Regulation of Oct-4 gene expression during differentiation of EC cells

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 924 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Teratocarcinomas and Mammalian Embryogenesis

1980 • 767 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1990 • 745 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor.

1989 • 664 citations

Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation

1994 • 623 citations

Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.

1990 • 603 citations

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

1992 • 577 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

COUP transcription factor is a member of the steroid receptor superfamily

1989 • 480 citations

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

1994 • 470 citations

POU-domain transcription factors: pou-er-ful developmental regulators.

1991 • 461 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

1992 • 388 citations

Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

1991 • 382 citations

Octamania: The POU factors in murine development

1991 • 373 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

POU domain transcription factors

1993 • 278 citations

The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells.

1992 • 237 citations

COUP Orphan Receptors Are Negative Regulators of Retinoic Acid Response Pathways

1992 • 216 citations

Evidence that Hensen's node is a site of retinoic acid synthesis

1992 • 216 citations

Identification of two novel members oferbAsuperfamily by molecular cloning: the gene products of the two are highly related to each other

1988 • 212 citations

Induced muscle differentiation in an embryonal carcinoma cell line.

1983 • 181 citations

The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.

1991 • 181 citations

Repression of the IgH Enhancer in Teratocarcinoma Cells Associated with a Novel Octamer Factor

1989 • 176 citations

An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development.

1993 • 157 citations

Mechanisms of transactivation by retinoic acid receptors

1993 • 156 citations

Gene expression during preimplantation mouse development.

1992 • 152 citations

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors

1994 • 143 citations

COUP orphan receptors are negative regulators of retinoic acid response pathways.

1992 • 141 citations

Orphan receptors: in search of a unifying hypothesis for activation.

1992 • 138 citations

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

1990 • 134 citations

Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations.

1990 • 126 citations

A New Orphan Member of the Nuclear Hormone Receptor Superfamily That Interacts with a Subset of Retinoic Acid Response Elements

1994 • 125 citations

Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo.

1992 • 122 citations

Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region.

1994 • 113 citations

The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis.

1990 • 113 citations

Characterization of a negative retinoic acid response element in the murine Oct4 promoter.

1994 • 107 citations

Clonal variants of differentiated P19 embryonal carcinoma cells exhibit epidermal growth factor receptor kinase activity

1985 • 107 citations

Antagonism between Retinoic Acid Receptors

1991 • 91 citations

Regulation of theOct-4gene by nuclear receptors

1994 • 89 citations

Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Dimers Bind to Different GGTCA Response Elements, Allowing COUP-TF To Repress Hormonal Induction of the Vitamin D₃, Thyroid Hormone, and Retinoic Acid Receptors

1992 • 84 citations

Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region.

1993 • 77 citations

Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential.

1993 • 74 citations

An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells.

1993 • 65 citations

Aggregation and cell cycle dependent retinoic acid receptor mRNA expression in P19 embryonal carcinoma cells

1992 • 62 citations

Antagonism between retinoic acid receptors.

1991 • 55 citations

Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells

1991 • 50 citations

Induction of a RARβ2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system

1992 • 44 citations

Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells.

1993 • 44 citations

Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RARα

1992 • 43 citations

Induced Muscle Differentiation in an Embryonal Carcinoma Cell Line

1983 • 41 citations

Characterization of a Negative Retinoic Acid Response Element in the Murine Oct4 Promoter

1994 • 37 citations

Retinoic Acid Represses Oct-3/4 Gene Expression through Several Retinoic Acid-Responsive Elements Located in the Promoter-Enhancer Region

1994 • 34 citations

A Dominant Negative Mutation of the Alpha Retinoic Acid Receptor Gene in a Retinoic Acid-Nonresponsive Embryonal Carcinoma Cell

1990 • 31 citations

Inhibition of differentiation by leukemia inhibitory factor distinguishes two induction pathways in P19 embryonal carcinoma cells

1992 • 25 citations

Expression of Pax-3- and neuroectoderm-inducing activities during differentiation of P19 embryonal carcinoma cells

1992 • 24 citations

Isolation of high affinity cellular targets of the embryonal LTR binding protein, an undifferentiated embryonal carcinoma cell-specific repressor of Moloney leukemia virus

1992 • 22 citations

Dominant negative retinoic acid receptor β

1993 • 22 citations

An Octamer Motif Contributes to the Expression of the Retinoic Acid-Regulated Zinc Finger Gene Rex-1 (Zfp-42) in F9 Teratocarcinoma Cells

1993 • 20 citations

Extinction of Oct-3/4 Gene Expression in Embryonal Carcinoma × Fibroblast Somatic Cell Hybrids is Accompanied by Changes in the Methylation Status, Chromatin Structure, and Transcriptional Activity of the Oct-3/4 Upstream Region

1993 • 19 citations

Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities

1994 • 16 citations

Changes in Hox1.6, c-jun, and Oct-3 Gene Expressions Are Associated with Teratocarcinoma F9 Cell Differentiation in Three Different Ways of Induction

1993 • 13 citations

The murineHox-2.4promoter contains a functional octamer motif

1992 • 11 citations

Convergent Regulation of NF-IL6 and Oct-1 Synthesis by Interleukin-6 and Retinoic Acid Signaling in Embryonal Carcinoma Cells

1993 • 10 citations