Role of Langerhans cells and other dendritic cells in viral diseases

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 ⁺ T Cells

1992 • 624 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.

1991 • 437 citations

Epidermal Langerhans Cells-A Target for HTLV-III/LAV Infection

1987 • 414 citations

Disseminated Vaccinia in a Military Recruit with Human Immunodeficiency Virus (HIV) Disease

1987 • 412 citations

The Cell Biology of Antigen Processing and Presentation

1991 • 349 citations

Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

1992 • 327 citations

An Inquiry into the Mechanisms of Herpes Simplex Virus Latency

1987 • 323 citations

Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus

1987 • 314 citations

Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6

1989 • 308 citations

The role of langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs

1976 • 304 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Reduced Langerhans’ Cell Ia Antigen and ATPase Activity in Patients with the Acquired Immunodeficiency Syndrome

1984 • 279 citations

Dendritic cell infection, depletion and dysfunction in HIV-infected individuals.

1990 • 278 citations

Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing.

1992 • 265 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

Expression of the HTLV-III envelope gene by a recombinant vaccinia virus

1986 • 240 citations

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.

1990 • 238 citations

Langerhans Cell Production of Interleukin-1

1984 • 233 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

Tumor antigen presentation by murine epidermal cells.

1991 • 211 citations

Susceptibility of Human Peripheral Blood Dendritic Cells to Infection by Human Immunodeficiency Virus

1987 • 200 citations

S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis

1989 • 176 citations

Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures.

1991 • 165 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

AN ALTERNATIVE THEORY OF HERPES-SIMPLEX RECURRENCE AND A POSSIBLE ROLE FOR PROSTAGLANDINS

1976 • 145 citations

Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus

1992 • 140 citations

Langerhans cells and prognosis in patients with gastric carcinoma

1987 • 133 citations

Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes

1992 • 132 citations

During HIV-1 infection most blood dendritic cells are not productively infected and can induce allogeneic CD4+ T cells clonal expansion

1992 • 131 citations

Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas.

1992 • 130 citations

Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes.

1992 • 128 citations

Dendritic/Langerhans Cells and Prognosis in Patients with Papillary Thyroid Carcinomas: Immunocytochemical Study of 106 Thyroid Neoplasms Correlated to Follow-up Data

1988 • 125 citations

Langerhans' cells are an actual site of HIV-1 replication.

1988 • 118 citations

Suppression of immune responses by dendritic cells infected with HIV.

1989 • 115 citations

The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8- T cells and is restricted to the DR region of the MHC complex.

1988 • 110 citations

Absence of Langerhans Cells in Oral Hairy Leukoplakia, an AIDS-Associated Lesion

1987 • 108 citations

Functional Dichotomy between Langerhans Cells that Present Antigen to Naive and to Memory/Effector T Lymphocytes

1990 • 104 citations

Langerhans’cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia

1983 • 103 citations

Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity

1989 • 101 citations

Activated Langerhans Cells Release Tumor Necrosis Factor

1989 • 97 citations

Primary proliferative and cytotoxic T-cell responses to HIV induced in vitro by human dendritic cells.

1991 • 92 citations

Effect of Aging on Epidermal Dendritic Cell Populations in C57BL/6J Mice

1990 • 91 citations

Langerhans Cells Related to Prognosis in Patients With Laryngeal Carcinoma

1991 • 90 citations

MHC class II expression by Langerhans' cells and lymph node dendritic cells: possible evidence for maturation of Langerhans' cells following contact sensitization.

1991 • 84 citations

Antigen-presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection.

1992 • 83 citations

Detection of HIV-1 in Epidermal Langerhans Cells of HIV-Infected Patients Using the Polymerase Chain Reaction

1990 • 81 citations

Ultraviolet B-Irradiated Antigen-Presenting Cells Display Altered Accessory Signaling for T-Cell Activation: Relevance to Immune Responses Initiated in Skin

1992 • 80 citations

Cardiac myocytes and dendritic cells harbor human immunodeficiency virus in infected patients with and without cardiac dysfunction: Detection by multiplex, nested, polymerase chain reaction in individually microdissected cells from right ventricular endomyocardial biopsy tissue

1991 • 76 citations

Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells

1991 • 76 citations

Quantitative assessment of Langerhans' cells in human cervical intraepithelial neoplasia and wart virus infection

1986 • 76 citations

Microglial cells in human brain have phenotypic characteristics related to possible function as dendritic antigen presenting cells

1989 • 76 citations

Studies on human epidermal Langerhans' cells: II. Activation of human T lymphocytes to herpes simplex virus

1980 • 75 citations

Role of T-lymphocyte subsets in recovery from herpes simplex virus infection

1984 • 73 citations

Morphology and phenotype of dendritic cells from peripheral blood and their productive and non-productive infection with human immunodeficiency virus type 1.

1991 • 73 citations

Failure or success in the restoration of virus-specific cytotoxic T lymphocyte response defects by dendritic cells.

1988 • 67 citations

Langerhans cells in HIV-1 infection

1990 • 67 citations

The Human Immunodeficiency Virus Long Terminal Repeat Is Preferentially Expressed in Langerhans Cells in Transgenic Mice

1989 • 64 citations

Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease.

1991 • 62 citations

Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipoxygenase pathways.

1987 • 61 citations

Biology of Langerhans Cells: Analysis by Experiments to Deplete Langerhans Cells from Human Skin

1984 • 60 citations

HLA-DR antigen- and S-100 protein-positive dendritic cells in esophageal squamous cell carcinoma— Their distribution in relation to prognosis

1992 • 60 citations

Isolation of Herpes Simplex Virus from the Skin of Clinically Normal Mice During Latent Infection

1980 • 60 citations

Tumor antigen presentation by epidermal antigen-presenting cells in the mouse: modulation by granulocyte-macrophage colony-stimulating factor, tumor necrosis factor α, and ultraviolet radiation

1992 • 59 citations

Langerhans Cells and Epithelial Cell Modifications in Cervical Intraepithelial Neoplasia: Correlation with Human Papillomavirus Infection

1990 • 59 citations

Immunohistochemical Study of Normal Skin of HIV-1—Infected Patients Shows No Evidence of Infection of Epidermal Langerhans Cells by HIV

1989 • 59 citations

Herpes simplex virus type 1 pathogenicity in footpad and ear skin of mice depends on Langerhans cell density, mouse genetics, and virus strain

1987 • 58 citations

Skin Langerhans cells play an essential role in the defense against HSV-1 infection

1986 • 57 citations

Langerhans cell density and activity in mouse skin and lymph nodes affect herpes simplex type 1 (HSV-1) pathogenicity

1989 • 55 citations

Modulation of the population density of identifiable epidermal Langerhans cells associated with enhancement or suppression of cutaneous immune reactivity.

1986 • 53 citations

Langerhans' cells and subtypes of human papillomavirus in cervical intraepithelial neoplasia.

1988 • 53 citations

Detection of IL-1?, TNF-?, and IL-6 gene transcription by the polymerase chain reaction in keratinocytes, Langerhans cells and peritoneal exudate cells during infection with herpes simplex virus-1

1992 • 51 citations

Isolation of Human Immunodeficiency Virus Type 1 from Human Epidermis: Virus Replication and Transmission Studies

1992 • 51 citations

Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes.

1991 • 51 citations

Immunocompetent cells and epithelial cell modifications in molluscum contagiosum

1990 • 50 citations

The response of Langerhans cells in the cornea to herpetic keratitis

1987 • 50 citations

Langerhans cells at the sites of vaccinia virus inoculation

1976 • 49 citations

Detection of FMDV RNA amplified by the polymerase chain reaction (PCR)

1992 • 48 citations

Frequency of herpes simplex virus-specific murine cytotoxic T lymphocyte precursors in mitogen- and antigen-driven primary in vitro T cell responses.

1987 • 48 citations

The herpes simplex problem

1988 • 47 citations

Cytomembrane-Derived Birbeck Granules Transport Horseradish Peroxidase to the Endosomal Compartment in the Human Langerhans Cells

1992 • 46 citations

Prognostic value of Langerhans cells in the epidermis of HIV patients

1988 • 46 citations

Detection of Human Immunodeficiency Virus-DNA and RNA in the Skin of HIV-Infected Patients Using the Polymerase Chain Reaction

1991 • 46 citations

Contact Allergens Modulate the Expression of MHC Class II Molecules on Murine Epidermal Langerhans Cells by Endocytotic Mechanisms

1992 • 43 citations

Acute HIV-1 infection: clinical and biological study of 12 patients.

1990 • 43 citations

Endoscopic intratumoral injection of ok-432 and langerhans' cells in patients with gastric carcinoma

1988 • 43 citations

The effects of ultraviolet irradiation of the skin on herpes simplex virus infection: alteration in immune function mediated by epidermal cells and in the course of infection

1987 • 43 citations

Human Epidermal Langerhans Cells Express Integrins of the β1 Subfamily

1991 • 43 citations

Human Immunodeficiency Virus Infection and the Skin

1991 • 42 citations

Antigen Processing and Presentation by Epidermal Langerhans Cells: Induction of Immunity or Unresponsiveness

1990 • 41 citations

Immunity to herpes simplex virus type 2: viral antigen-presenting capacity of epidermal cells and its impairment by ultraviolet irradiation.

1986 • 40 citations

THE DETECTION OF HUMAN IMMUNODEFICIENCY VIRUS DNA IN DENDRITIC CELLS FROM THE JOINTS OF PATIENTS WITH ASEPTIC ARTHRITIS

1990 • 40 citations

Role of epidermal Langerhans cells in resistance to herpes simplex virus infection

1986 • 39 citations

In Vitro HIV-1 Entry and Replication in Langerhans Cells May Clarify the HIV-1 Genome Detection by PCR in Epidermis of Seropositive Patients

1992 • 37 citations

Role of epidermal Langerhans cells in viral infections

1988 • 35 citations

Differential Effects of Benzo[a]pyrene and Dimethylbenz[a]-anthracene on Langerhans Cell Distribution and Contact Sensitization in Murine Epidermis

1989 • 34 citations

T-cell subsets and langerhans cells in wart lesions

1983 • 31 citations

Herpetic stromal keratitis in mice: Less reversibility in the presence of Langerhans cells in the central cornea

1991 • 31 citations

Ultrastructural studies of spontaneously regressing plane warts. Langerhans cells show marked activation

1981 • 30 citations

Distribution of non‐lymphoid, inflammatory cells in chronic HBV infection

1990 • 29 citations

Murine epidermal antigen-presenting cells in primary and secondary T-cell proliferative responses to herpes simplex virus in vitro.

1991 • 28 citations

Galactose receptors and presentation of HIV envelope glycoprotein to specific human T cells.

1992 • 28 citations

Human immunodeficiency virus infection and the skin

1991 • 27 citations

Adhesion Molecules on the Plasma Membrane of Epidermal Cells. III. Keratinocytes and Langerhans Cells Constitutively Express the Lymphocyte Function-Associated Antigen 3

1991 • 27 citations

Effect of HIV on antigen presentation by dendritic cells and macrophages

1991 • 26 citations

Quantitative studies on langerhans cells in mouse corneal epithelium following infection with herpes simplex virus

1987 • 25 citations

Correction of human immunodeficiency virus-associated depression of delayed-type hypersensitivity (DTH) after zidovudine therapy: DTH, CD4+ T-cell numbers, and epidermal Langerhans cell density are independent variables

1990 • 25 citations

Role of Langerhans cells in the infection of the guinea-pig epidermis with foot-and-mouth disease virus

1985 • 24 citations

Morphology and membrane antigens of nonlymphoid accessory cells in oral hairy leukoplakia

1990 • 24 citations

The relationship of corneal Langerhans cells to herpes simplex antigens during dendritic keratitis

1989 • 23 citations

Dendritic cells and viruses

1988 • 23 citations

Role of Langerhans cells and other dendritic cells in disease states.

1993 • 22 citations

Interaction of Human Epidermal Langerhans Cells with HIV‐1 Viral Envelope Proteins (gp 120 and gp 160s) Involves a Receptor‐mediated Endocytosis Independent of the CD4 T4A Epitope

1991 • 21 citations

Dendritic cells and dinitrochlorobenzene (DNCB): a new treatment approach to AIDS

1991 • 21 citations

Stimulatory and suppressive effects of infection of dendritic cells with HIV-1

1991 • 20 citations

Role of Langerhans cells and other dendritic cells in viral diseases

1993 • 19 citations

Effect of orally administered aromatic retinoid on murine Langerhans cells

1987 • 19 citations

Assessment by Planimetry of Langerhans’ Cell Density in Penile Epithelium with Human Papillomavirus Infection: Changes Observed After Topical Treatment

1992 • 17 citations

Antigen presentation in patients with recrudescent orofacial herpes simplex virus infections

1990 • 17 citations

Antigen-presenting Capacity of Epidermal Cells Infected with Vaccinia Virus Recombinants Containing the Herpes Simplex Virus Glycoprotein D, and Protective Immunity

1989 • 17 citations

Suppression of contact sensitivity by local hyperthermia treatment due to reduced Langerhans cell population in mice

1989 • 16 citations

T6-positive Langerhans cells in diseased corneas.

1991 • 16 citations

Retinoic acid protects Langerhans' cells from the effects of the tumour promotor 12-O-tetradecanoylphorbol 13-acetate.

1989 • 15 citations

Langerhans cells in vaccinia virus infection in mouse skin

1989 • 14 citations

Ultraviolet Radiation, Langerhans' Cells, and Skin Cancer

1989 • 13 citations

Mechanism of HIV-1 Entry into CD4+ T Cells

1991 • 11 citations

Release of interferon gamma by epidermal langerhans cells

1988 • 10 citations

IL-1 production by T6 (CD1a) positive cord blood mononuclear cells (Langerhan's cell precursors?).

1989 • 10 citations

Effects of Murine Epidermal Langerhans Cells of Drugs Known to Cause Recrudescent Herpes Simplex Virus Infection in a Mouse Model

1991 • 9 citations

Crusted scabies in a patient with the acquired immunodeficiency syndrome

1990 • 8 citations

Stimulation of the recruitment of epidermal Langerhans cells by splenopentin

1990 • 8 citations

Reduced density and morphologic alteration of Ia and ADPase positive Langerhans cells after low-protein diet

1989 • 6 citations

Rationale for Anti-AIDS Chemotherapy Directed at HIV-1 Infected Dendritic Cells in Seropositive Individuals Prior to the Appearance of ARC and AIDS

1990 • 6 citations

Dendritic Cells in the Epidermis and the Lymph Nodes — A Review

1991 • 5 citations

HIV Infection of Skin Langerhans Cells

1991 • 4 citations

HIV Infection of Peripheral Blood Dendritic Cells

1991 • 4 citations

Involvement of Epidermal and Lymph Node Dendritic Cells in Skin HSV-1 Infection

1991 • 4 citations

Isolation of bovine epidermal langerhans cells and their maintenance in vitro

1992 • 3 citations

Langerhans Cell and Interdigitating Dendritic Cell Infection in African Swine Fever

1991 • 3 citations

[HIV envelope proteins are bound by human epidermal Langerhans cells by a binding site which differs from the site on the CD4 molecule, and are internalized by receptor endocytosis].

1989 • 3 citations

The distribution of viral antigens and Langerhans cells during zosteriform spread of herpes simplex virus to the skin of the mouse

1992 • 3 citations

Doses of uv radiation that modulate icam 1 expression and inhibit accessory cell function are cytotoxic for murine langerhans cells lc

1992 • 3 citations

Isotretinoin Therapy for Recurrent Herpes Simplex Lesions

1988 • 2 citations