Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

Method for quantitative estimation of thermal thresholds in patients.

1976 • 777 citations

The measurement of pain; prototype for the quantitative study of subjective responses.

1957 • 496 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

STUDIES ON PAIN. OBSERVATIONS ON PAIN DUE TO LOCAL COOLING AND ON FACTORS INVOLVED IN THE “COLD PRESSOR” EFFECT

1941 • 328 citations

Measurements of human pressure-pain thresholds on fingers and toes

1989 • 293 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

Multiple opioid systems and pain

1986 • 286 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1988 • 210 citations

An experimental pain method sensitive to morphine in man: the submaximum effort tourniquet technique.

1966 • 204 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins

1990 • 193 citations

OBSERVATIONS ON EXTRADURAL MORPHINE ANALGESIA IN VARIOUS PAIN CONDITIONS

1980 • 172 citations

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1988 • 152 citations

Presence and formation of codeine and morphine in the rat.

1986 • 141 citations

Codeine O‐demethylation co‐segregates with polymorphic debrisoquine hydroxylation.

1989 • 139 citations

Selective reduction of second pain sensations by systemic morphine in humans

1986 • 136 citations

Morphine and other opiates from beef brain and adrenal.

1985 • 127 citations

Morphine and ibuprofen compared using the cold pressor test

1988 • 121 citations

Synthesis of the skeleton of the morphine molecule by mammalian liver

1987 • 108 citations

Chemical characterization and regulation of endogenous morphine and codeine in the rat.

1987 • 107 citations

The effect of quinidine on the analgesic effect of codeine

1992 • 95 citations

Morphine and codeine are endogenous components of human cerebrospinal fluid

1987 • 88 citations

Isolation of morphine from toad skin.

1985 • 86 citations

Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes.

1988 • 83 citations

Sparteine oxidation is practically abolished in quinidine‐treated patients.

1986 • 64 citations

Morphine formation from codeine in rat brain: A possible mechanism of codeine analgesia

1990 • 62 citations

Quantitative sensory examination in human epidural anaesthesia and analgesia: effects of lidocaine

1992 • 59 citations

Pain characterization in cancer patients and the analgetic response to epidural morphine

1991 • 59 citations

Evaluation of Pericranial Myofascial Nociception by Pressure Algometry. Reproducibility and Factors of Variation

1992 • 56 citations

Naloxone does not alter the perception of pain induced by electrical and thermal stimulation of the skin in healthy humans

1988 • 44 citations

Studies on the cutaneous pricking pain threshold in man. Circadian and circatrigintan changes.

1970 • 24 citations

Experimental Cutaneous Pain Thresholds and Tolerance in Clinical Analgesia with Epidural Morphine

1982 • 20 citations

Measurement of Human Pressure-Pain Thresholds on Fingers and Toes

1989 • 16 citations

Studies on the Cutaneous Pricking Pain Threshold in Man. Circadian and Circatrigintan Changes

1972 • 12 citations

Drug distribution in dog brain studied by positron emission tomography

1988 • 7 citations

Deleted Work

1955 • 0 citations