identifies a Novel Region of AHR That Affects DNA Binding

1997 • 62 citations

Xenobiotic-Responsive Element for the Transcriptional Activation of the Rat Cu/Zn Superoxide Dismutase Gene

1999 • 24 citations