Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes

The language of covalent histone modifications

2000 • 8,260 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Histone acetylation and an epigenetic code

2000 • 1,164 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Stabilization of Chromatin Structure by PRC1, a Polycomb Complex

1999 • 794 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

2000 • 716 citations

Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter

1999 • 703 citations

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

1999 • 518 citations

Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.

1988 • 460 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

Imprinting a determined state into the chromatin of Drosophila

1990 • 391 citations

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins

2001 • 384 citations

Reconstitution of a Functional Core Polycomb Repressive Complex

2001 • 367 citations

Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes

2001 • 359 citations

Mechanisms of transcriptional memory

2001 • 354 citations

Polycombing the Genome: PcG, trxG, and Chromatin Silencing

1998 • 352 citations

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.

1994 • 346 citations

TAFs revisited: more data reveal new twists and confirm old ideas

2000 • 322 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function.

1993 • 319 citations

Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products

1993 • 317 citations

Re-SET-ting heterochromatin by histone methyltransferases

2001 • 306 citations

The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes

1998 • 287 citations

Locking in stable states of gene expression: transcriptional control during Drosophila development

1995 • 283 citations

Cell cycle-regulated histone acetylation required for expression of the yeast HO gene

1999 • 275 citations

The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3

2001 • 269 citations

Chromatid Segregation at Anaphase Requires the barren Product, a Novel Chromosome-Associated Protein That Interacts with Topoisomerase II

1996 • 267 citations

Histone Acetylation and Chromatin Remodeling

2001 • 264 citations

Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans

1998 • 253 citations

Physical and functional association of SU(VAR)3‐9 and HDAC1 in Drosophila

2001 • 253 citations

General transcription factors bind promoters repressed by Polycomb group proteins

2001 • 240 citations

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

1999 • 239 citations

Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.

1992 • 231 citations

Polycomb group proteins and heritable silencing of Drosophila Hox genes

2001 • 230 citations

Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

1998 • 219 citations

Structure of a Polycomb Response Element and In Vitro Binding of Polycomb Group Complexes Containing GAGA Factor

2000 • 213 citations

SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates?

1999 • 212 citations

Trithorax and dCBP Acting in a Complex to Maintain Expression of a Homeotic Gene

2001 • 202 citations

The Distribution of Polycomb-Group Proteins During Cell Division and Development in Drosophila Embryos: Impact on Models for Silencing

1998 • 195 citations

A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human Retinoblastoma Binding Protein 2

2000 • 192 citations

ATP-Driven Chromatin Remodeling Activity and Histone Acetyltransferases Act Sequentially during Transactivation by RAR/RXR In Vitro

2000 • 184 citations

The DNA-binding polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene

1999 • 181 citations

Binding of Trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis

1998 • 179 citations

The iab-7 Polycomb Response Element Maps to a Nucleosome-Free Region of Chromatin and Requires Both GAGA and Pleiohomeotic for Silencing Activity

2001 • 178 citations

Establishment of Polycomb silencing requires a transient interaction between PC and ESC

2001 • 174 citations

The Drosophila Brahma complex is an essential coactivator for the trithorax group protein Zeste

2000 • 169 citations

Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic

1997 • 159 citations

The MCP silencer of theDrosophila Abd-Bgene requires both Pleiohomeotic and GAGA factor for the maintenance of repression

2001 • 152 citations

The Polycomb group — no longer an exclusive club?

2001 • 150 citations

A Drosophila ESC-E(Z) Protein Complex Is Distinct from Other Polycomb Group Complexes and Contains Covalently Modified ESC

2000 • 150 citations

Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes

1999 • 150 citations

Interaction of the Arabidopsis Polycomb group proteins FIE and MEA mediates their common phenotypes

2000 • 149 citations

MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein

1998 • 148 citations

Transcriptional silencing by the Polycomb protein in Drosophila embryos.

1995 • 143 citations

Osa-containing Brahma chromatin remodeling complexes are required for the repression of Wingless target genes

2000 • 141 citations

A Domain Shared by the Polycomb Group Proteins Scm and ph Mediates Heterotypic and Homotypic Interactions

1997 • 139 citations

The Polycomb group in Caenorhabditis elegans and maternal control of germline development

1998 • 138 citations

The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity

1999 • 126 citations

Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes

1998 • 123 citations

RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity

1999 • 122 citations

The trithorax Group Gene moira Encodes a Brahma-Associated Putative Chromatin-Remodeling Factor in Drosophila melanogaster

1999 • 121 citations

The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the Brahma chromatin-remodeling factor to regulate transcription

1999 • 117 citations

Drosophila Chromosome Condensation Proteins Topoisomerase II and Barren Colocalize with Polycomb and Maintain Fab-7 PRE Silencing

2001 • 112 citations

The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes

2001 • 111 citations

Polycomblike PHD Fingers Mediate Conserved Interaction with Enhancer of Zeste Protein

2001 • 108 citations

Trithorax- and Polycomb-Group Response Elements within an Ultrabithorax Transcription Maintenance Unit Consist of Closely Situated but Separable Sequences

1999 • 106 citations

Recruitment of components of Polycomb Group chromatin complexes in Drosophila

2001 • 101 citations

Site-Specific Recognition of a 70-Base-Pair Element Containing d(GA)_n Repeats Mediatesbithoraxoid Polycomb Group Response Element-Dependent Silencing

2001 • 96 citations

Functional Analysis of Repressor Binding Sites in the iab-2 Regulatory Region of the abdominal-A Homeotic Gene

2000 • 91 citations

A Genetic Screen for Modifiers of a Kinase Suppressor of Ras-Dependent Rough Eye Phenotype in Drosophila

2000 • 88 citations

Functional Interaction between the Coactivator Drosophila CREB-Binding Protein and ASH1, a Member of the Trithorax Group of Chromatin Modifiers

2000 • 76 citations

Trithorax and ASH1 Interact Directly and Associate with the Trithorax Group-Responsive bxd Region of the Ultrabithorax Promoter

1999 • 75 citations

Polycomb Group Repression Reduces DNA Accessibility

2001 • 70 citations

A homeotic mutation in the trithorax SET domain impedes histone binding

2001 • 68 citations

The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos

2001 • 65 citations

The HMG-domain protein BAP111 is important for the function of the BRM chromatin-remodeling complex in vivo

2001 • 59 citations

Essential role of Drosophila Hdac1 in homeotic gene silencing

2001 • 58 citations

The Drosophila Polycomb Protein Interacts with Nucleosomal Core Particles In Vitro via Its Repression Domain

1999 • 47 citations

A Genetic Screen of the Drosophila X Chromosome for Mutations That Modify Deformed Function

1998 • 43 citations

The Trithorax-mimic Allele of Enhancer of zeste Renders Active Domains of Target Genes Accessible to Polycomb-Group-Dependent Silencing in Drosophila melanogaster

2001 • 30 citations

Long-Range Repression by Multiple Polycomb Group (PcG) Proteins Targeted by Fusion to a Defined DNA-Binding Domain in Drosophila

2001 • 26 citations