Studies of Genetic Differences in Response to Opioid Drugs

Density Estimation for Statistics and Data Analysis

2018 • 15,477 citations

Density Estimation for Statistics and Data Analysis

1400 • 8,320 citations

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System

1964 • 607 citations

RECOMBINANT-INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES

1971 • 595 citations

Alcohol tolerance and dependence

1980 • 419 citations

Opioid-Like Analgesia in Defeated Mice

1982 • 418 citations

Intracerebroventricular injections in mice

1986 • 388 citations

A CLASSIFICATION OF OPIATE RECEPTORS THAT MEDIATE ANTINOCICEPTION IN ANIMALS

1980 • 346 citations

THE MOUSE IN BIOMEDICAL RESEARCH

2005 • 334 citations

Estimation of Genetic Correlation: Interpretation of Experiments Using Selectively Bred and Inbred Animals

1990 • 322 citations

Studies on the antinociceptive action of α‐agonist drugs and their interactions with opioid mechanisms

1983 • 317 citations

Current Developments in Psychopharmacology

1981 • 275 citations

Origins of Inbred Mice

1978 • 263 citations

Novel opiate binding sites selective for benzomorphan drugs.

1981 • 225 citations

Genotype-dependent sensitivity and tolerance to morphine and heroin: Dissociation between opiate-induced running and analgesia in the mouse

1974 • 194 citations

Use of recombinant inbred strains to detect quantitative trait loci associated with behavior

1991 • 172 citations

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

1991 • 171 citations

Opiate receptors in mice: Genetic differences

1975 • 171 citations

Single-Locus Control of Saccharin Preference in Mice

1974 • 166 citations

Behavior Genetics: Principles and Applications

1984 • 151 citations

Recombinant inbred strains and bilineal congenic strains.

1981 • 146 citations

CXBK mice deficient in opiate receptors show poor electroacupuncture analgesia

1978 • 144 citations

Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains.

1977 • 138 citations

Autoradiographic analysis of mu1, mu2, and delta opioid binding in the central nervous system of C57BL/6BY and CXBK (opioid receptor-deficient) mice

1985 • 137 citations

Genetic Relationships Between Inbred Strains of Mice

1972 • 128 citations

Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse.

1969 • 122 citations

Binding selectivity profiles for ligands of multiple receptor types: Focus on opioid receptors

1987 • 120 citations

Addiction Liability of Albino Rats: Breeding for Quantitative Differences in Morphine Drinking

1967 • 107 citations

Inheritance of stress-induced analgesia in mice. Selective breeding study

1986 • 97 citations

Multiple opioid receptors criteria for identification and classification

1984 • 97 citations

A genetic analysis of the response to morphine in mice: Analgesia and running

1975 • 94 citations

SOURCES OF SUBLINE DIVERGENCE AND THEIR RELATIVE IMPORTANCE FOR SUBLINES OF SIX MAJOR INBRED STRAINS OF MICE

1978 • 91 citations

Strain differences in opiate receptors in mouse brain

1981 • 88 citations

Analgesic, locomotor and lethal effects of morphine in the mouse: Strain comparisons

1985 • 84 citations

Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and biochemical correlations.

1979 • 81 citations

Determinants of Substance Abuse

1985 • 78 citations

A genetic analysis of morphine-induced running and analgesia in the mouse

1975 • 77 citations

Morphine ingestion: Genetic control in mice

1977 • 73 citations

Genotype-dependent sensitivity to morphine: role of different opiate receptor populations

1980 • 73 citations

Differentiation of neurochemical basis of stress-induced analgesia in mice by selective breeding

1986 • 73 citations

Genetic dissociation of multiple morphine effects among C57BL/6J, DBA/2J and C3H/HeJ inbred mouse strains

1989 • 72 citations

Opioids and behavior: genetic aspects

1988 • 68 citations

Morphine sensitivity and tolerance: A genetic investigation in the mouse

1975 • 64 citations

Contributions of taste factors and gender to opioid preference in C57BL and DBA mice

1988 • 64 citations

Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.

1988 • 62 citations

Selective breeding for high and low levels of opiate-induced analgesia in mice

1983 • 58 citations

Stress-Induced Analgesia in the Mouse: Strain Comparisons

1985 • 57 citations

Do endorphins mediate acupuncture analgesia?

1978 • 50 citations

Genetically determined differences in the effects of morphine on mice

1975 • 47 citations

Opiate binding to cerebroside sulfate: A model system for opiate-receptor interaction

1975 • 45 citations

The Role of Genetics in Substance Abuse

1985 • 45 citations

Cerebroside and Sulphatide Deficiency in the Brain of “Jimpy Mice”, a Mutant Strain of Mice exhibiting Neurological Symptoms

1968 • 43 citations

Genetic analysis of susceptibility to morphine addiction in inbred mice.

1971 • 42 citations

Analgesia and motor activity elicited by morphine and enkephalins in two inbred strains of mice

1978 • 41 citations

C57BL/6J-bg J (beige) mice: Differential sensitivity in the tail flick test to centrally administered MU- and delta-opioid receptor agonists

1987 • 41 citations

Opioid receptor upregulation and supersensitivity in mice: Effect of morphine sensitivity

1989 • 40 citations

Genetic and biological markers in drug abuse and alcoholism.

1986 • 39 citations

Differential effects of opiate agonists-antagonists on morphine-induced hyperexcitability and analgesia in mice

1981 • 38 citations

Possible involvement of cerebroside sulfate in opiate receptor binding.

1978 • 38 citations

Genotype-dependent behavioral sensitivity to mu vs. kappa opiate agonists. I. Acute and chronic effects on mouse locomotor activity.

1984 • 36 citations

Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration

1988 • 35 citations

Inbred strain differences in morphine-induced analgesia with the hot plate assay: A reassessment

1990 • 35 citations

The role of control activity levels in the reported strain differences to the behavioral effects of drugs in mice

1989 • 33 citations

Physical dependence induced by the voluntary consumption of morphine in inbred mice

1990 • 32 citations

Evidence for the involvement of cerebroside sulfate in opiate receptor binding: Studies with Azure A and jimpy mutant mice.

1978 • 32 citations

Morphine analgesia, tolerance and dependence in mice from different strains and vendors

1977 • 30 citations

Effects of L- and D-amino acids on analgesia and locomotor activity of mice: their interaction with morphine

1980 • 29 citations

Use of Recombinant Inbred Strains to Assess Vulnerability to Drug Abuse at the Genetic Level

1991 • 28 citations

Inheritance of Stress-Induced Analgesia in Mice

1986 • 27 citations

Genotype-dependent behavioral sensitivity to mu vs. kappa opiate agonists. II. Antinociceptive tolerance and physical dependence.

1984 • 27 citations

Strain-dependent effects of shock-induced release of opioids: Dissociation between analgesia and behavioral seizures

1986 • 27 citations

Strain difference in the effects of morphine on the rectal temperature and respiratory rate in male mice

1986 • 25 citations

Selective breeding of mice for high and low swim analgesia: differential effect on discrete forms of footshock analgesia

1987 • 24 citations

Genetic influences on brain stimulation-produced analgesia in mice. I. Correlation with stress-induced analgesia

1989 • 21 citations

Selective breeding for levorphanol-induced antinociception on the hot-plate assay: commonalities in mechanism of action with morphine, pentazocine, ethylketocyclazocine, U-50488H and clonidine in mice.

1987 • 21 citations

Where are the mu Receptors That Mediate Opioid Analgesia? An Autoradiographical Study in the HAR and LAR Selection Lines

1991 • 20 citations

The analgesic defect of C57BL/6J-bgJ/bgJ (beige-J; Chediak-Higashi syndrome) mice transmitted by adoptive transfer of spleen cells to normal littermates

1988 • 20 citations

Strain difference in morphine-induced increase in plasma cyclic AMP and cyclic GMP levels in relation to locomotor activity in male mice

1982 • 18 citations

Lack of an opiate response to nitrous oxide in mice resistant to the activity-stimulating effects of morphine.

1982 • 18 citations

Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration

1990 • 17 citations

Genotype and test experience determine responsiveness to morphine

1978 • 17 citations

Pharmacogenetics of Drugs of Abuse

1989 • 17 citations

Effects of chlordiazepoxide-morphine combinations on spontaneous locomotor activity in three inbred strains of mice.

1980 • 16 citations

Enhanced responses to opiates produced by a single gene substitution in the mouse

1980 • 16 citations

Genetic control of opiate-induced locomotor activity in mice.

1978 • 16 citations

Behavioral Effects of Opiates: A Pharmacogenetic Analysis

1981 • 15 citations

[D-Pn5]enkephalin induced analgesia in the jimpy mouse: in vivo evidence for δ-receptor mediated analgesia

1987 • 15 citations

Genetic differences in opioids binding sites and in antinociceptice activities of morphine and ethylketocyclazocine

1983 • 15 citations

Cross-tolerance between D-amino acids and morphine in mice

1981 • 14 citations

The albino locus produces abnormal responses to opiates in the mouse

1980 • 13 citations

Components of the opioid withdrawal syndrome in mice are thermoregulatory responses

1989 • 13 citations

[3H][D-Ala2,NMePhe4,Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice

1988 • 13 citations

The sensitivity to noxious heat in relation to brain and liver opioid glucuronidation in inbred strains of mice

1989 • 13 citations

DSLET (D-Ser2-Leu5-Enkephalin-Thr6) produces analgesia on the hot plate by mechanisms largely different from DAGO and morphine-like opioids

1987 • 12 citations

Strain-dependent differences in responses to chronic administration of morphine: Lack of relationship to brain catecholamine levels in mice

1976 • 11 citations

Morphine metabolism in mouse brain.

1986 • 11 citations

Effects of the selective kappa-opioid receptor agonist U-50,488 on locomotor activity and passive avoidance behaviour in DBA/2 and C57BL/6 mice.

1987 • 10 citations

Genetic analysis of hypothermia induced by morphine in two strains of inbred mice

1987 • 10 citations

Effects of bremazocine on locomotor activity in DBA/2 and C57BL/6 mice.

1985 • 9 citations

Opposite effects of restraint on morphine analgesia and naloxone-induced jumping

1988 • 8 citations

Genetic determinants of responses to drugs of abuse: An evaluation of research strategies.

1984 • 7 citations

Genetic markers of drug abuse in mouse models.

1986 • 5 citations

Deleted Work

1955 • 0 citations