Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

2000 • 1,096 citations

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

2001 • 1,017 citations

Activation of the JAK-STAT pathway by reactive oxygen species

1998 • 566 citations

Role of Reactive Oxygen Species in TGF-β1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells

2005 • 506 citations

Reactive Oxygen Species-Regulated Signaling Pathways in Diabetic Nephropathy

2003 • 463 citations

Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB

2002 • 372 citations

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

1992 • 353 citations

Role of Advanced Glycation End Products in Diabetic Nephropathy

2003 • 344 citations

Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose

2000 • 312 citations

ROS Generation by Nonphagocytic NADPH Oxidase

2003 • 288 citations

Angiotensin II induces superoxide anion production by mesangial cells

1998 • 274 citations

Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells

2003 • 272 citations

Role of High Glucose-Induced Nuclear Factor-κB Activation in Monocyte Chemoattractant Protein-1 Expression by Mesangial Cells

2002 • 269 citations

High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells.

1990 • 228 citations

Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells

2001 • 215 citations

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

2003 • 205 citations

Role of angiotensin II in glucose-induced inhibition of mesangial matrix degradation.

1999 • 200 citations

AGEs induce oxidative stress and activate protein kinase C-β_IIin neonatal mesangial cells

2000 • 199 citations

Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes

2000 • 189 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Inhibition of the JAK/STAT Signaling Pathway Prevents the High Glucose-Induced Increase in TGF-β and Fibronectin Synthesis in Mesangial Cells

2002 • 165 citations

AP-1 Proteins Mediate Hyperglycemia-Induced Activation of the Human TGF-β1 Promoter in Mesangial Cells

2000 • 162 citations

Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells

2003 • 146 citations

Melatonin and taurine reduce early glomerulopathy in diabetic rats

1999 • 135 citations

Antioxidant inhibition of protein kinase C—signaled increases in transforming growth factor-beta in mesangial cells

1997 • 134 citations

Sequential effects of high glucose on mesangial cell transforming growth factor-β1 and fibronectin synthesis

1998 • 133 citations

Role of oxidative stress in advanced glycation end product-induced mesangial cell activation

2002 • 131 citations

Reactive oxygen species mediate high glucose–induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney

2005 • 127 citations

Effect of High Glucose on Type IV Collagen Production by Cultured Glomerular Epithelial, Endothelial, and Mesangial Cells

1993 • 120 citations

Taurine Prevents Glucose-Induced Lipid Peroxidation and Increased Collagen Production in Cultured Rat Mesangial Cells

1993 • 109 citations

Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway

2001 • 108 citations

Reactive oxygen species mediate TGF-β1-induced plasminogen activator inhibitor-1 upregulation in mesangial cells

2003 • 105 citations

Angiotensin II-Induced Mesangial Cell Apoptosis: Role of Oxidative Stress

2002 • 90 citations

Angiotensin II Mediates High Glucose-Induced TGF-β1 and Fibronectin Upregulation in HPMC through Reactive Oxygen Species

2005 • 89 citations

The Hexosamine Pathway Regulates the Plasminogen Activator Inhibitor-1 Gene Promoter and Sp1 Transcriptional Activation through Protein Kinase C-βI and -δ

2002 • 89 citations

Small heat shock protein alteration provides a mechanism to reduce mesangial cell contractility in diabetes and oxidative stress

2000 • 77 citations

Activation of protein kinase C-δ and C-ϵ by oxidative stress in early diabetic rat kidney

2001 • 61 citations

Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium

1993 • 56 citations

Vitamin E Prevents Glucose-Induced Lipid Peroxidation and Increased Collagen Production in Cultured Rat Mesangial Cells

1994 • 55 citations

Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells.

1997 • 50 citations

ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species

2004 • 40 citations

High Glucose Reduces Generation of Plasmin Activity by Mesangial Cells

1997 • 26 citations

Effects of silibinin and antioxidants on high glucose-induced alterations of fibronectin turnover in human mesangial cell cultures.

1996 • 21 citations

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