The genetics of pain and pain inhibition.

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

1989 • 5,285 citations

Introduction to Quantitative Genetics

1962 • 3,615 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

The formalin test: an evaluation of the method

1992 • 2,414 citations

A genetic map of the mouse suitable for typing intraspecific crosses.

1992 • 1,114 citations

Pain measurement: an overview

1985 • 1,084 citations

Enhanced Aggressive Behavior in Mice Lacking 5-HT _1B Receptor

1994 • 823 citations

Mouse genetics: concepts and applications

1995 • 791 citations

Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa

1979 • 651 citations

RECOMBINANT-INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES

1971 • 595 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

Intrinsic Mechanisms of Pain Inhibition: Activation by Stress

1984 • 528 citations

Endogenous and Exogenous Opiate Agonists and Antagonists

1980 • 442 citations

PAIN IN MEN WOUNDED IN BATTLE

1946 • 416 citations

Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

1995 • 416 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

THE MOUSE IN BIOMEDICAL RESEARCH

2005 • 334 citations

Estimation of Genetic Correlation: Interpretation of Experiments Using Selectively Bred and Inbred Animals

1990 • 322 citations

Individual variability in the response to different opioids: report of five cases

1992 • 245 citations

Impact of environmental and genetic factors on codeine analgesia

1991 • 235 citations

NOT ‘INDIFFERENCE TO PAIN’ BUT VARIETIES OF HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY

1983 • 212 citations

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1988 • 210 citations

Genotype-dependent sensitivity and tolerance to morphine and heroin: Dissociation between opiate-induced running and analgesia in the mouse

1974 • 194 citations

Heritability of symptoms in an experimental model of neuropathic pain

1990 • 178 citations

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

1991 • 171 citations

Opiate receptors in mice: Genetic differences

1975 • 171 citations

The Genetic Basis of Alcohol and Drug Actions

1991 • 154 citations

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

1996 • 154 citations

Opioid and Nonopioid Swim Stress-Induced Analgesia: A Parametric Analysis in Mice

1996 • 150 citations

Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains.

1977 • 138 citations

Autoradiographic analysis of mu1, mu2, and delta opioid binding in the central nervous system of C57BL/6BY and CXBK (opioid receptor-deficient) mice

1985 • 137 citations

Familial pain models: the relationship between family history of pain and current pain experience

1985 • 135 citations

CONGENITAL INSENSITIVITY TO PAIN

1973 • 134 citations

Genetic Relationships Between Inbred Strains of Mice

1972 • 128 citations

Familial models for chronic pain

1984 • 124 citations

THE OPTIMAL DOSE OF MORPHINE

1954 • 116 citations

An overview of neurobiological comparisons in mouse strains

1980 • 111 citations

Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor

1994 • 110 citations

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

1995 • 101 citations

Inheritance of stress-induced analgesia in mice. Selective breeding study

1986 • 97 citations

A genetic analysis of the response to morphine in mice: Analgesia and running

1975 • 94 citations

Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes

1993 • 93 citations

Differential Effects of Morphine and Naltrexone on the Antibody Response in Various Mouse Strains

1992 • 91 citations

Autotomy following nerve injury: Genetic factors in the development of chronic pain

1980 • 91 citations

N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. II. Comparison across three swim-stress paradigms in selectively bred mice

1992 • 89 citations

Strain differences in opiate receptors in mouse brain

1981 • 88 citations

Morphine and codeine are endogenous components of human cerebrospinal fluid

1987 • 88 citations

Interpreting studies that compare high- and low-selected lines on new characters

1989 • 87 citations

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

1993 • 83 citations

Genetic influences in opioid analgesic sensitivity in mice

1991 • 80 citations

Chromosome Mapping of Gene Loci Affecting Morphine and Amphetamine Responses in BXD Recombinant Inbred Micea

1992 • 79 citations

Differentiation of neurochemical basis of stress-induced analgesia in mice by selective breeding

1986 • 73 citations

Naloxazone and pain-inhibitory systems: evidence for a collateral inhibition model

1982 • 72 citations

Colonic bead expulsion time in normal and μ-opioid receptor deficient (CXBK) mice following central (ICV) administration of μ- and δ-opioid agonists

1987 • 70 citations

Opioids and behavior: genetic aspects

1988 • 68 citations

Morphine sensitivity and tolerance: A genetic investigation in the mouse

1975 • 64 citations

Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.

1988 • 62 citations

Correlation of genetic differences in endorphin systems with analgesic effects of D-amino acids in mice

1979 • 61 citations

Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: Some methodological implications for RI strain analysis

1992 • 59 citations

Selective breeding for high and low levels of opiate-induced analgesia in mice

1983 • 58 citations

Stress-Induced Analgesia in the Mouse: Strain Comparisons

1985 • 57 citations

Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains.

1993 • 57 citations

Manipulating the Genome by Homologous Recombination in Embryonic Stem Cells

1992 • 56 citations

The effects of swimming in mice on pain perception and sleeping time in response to hypnotic drugs

1980 • 56 citations

Dorsal raphe stimulation reduces responses of parafascicular neurons to noxious stimulation 1

1983 • 56 citations

Reduced saccharin preference in CXBK (opioid receptor-deficient) mice

1988 • 55 citations

Murine Chromosomal Location of the μ and κ Opioid Receptor Genes

1994 • 53 citations

μ-Opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia

1994 • 50 citations

One or two genetic loci mediate high opiate analgesia in selectively bred mice

1995 • 48 citations

Footshock-induced analgesia: Its opioid nature depends on the strain of rat

1985 • 47 citations

Genetically determined differences in the effects of morphine on mice

1975 • 47 citations

Blockade of δ-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice

1994 • 46 citations

N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. I. Comparison of opiate receptor-deficient and opiate receptor-rich strains of mice

1991 • 42 citations

C57BL/6J-bg J (beige) mice: Differential sensitivity in the tail flick test to centrally administered MU- and delta-opioid receptor agonists

1987 • 41 citations

Systemic administration of naloxone produces analgesia in BALB/c mice in the formalin pain test

1988 • 40 citations

Opioid receptor upregulation and supersensitivity in mice: Effect of morphine sensitivity

1989 • 40 citations

Congenital insensitivity to pain and the “morphine-like” analgesic system

1978 • 39 citations

Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration

1988 • 35 citations

Evidence for the involvement of cerebroside sulfate in opiate receptor binding: Studies with Azure A and jimpy mutant mice.

1978 • 32 citations

Morphine analgesia and tolerance in mice selectively bred for divergent swim stress-induced analgesia

1994 • 31 citations

Antagonism of the non-opioid component of ethanol-induced analgesia by the NMDA receptor antagonist MK-801

1993 • 31 citations

Levorphanol and swim stress-induced analgesia in selectively bred mice: evidence for genetic commonalities

1993 • 30 citations

Morphine analgesia, tolerance and dependence in mice from different strains and vendors

1977 • 30 citations

The role of mu1 receptor in physical dependence on morphine using the mu receptor deficient CXBK mouse

1992 • 27 citations

Dorsal raphe and nociceptive stimulations evoke convergent responses on the thalamic centralis lateralis and medial prefrontal cortex neurons

1989 • 26 citations

Genetic differences in opiate receptor concentration and sensitivity to ethanol's effects

1989 • 25 citations

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker

1993 • 24 citations

Selective breeding of mice for high and low swim analgesia: differential effect on discrete forms of footshock analgesia

1987 • 24 citations

Oligogenic determination of morphine analgesic magnitude: A genetic analysis of selectively bred mouse lines

1995 • 23 citations

Familial Trigeminal Neuralgia: Case Report

1989 • 22 citations

Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the μ-opioid receptor deficient CXBX mouse

1992 • 22 citations

Genetic influences on brain stimulation-produced analgesia in mice. I. Correlation with stress-induced analgesia

1989 • 21 citations

Selective breeding for levorphanol-induced antinociception on the hot-plate assay: commonalities in mechanism of action with morphine, pentazocine, ethylketocyclazocine, U-50488H and clonidine in mice.

1987 • 21 citations

Strain-dependent differences in responsiveness of mice to nitrous oxide (N2O) antinociception

1993 • 21 citations

Genetic Modulations of Stress‐Induced Analgesia in Mice^a

1986 • 20 citations

Where are the mu Receptors That Mediate Opioid Analgesia? An Autoradiographical Study in the HAR and LAR Selection Lines

1991 • 20 citations

The analgesic defect of C57BL/6J-bgJ/bgJ (beige-J; Chediak-Higashi syndrome) mice transmitted by adoptive transfer of spleen cells to normal littermates

1988 • 20 citations

Mechano- and thermo-sensitivity in rats genetically prone to developing neuropathic pain

1991 • 20 citations

Tolerance and cross-tolerance with morphine in mice selectively bred for high and low stress-induced analgesia

1991 • 18 citations

Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration

1990 • 17 citations

Genetic influences on the control of nociceptive responses & precipitated abstinence in mice.

1982 • 17 citations

Pharmacogenetics of Drugs of Abuse

1989 • 17 citations

Adrenalectomy and dexamethasone differentially affect postswim antinociception in mice selectively bred for high and low stress-induced analgesia

1987 • 15 citations

Genetic differences in opioids binding sites and in antinociceptice activities of morphine and ethylketocyclazocine

1983 • 15 citations

Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.

1993 • 14 citations

Analgesic effect of μ-and κ-opioid agonists in beige and CXBK mice

1991 • 14 citations

Potentiation of swim analgesia by D-amino acids in mice is genotype dependent

1990 • 13 citations

[3H][D-Ala2,NMePhe4,Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice

1988 • 13 citations

Etonitazene-induced antinociception in μ1 opioid receptor deficient CXBK mice: Evidence for a role for μ2 receptors in supraspinal antinociception

1994 • 13 citations

Congenital Insensitivity to Pain

1991 • 12 citations

DSLET (D-Ser2-Leu5-Enkephalin-Thr6) produces analgesia on the hot plate by mechanisms largely different from DAGO and morphine-like opioids

1987 • 12 citations

Opioid μ-deficient CXBK mouse and the role of μ1-receptors in electrically induced convulsions

1992 • 11 citations

Correlation between magnitude and opioid mediation of stress-induced analgesia: individual differences and the effect of selective breeding.

1990 • 10 citations

Genetic factors in conditioned tolerance to the analgesic effects of etonitazene

1993 • 10 citations

Substance P modulation of DAMGO binding in the brain of CXBK and Swiss-Webster mice

1990 • 5 citations