Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2-opioid receptors

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

A genetic map of the mouse suitable for typing intraspecific crosses.

1992 • 1,114 citations

Sex differences in pain

1997 • 1,111 citations

THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)

1944 • 1,032 citations

A comprehensive genetic map of the mouse genome

1996 • 844 citations

CLASSIFICATION OF OPIOID RECEPTORS

1983 • 787 citations

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

Advanced intercross lines, an experimental population for fine genetic mapping.

1995 • 586 citations

A Macintosh program for storage and analysis of experimental genetic mapping data

1993 • 507 citations

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

1996 • 485 citations

Gender differences in the responses to noxious stimuli

1995 • 475 citations

Maternal Inheritance of Alcohol Abuse

1981 • 468 citations

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

1984 • 417 citations

Orphanin FQ is a functional anti-opioid peptide

1996 • 369 citations

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1994 • 333 citations

Naloxone alters pain perception and somatosensory evoked potentials in normal subjects

1977 • 287 citations

Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement

1993 • 263 citations

Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.

1991 • 231 citations

Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor

1994 • 192 citations

Identification of sex–specific quantitative trait loci controlling alcohol preference in C57BL/6 mice

1996 • 188 citations

Heritability of symptoms in an experimental model of neuropathic pain

1990 • 178 citations

A modified hot-plate test sensitivie to mild analgesics

1986 • 176 citations

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

1991 • 171 citations

Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains

1996 • 166 citations

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

1996 • 154 citations

The genetics of pain and pain inhibition.

1996 • 152 citations

Gene Trees and the Origins of Inbred Strains of Mice

1991 • 151 citations

Daily rhythms of analgesia in mice: effects of age and photoperiod

1983 • 146 citations

Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice

1987 • 139 citations

Genetic Relationships Between Inbred Strains of Mice

1972 • 128 citations

An overview of neurobiological comparisons in mouse strains

1980 • 111 citations

Characterization of supraspinal antinociceptive actions of opiod delta agonists in the rat

1995 • 92 citations

Autotomy following nerve injury: Genetic factors in the development of chronic pain

1980 • 91 citations

Action at the mu receptor is sufficient to explain the supraspinal analgesic effect of opiates

1988 • 90 citations

Sex and Genotype Determine the Selective Activation of Neurochemically-Distinct Mechanisms of Swim Stress-Induced Analgesia

1997 • 90 citations

N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. II. Comparison across three swim-stress paradigms in selectively bred mice

1992 • 89 citations

Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone

1992 • 87 citations

7-Benzylidenenaltrexone (BNTX): A selective δ1 opioid receptor antagonist in the mouse spinal cord

1993 • 85 citations

Chromosome Mapping of Gene Loci Affecting Morphine and Amphetamine Responses in BXD Recombinant Inbred Micea

1992 • 79 citations

Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ2-agonist antinociception

1994 • 72 citations

Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice

1995 • 69 citations

Opioids and behavior: genetic aspects

1988 • 68 citations

Sex differences in the expression and antagonism of swim stress-induced analgesia in deer mice vary with the breeding season

1995 • 61 citations

Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.

1991 • 56 citations

Regional expression and chromosomal localization of the delta opiate receptor gene.

1993 • 55 citations

Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse.

1992 • 54 citations

Murine Chromosomal Location of the μ and κ Opioid Receptor Genes

1994 • 53 citations

Enkephalin antinociception in mice is mediated by δ1- and δ2-opioid receptors in the brain and spinal cord, respectively

1993 • 49 citations

One or two genetic loci mediate high opiate analgesia in selectively bred mice

1995 • 48 citations

Studies of Genetic Differences in Response to Opioid Drugs

1991 • 48 citations

Naloxone does not alter the perception of pain induced by electrical and thermal stimulation of the skin in healthy humans

1988 • 44 citations

Chromosomal localization of opioid peptide and receptor genes in the mouse

1995 • 43 citations

Involvement of spinal κ opioid receptors in a type of footshock induced analgesia in mice

1993 • 42 citations

δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites

1992 • 41 citations

The involvement of opioid δ-receptors in stress induced antinociception in mice

1983 • 36 citations

Differences in morphine reinforcement property in two inbred rat strains: associations with cortical receptors, behavioral activity, analgesia and the cataleptic effects of morphine

1993 • 35 citations

Inbred strain differences in morphine-induced analgesia with the hot plate assay: A reassessment

1990 • 35 citations

Genetic predisposition to hypertension, elevated blood pressure and pain sensitivity: a functional analysis

1984 • 33 citations

Spontaneously (genetic) hypertensive rats: Naloxone-reversible and propranolol-reversible decrease in pain sensitivity

1981 • 32 citations

The selective κ-opioid agonist, U-50,488H, produces antinociception in the rat via a supraspinal action

1987 • 23 citations

Difference in the development of tolerance to morphine and d-ala2-methionine-enkephalin in C57 BL/6J and DBA/2J mice

1981 • 18 citations

Genotype and test experience determine responsiveness to morphine

1978 • 17 citations

The sensitivity to noxious heat in relation to brain and liver opioid glucuronidation in inbred strains of mice

1989 • 13 citations

Differential mediation of cold water swim stress-induced antinociception by δ-opioid receptor subtypes in diabetic mice

1994 • 9 citations

The serotonin 5-HT1B receptor subtype (Htr1b) gene maps to mouse Chromosome 9

1993 • 7 citations

[The genetic characteristics of the brain alpha 2-adrenergic and S2-serotoninergic systems in the realization of the tail-jerk pain reflex and its morphine suppression in rats].

1995 • 3 citations

GENOMIC ANALYSIS OF THE HUMAN KAPPA OPIOID RECEPTOR: NO EVIDENCE FOR MULTIPLE GENES

1995 • 1 citations