Regulatory Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

1992 • 1,258 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

[1] Assays of protein kinase

1983 • 832 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Modulation of Calmodulin Plasticity in Molecular Recognition on the Basis of X-Ray Structures

1993 • 615 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.

1994 • 370 citations

Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I

1996 • 329 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

Components of a Calmodulin-dependent Protein Kinase Cascade

1998 • 249 citations

A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase.

1999 • 239 citations

Characterization of a Ca2+/Calmodulin-dependent Protein Kinase Cascade

1995 • 221 citations

Regulatory and structural motifs of chicken gizzard myosin light chain kinase.

1990 • 208 citations

Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.

1995 • 182 citations

Functional Analysis of a Complementary DNA for the 50-Kilodalton Subunit of Calmodulin Kinase II

1987 • 179 citations

Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity.

1990 • 167 citations

Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.

1994 • 150 citations

An Expression System of Rat Calmodulin Using T7 Phage Promoter inEscherichia coli

1998 • 141 citations

Phosphorylation and Activation of Ca2+-Calmodulin-dependent Protein Kinase IV by Ca2+-Calmodulin-dependent Protein Kinase Ia Kinase

1995 • 137 citations

Multifunctional calcium/calmodulin-dependent protein kinase made calcium-independent for functional studies

1990 • 127 citations

Requirements for Calcium and Calmodulin in the Calmodulin Kinase Activation Cascade

1996 • 122 citations

Activation of Ca2+/Calmodulin-dependent Protein Kinase (CaM-kinase) IV by CaM-kinase Kinase in Jurkat T Lymphocytes

1995 • 111 citations

Multiple Ca2+-Calmodulin-dependent Protein Kinase Kinases from Rat Brain

1996 • 96 citations

Inhibition of the Ca2+/Calmodulin-dependent Protein Kinase I Cascade by cAMP-dependent Protein Kinase

1999 • 82 citations

Molecular Cloning of Ca2+/Calmodulin-Dependent Protein Kinase Kinase

1997 • 81 citations

A protein activator of Ca(2+)-calmodulin-dependent protein kinase Ia.

1994 • 80 citations

Characterization of the Mechanism of Regulation of Ca2+/ Calmodulin-dependent Protein Kinase I by Calmodulin and by Ca2+/Calmodulin-dependent Protein Kinase Kinase

1998 • 78 citations

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

1992 • 77 citations

Mutational analysis of the autoinhibitory domain of calmodulin kinase II.

1994 • 69 citations

Calcium/Calmodulin-Dependent Protein Kinase Kinase: Identification of Regulatory Domains

1997 • 67 citations

Purification and Characterization of Ca2+/Calmodulin-Dependent Protein Kinase IV Kinase from Rat Brain1

1994 • 57 citations

Substrate Recognition by Ca2+/Calmodulin-dependent Protein Kinase Kinase

1999 • 57 citations

Domain characterization of rabbit skeletal muscle myosin light chain kinase.

1990 • 52 citations

Ca2+/Calmodulin-dependent Protein Kinase Cascade in Caenorhabditis elegans

1999 • 49 citations

Activation of a Calcium-Calmodulin-dependent Protein Kinase I Cascade in PC12 Cells

1996 • 40 citations

Biochemical properties of chimeric skeletal and smooth muscle myosin light chain kinases.

1992 • 38 citations

Basic residues are important for Ca2+/calmodulin binding and activation but not autoinhibition of rabbit skeletal muscle myosin light chain kinase

1991 • 36 citations

Mutational Analysis of Ca2+-independent Autophosphorylation of Calcium/Calmodulin-dependent Protein Kinase II

1995 • 22 citations