DNA Methyltransferase Is a Downstream Effector of Cellular Transformation Triggered by Simian Virus 40 Large T Antigen

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 ^WAF1

1997 • 895 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

DNA methylation patterns Formation and function

1984 • 312 citations

De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)-Methyltransferase

1996 • 290 citations

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1993 • 255 citations

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.

1996 • 237 citations

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.

1990 • 237 citations

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency

1993 • 204 citations

Regulation of DNA Methylation by the Ras Signaling Pathway

1995 • 190 citations

DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture.

1986 • 185 citations

Inhibition of tumorigenesis by a cytosine–DNA, methyltransferase, antisense oligodeoxynucleotide

1997 • 171 citations

Expression of Antisense to DNA Methyltransferase mRNA Induces DNA Demethylation and Inhibits Tumorigenesis

1995 • 155 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

Growth regulation of mouse DNA methyltransferase gene expression

1991 • 137 citations

Regulation of the DNA Methyltransferase by the Ras-AP-1 Signaling Pathway

1995 • 136 citations

DNA methylation properties: consequences for pharmacology

1994 • 105 citations

New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase

1996 • 96 citations

SV40 T antigen induction and transformation in human fibroblast cell strains

1968 • 88 citations

Mouse DNA methylase: Methylation of native DNA

1979 • 86 citations

The DNA methylation machinery as a target for anticancer therapy

1996 • 84 citations

The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter.

1992 • 77 citations

Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia

1991 • 77 citations

Immortalization of primary mouse embryo fibroblasts with SV40 virions, viral DNA, and a subgenomic DNA fragment in a quantitative assay

1984 • 70 citations

An oligodendrocyte precursor cell line from rat optic nerve

1992 • 69 citations

5′ untranslated sequences modulate rapid mRNA degradation mediated by 3′ AU-rich element in v-/c-fosrecombinants

1992 • 44 citations

Antimycotic sterol biosynthesis inhibitors

1986 • 32 citations

Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts.

1993 • 24 citations