Opioids and behavior: genetic aspects

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Endogenous Opioids: Biology and Function

1984 • 1,223 citations

Social Factors in Psychopathology: Stress, Social Support, and Coping Processes

1985 • 1,099 citations

Organization of Endogenous Opiate and Nonopiate Pain Control Systems

1982 • 793 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

β-Endorphin Is Associated with Overeating in Genetically Obese Mice ( ob / ob ) and Rats ( fa / fa )

1978 • 474 citations

Endogenous Peptides and Learning and Memory Processes

1981 • 454 citations

Opioid modulation of appetite

1983 • 452 citations

Opioid-Like Analgesia in Defeated Mice

1982 • 418 citations

κ and δ-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release

1984 • 275 citations

The Neurobiology of opiate reward processes

1983 • 216 citations

Endogenous opioid peptides and regulation of drinking and feeding

1985 • 212 citations

ACUPUNCTURE IN HEROIN ADDICTS: CHANGES IN MET-ENKEPHALIN AND $beta;-ENDORPHIN IN BLOOD AND CEREBROSPINAL FLUID

1979 • 210 citations

A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors

1965 • 207 citations

Long-Term Analgesic Effects of Inescapable Shock and Learned Helplessness

1979 • 197 citations

Central and peripheral endorphins: Basic and clinical aspects

1983 • 185 citations

CROHN'S DISEASE

1975 • 178 citations

Opiate receptors in mice: Genetic differences

1975 • 171 citations

CXBK mice deficient in opiate receptors show poor electroacupuncture analgesia

1978 • 144 citations

Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains.

1977 • 138 citations

Autoradiographic analysis of mu1, mu2, and delta opioid binding in the central nervous system of C57BL/6BY and CXBK (opioid receptor-deficient) mice

1985 • 137 citations

Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: Effects of naloxone on nociception and behaviour

1983 • 128 citations

Social conflict activates opioid analgesic and ingestive behaviors in male mice

1984 • 125 citations

Morphine antagonists and consummatory behaviors

1981 • 121 citations

THE CENTRAL CONTROL OF APPETITE

1983 • 118 citations

Endogenous opioid peptides: review of physiological, pharmacological and clinical aspects

1982 • 115 citations

Pharmacology, drug actions and reactions

1979 • 111 citations

Addiction Liability of Albino Rats: Breeding for Quantitative Differences in Morphine Drinking

1967 • 107 citations

Opioid peptides and alpha-melanocyte-stimulating hormone in genetically obese (ob/ob) mice during development.

1979 • 105 citations

Inheritance of stress-induced analgesia in mice. Selective breeding study

1986 • 97 citations

The Wellcome Foundation Lecture, 1982 Opioid peptides and their receptors

1985 • 96 citations

A genetic analysis of the response to morphine in mice: Analgesia and running

1975 • 94 citations

Clinical studies of the endogenous opioid system.

1982 • 92 citations

Naltrexone, opiate addiction, and endorphins

1982 • 90 citations

Strain differences in opiate receptors in mouse brain

1981 • 88 citations

Defeat, learned submissiveness, and analgesia in mice: effect of genotype

1984 • 86 citations

Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and biochemical correlations.

1979 • 81 citations

Opioid antagonists.

1967 • 81 citations

Social isolation: Effects on pain threshold and stress-induced analgesia

1983 • 80 citations

A genetic analysis of morphine-induced running and analgesia in the mouse

1975 • 77 citations

Extreme sensitivity of diabetic mice to naloxone-induced suppression of food intake

1982 • 76 citations

BEHAVIOURAL EFFECTS OF OPIOID PEPTIDES

1983 • 75 citations

Effect of various behavioral training and testing procedures on brain β-endorphin-like immunoreactivity and the possible role of β-endorphin in behavioral regulation

1984 • 74 citations

Differentiation of neurochemical basis of stress-induced analgesia in mice by selective breeding

1986 • 73 citations

Genotype-dependent sensitivity to morphine: role of different opiate receptor populations

1980 • 73 citations

Morphine ingestion: Genetic control in mice

1977 • 73 citations

Social conflict analgesia: Studies on naloxone antagonism and morphine cross-tolerance in male DBA/2 mice

1985 • 69 citations

Psychobiology of Opioids

1984 • 64 citations

Inbred strains of mice with variable sensitivity to ethanol exhibit differences in the content and processing of β-endorphin

1986 • 62 citations

Selective breeding for high and low levels of opiate-induced analgesia in mice

1983 • 58 citations

Stress-Induced Analgesia in the Mouse: Strain Comparisons

1985 • 57 citations

Increased immunoreactive dynorphin and leu-enkephalin in posterior pituitary of obese mice (/) and super-sensitivity to drugs that act at kappa receptors

1982 • 55 citations

Footshock-induced analgesia: Its opioid nature depends on the strain of rat

1985 • 47 citations

Genetically determined differences in the effects of morphine on mice

1975 • 47 citations

Strain-dependent modulation of memory by stress in mice

1983 • 46 citations

Secretion pattern of endogenous opioids in chronic schizophrenia

1984 • 45 citations

A genetic analysis of stereotypy in the mouse: Dopaminergic plasticity following chronic stress

1985 • 45 citations

Pharmacology: Drug Actions and Reactions.

1978 • 43 citations

Morphine and memory in DBA/2 mice: Effects of stress and of prior experience

1984 • 43 citations

Genetic analysis of susceptibility to morphine addiction in inbred mice.

1971 • 42 citations

Analgesia and motor activity elicited by morphine and enkephalins in two inbred strains of mice

1978 • 41 citations

Social conflict-induced changes in nociception and β-endorphin-like immunoreactivity in pituitary and discrete brain areas of C57BL/6 and DBA/2 mice

1988 • 40 citations

Coupling of a New, Active Morphine Derivative to Sepharose for Affinity Chromatography

1972 • 40 citations

Dose-dependent effects of heroin on memory in two inbred strains of mice

1980 • 39 citations

Differential effects of opiate agonists-antagonists on morphine-induced hyperexcitability and analgesia in mice

1981 • 38 citations

Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: A comparison of long-acting opiate antagonists

1983 • 36 citations

Genotype-dependent behavioral sensitivity to mu vs. kappa opiate agonists. I. Acute and chronic effects on mouse locomotor activity.

1984 • 36 citations

Psychopharmacogenetics of opioids

1983 • 34 citations

Methionine-Enkephalin andβ-Endorphin Levels in Brain, Pancreas, and Adrenals of db/db Mice*

1985 • 34 citations

Strain-dependent effects of naloxone on discrimination learning in mice

1981 • 34 citations

Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors

1981 • 32 citations

The role of endorphins in neuropsychiatry.

1981 • 32 citations

Dose- and strain-dependent effects of dermorphin and [D-Ala-2-D-Leu-5]enkephalin on passive avoidance behavior in mice.

1985 • 32 citations

Morphine-induced running and analgesia in two strains of mice following septal lesions or modification of brain amines

1975 • 30 citations

Sex Differences in the Content of ?-Endorphin and Enkephalin-Like Peptides in the Pituitary of Obese (ob/ob) Mice

1981 • 28 citations

Dose- and strain-dependent effects of dermorphin and [D-Ala–2-D-Leu–5]enkephalin on passive avoidance behavior in mice.

1985 • 27 citations

Behavioural responses to novelty in two inbred mouse strains after intrahippocampal naloxone and morphine

1982 • 27 citations

Genotype-dependent behavioral sensitivity to mu vs. kappa opiate agonists. II. Antinociceptive tolerance and physical dependence.

1984 • 27 citations

Effects of repeated as compared to single aggressive confrontation on nociception and defense behavior in C57BL/6 and DBA/2 mice

1987 • 25 citations

Strain difference in the effects of morphine on the rectal temperature and respiratory rate in male mice

1986 • 25 citations

Ethanol dependence and the pituitary-adrenal axis in mice I. Genotypic differences in hormone levels.

1983 • 25 citations

The kappa opioid receptor, ingestive behaviors and the obese mouse (ob/ob).

1983 • 25 citations

Long-term analgesic reaction in attacked mice.

1987 • 24 citations

Endorphins in schizophrenia.

1981 • 23 citations

Long-term analgesic reaction in attacked mice.

1987 • 22 citations

Genetic Modulations of Stress‐Induced Analgesia in Mice^a

1986 • 20 citations

Morphine preference of alcohol-avoiding and alcohol-preferring C57BL mice

1978 • 20 citations

Oral intake of morphine in selectively bred rats

1977 • 16 citations

Genetic control of opiate-induced locomotor activity in mice.

1978 • 16 citations

PAIN THRESHOLD AND BRAIN ENDORPHIN LEVELS IN GENETICALLY OBESE (ob/ob) AND OPIATE RECEPTOR DEFICIENT (CXBK) MICE

1980 • 15 citations

Genetic differences in opioids binding sites and in antinociceptice activities of morphine and ethylketocyclazocine

1983 • 15 citations

Opiate receptors and endogenous opiates: Panorama of opiate research

1982 • 12 citations

Addiction liability of Tryon rats: Independent transmission of morphine and alcohol consumption

1978 • 12 citations

Morphine withdrawal in mice selectively bred for differential sensitivity to ethanol

1982 • 11 citations

Role of hippocampal Met-enkephalin in the genotype-dependent regulation of exploratory behavior in mice

1986 • 10 citations

Strain differences in the hyperalgesic effect of a novel κ receptor agonist, U-50488H in mice

1984 • 10 citations

Alcohol-morphine interaction: Oral intake in genetically selecteds Maudsley rats

1982 • 10 citations

Effects of bremazocine on locomotor activity in DBA/2 and C57BL/6 mice.

1985 • 9 citations

Stress induced analgesia: its opioid nature depends on the strain of rat but not on the mode of induction

1985 • 9 citations

Genetic Differences in Avoidance Learning Covary with Non‐opioid Stress‐Induced Analgesia

1986 • 8 citations

Locomotor depression by the opioid benzodiazepine tifluadom in mice.

1984 • 8 citations

Genetic analysis of the effects of morphine on plasma cyclic nucleotides and locomotor activity in male mice

1985 • 7 citations

Opiate Receptors

1983 • 7 citations

Stereoselective Enhancement of Nociception by Opioids in Different Strains of Mice

1985 • 6 citations

Opiate receptor binding and behavioral effects of morphine in RHA/Verh and RLA/Verh rats.

1986 • 6 citations

Effects of morphine and chlordiazepoxide on avoidance behaviour in two inbred strains of mice

1981 • 5 citations

Endorphins in inbred mice with variable sensitivity to ethanol: Effect of acute ethanol treatment

1985 • 5 citations

Rat strain differences in the opiate abstinence syndrome

1978 • 4 citations

A genetic analysis of morphine responses in mice

1984 • 3 citations

The Role of Endorphins in Neuropsychiatry: Modern Problems of Pharmacopsychiatry, Vol. 17

1984 • 1 citations

OPIATE RECEPTOR BINDING DIFFERENCES IN INBRED STRAINS OF MICE

1978 • 1 citations