Kinetic Evolution of a Diabetogenic CD8+ T Cell Response

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Structural Insights into the Evolution of an Antibody Combining Site

1997 • 550 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8⁺T cells in autoimmune diabetes

2003 • 378 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

1997 • 359 citations

Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

2003 • 355 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

1993 • 347 citations

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

2000 • 344 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

1994 • 301 citations

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

2000 • 292 citations

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

1992 • 243 citations

β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes

1994 • 241 citations

Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

1997 • 232 citations

The role of CD8⁺ T cells in the initiation of insulin‐dependent diabetes mellitus

1996 • 225 citations

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile.

1994 • 211 citations

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

1993 • 201 citations

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

1998 • 179 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

Prevalent CD8⁺T cell response against one peptide/MHC complex in autoimmune diabetes

1999 • 153 citations

Identification of a CD8 T Cell That Can Independently Mediate Autoimmune Diabetes Development in the Complete Absence of CD4 T Cell Helper Functions

2000 • 148 citations

Analysis of the roles of CD4⁺ and CD8⁺ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice

1992 • 145 citations

Genetic and pathogenic basis of autoimmune diabetes in NOD mice

1994 • 136 citations

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

1997 • 134 citations

T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.

1991 • 130 citations

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains.

1996 • 130 citations

Perforin-independent β-cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice

1999 • 118 citations

Transfer of Diabetes in the NOD-scid Mouse by CD4 T-Cell Clones: Differential Requirement for CD8 T-Cells

1996 • 115 citations

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.

1991 • 108 citations

In Situ β Cell Death Promotes Priming of Diabetogenic CD8 T Lymphocytes

2002 • 103 citations

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population

1994 • 101 citations

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

1995 • 93 citations

Characterization of T Lymphocytes Infiltrating Human Pancreas Allograft Affected by Isletitis and Recurrent Diabetes

1992 • 93 citations

RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice.

1996 • 88 citations

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus

1995 • 84 citations

Presentation of beta-cell antigens to CD4+ and CD8+ T cells of non-obese diabetic mice.

1993 • 75 citations

Analysis of Families at Risk for Insulin-Dependent Diabetes Mellitus Reveals that HLA Antigens Influence Progression to Clinical Disease

1995 • 75 citations

Collaboration of helper and cytotoxic T lymphocytes

1993 • 72 citations

Expansion of the Antigenic Repertoire of a Single T Cell Receptor upon T Cell Activation

2001 • 70 citations

CD8 T Cells Are Not Required for Islet Destruction Induced by a CD4+ Islet-Specific T-Cell Clone

1992 • 69 citations

The Effect of HLA-B Allele on the IDDM Risk Defined by DRB1*04 Subtypes and DQB1*0302

1997 • 67 citations

Studies on Autoimmunity for T-Cell-Mediated β-Cell Destruction: Distinct Difference in β-Cell Destruction Between CD4+ and CD8+ T-Cell Clones Derived From Lymphocytes Infiltrating the Islets of NOD Mice

1992 • 60 citations

Exclusive Expression of MHC Class II Proteins on CD45+ Cells in Pancreatic Islets of NOD Mice

1991 • 56 citations

Major Histocompatibility Complex Class I–Restricted Infiltration and Destruction of Pancreatic Islets by NOD Mouse-Derived β-Cell Cytotoxic CD8+ T-Cell Clones In Vivo

1996 • 54 citations

CD154-Dependent Priming of Diabetogenic CD4+ T Cells Dissociated from Activation of Antigen-Presenting Cells

2002 • 43 citations

Human Leukocyte Antigen-A24 and -DQA1*0301 in Japanese Insulin-Dependent Diabetes Mellitus: Independent Contributions to Susceptibility to the Disease and Additive Contributions to Acceleration of β-Cell Destruction*

1999 • 41 citations

Morphological Analysis of Selective Destruction of Pancreatic β-cells by Cytotoxic T Lymphocytes in NOD Mice

1991 • 35 citations

CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone

1992 • 32 citations

Studies on autoimmunity for T-cell-mediated beta-cell destruction. Distinct difference in beta-cell destruction between CD4+ and CD8+ T-cell clones derived from lymphocytes infiltrating the islets of NOD mice

1992 • 27 citations

Human Leukocyte Antigen-A24 and -DQA10301 in Japanese Insulin-Dependent Diabetes Mellitus: Independent Contributions to Susceptibility to the Disease and Additive Contributions to Acceleration of -Cell Destruction

1999 • 16 citations

Morphological analysis of selective destruction of pancreatic beta-cells by cytotoxic T lymphocytes in NOD mice

1991 • 12 citations