The role of cytosolic free calcium in the regulation of pyruvate dehydrogenase in synaptosomes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

The role of calcium in cell death

1981 • 637 citations

Calcium and Ischemic Injury

1986 • 529 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Historical Overview

1988 • 428 citations

A rapid method for isolation of synaptosomes on Percoll gradients

1986 • 421 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1980 • 375 citations

A Ca2+-insensitive form of fura-2 associated with polymorphonuclear leukocytes. Assessment and accurate Ca2+ measurement.

1987 • 317 citations

Function of calcium ions in pyruvate dehydrogenase phosphatase activity

1972 • 157 citations

Regulation of Mammalian Pyruvate Dehydrogenase Complex by a Phosphorylation–Dephosphorylation Cycle

1981 • 153 citations

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

1985 • 139 citations

Dehydrogenase activation by Ca2+ in cells and tissues

1991 • 131 citations

Current topics in cellular regulation. Vol. 23

1985 • 125 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential

1980 • 100 citations

The role of mitochondrial Ca2+ transport and matrix Ca2+ in signal transduction in mammalian tissues

1990 • 99 citations

Effects of antibiotic lonophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria

1973 • 96 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes

1987 • 83 citations

Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

1986 • 74 citations

Phosphorylation‐Mediated Changes in Pyruvate Dehydrogenase Activity Influence Pyruvate‐Supported Calcium Accumulation by Brain Mitochondria

1981 • 68 citations

Evidence that the 40,000 Mr phosphoprotein influenced by high frequency synaptic stimulation is the alpha subunit of pyruvate dehydrogenase

1981 • 65 citations

Pyruvate Dehydrogenase Activity in the Rat Cerebral Cortex following Cerebral Ischemia

1989 • 62 citations

Effect of Dichloroacetate on Regional Energy Metabolites and Pyruvate Dehydrogenase Activity During Ischemia and Reperfusion in Gerbil Brain

1989 • 56 citations

Cytosolic-free calcium and neurotransmitter release with decreased availability of glucose or oxygen

1989 • 52 citations

Pyruvate dehydrogenase complex is inhibited in calcium-loaded cerebrocortical mitochondria

1988 • 47 citations

Effect of inotropic stimulation on mitochondrial calcium in cardiac muscle.

1992 • 45 citations

The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomes

1980 • 44 citations

Synaptosomal Calcium Metabolism During Hypoxia and 3,4‐Diaminopyridine Treatment

1984 • 42 citations

Effects of Ca2+ on the Activities of the Calcium-Sensitive Dehydrogenases Within the Mitochondria of Mammalian Tissues

1988 • 36 citations

Pyruvate Dehydrogenase Phosphate (PDH_b) Phosphatase in Brain: Activity, Properties, and Subcellular Localization

1983 • 32 citations

Acetylcholine Synthesis and CO₂ Production from Variously Labeled Glucose in Rat Brain Slices and Synaptosomes

1981 • 29 citations

Pyruvate utilization by synaptosomes is independent of calcium

1986 • 26 citations

Subsynaptosomal Calcium Distribution During Hypoxia and 3,4‐Diaminopyridine Treatment

1985 • 26 citations

Relationship Between Activation State of Pyruvate Dehydrogenase Complex and Rate of Pyruvate Oxidation in Isolated Cerebro‐Cortical Mitochondria: Effects of Potassium Ions and Adenine Nucleotides

1985 • 25 citations

Regulation of the pyruvate dehydrogenase complex by Ca2+ within toluene-permeabilized heart mitochondria

1989 • 22 citations

Interrelationships (Between Glucose Metabolism, Energy State, and the Cytosolic Free Calcium Concentration in Cortical Synjaptosomes from the Guinea Pig

1989 • 21 citations

Cytosolic free calcium concentrations in synaptosomes during histotoxic hypoxia

1991 • 21 citations

Cytosolic free calcium and ATP in synaptosomes after ischemia

1991 • 16 citations

PYRUVATE DEHYDROGENASE ACTIVATION IN RAT BRAIN CORTICAL SLICES BY ELEVATED CONCENTRATIONS OF EXTERNAL POTASSIUM IONS

1977 • 15 citations

Pyruvate dehydrogenase dephosphorylation in rat brain synaptosomes and mitochondria: Evidence for a calcium-mediated effect in response to depolarization, and variations due to ageing

1992 • 14 citations

Activation of Pyruvate Dehydrogenase Complex by Ca²⁺in Intact Heart, Cardiac Myocytes, and Cardiac Mitochondria

1989 • 14 citations

Changes in Pyruvate Dehydrogenase Complex Activity during and following Severe Insulin-Induced Hypoglycemia

1991 • 12 citations

Relationship Between Cytosolic Free Calcium Ion Concentration and the Control of Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Synaptosomes

1988 • 4 citations

Regulation of Respiration and Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Hepatocytes

1988 • 2 citations