Antigen Processing and Presentation by Epidermal Langerhans Cells: Induction of Immunity or Unresponsiveness

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB.

1980 • 983 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor

1989 • 505 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.

1983 • 400 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells

1989 • 389 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Structural Basis of Antibody Function

1983 • 371 citations

The Skin Immune System (SIS): Distribution and Immunophenotype of Lymphocyte Subpopulations in Normal Human Skin

1987 • 341 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation

1987 • 297 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINS

1988 • 277 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Structure, Function, and Serology of the T-Cell Antigen Receptor Complex

1987 • 264 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

Antigen presentation by murine epidermal langerhans cells and its alteration by ultraviolet B light.

1981 • 255 citations

Proton-Translocating ATPases

1986 • 255 citations

Studies on Human Epidermal Langerhans Cells

1980 • 244 citations

Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones.

1988 • 241 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

Antigen conformation determines processing requirements for T-cell activation.

1984 • 181 citations

Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells.

1986 • 174 citations

Studies on hypersensitivity. II. Delayed hypersensitivity to denatured proteins in guinea pigs.

1959 • 163 citations

Antigen Uptake and Accumulation in Antigen‐Specific B Cells

1987 • 148 citations

Mechanisms of Cutaneous Inflammation

1989 • 148 citations

An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.

1989 • 143 citations

Depletion of epidermal langerhans cells and Ia immunogenicity from tape-stripped mouse skin.

1982 • 141 citations

Role of Interferon-? in Cutaneous Trafficking of Lymphocytes With Emphasis on Molecular and Cellular Adhesion Events

1988 • 138 citations

Antigen processing at the molecular level

1987 • 137 citations

Immunologic Tolerance: Collaboration Between Antigen and Lymphokines

1989 • 135 citations

Characterization of the physical interaction between antigen-specific B and T cells.

1986 • 124 citations

Antigen Processing for Presentation to T Lymphocytes: Function, Mechanisms, and Implications for the T-Cell Repertoire

1988 • 105 citations

Induction of murine interleukin 1: stimuli and responsive primary cells.

1987 • 103 citations

T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing.

1988 • 100 citations

Targeted antigen presentation using crosslinked antibody heteroaggregates.

1987 • 93 citations

The molecular basis of the requirement for antigen processing of pigeon cytochrome c prior to T cell activation.

1985 • 89 citations

Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity

1989 • 86 citations

T-cell recognition of antigen and the Ia molecule as a ternary complex

1986 • 85 citations

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants.

1985 • 84 citations

Antigen‐presenting cell function of dendritic cells and macrophages in proliferative T cell responses to soluble and particulate antigens

1986 • 78 citations

A comparison of the stimulatory activities of lymphoid dendritic cells and macrophages in T proliferative responses to various antigens.

1984 • 74 citations

Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1.

1986 • 73 citations

Mechanisms of Antigen Processing

1988 • 66 citations

Cationization of protein antigens. IV. Increased antigen uptake by antigen-presenting cells.

1988 • 65 citations

Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody.

1987 • 60 citations

The Biochemistry and Cell Biology of Antigen Processing

1988 • 59 citations

Theoretical and Practical Aspects of B‐Cell Activation: Murine and Human Systems

1987 • 58 citations

Anti-idiotypic T cells suppress rejection of renal allografts in rats

1985 • 53 citations

Antigen-reactive cloned helper T cells. I. Unresponsiveness to antigenic restimulation develops after stimulation of cloned helper T cells.

1984 • 53 citations

Immune mechanisms in cutaneous disease

1990 • 50 citations

Oligopeptide antigens of the angiotensin lineage compete for presentation by paraformaldehyde-treated accessory cells to T cells.

1986 • 48 citations

Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T cells.

1987 • 46 citations

Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide.

1988 • 44 citations

Conformational‐dependent recognition of influenza virus hemagglutinin by murine T helper clones

1986 • 43 citations

Accessory functions and mutual cooperation of murine macrophages and dendritic cells

1983 • 39 citations

Processing and Presentation of Antigens

1988 • 33 citations

Facts on the Fragmentation of Antigens in Presenting Cells, on the Association of Antigen Fragments with MHC Molecules in Cell‐Free Systems, and Speculation on the Cell Biology of Antigen Processing

1988 • 24 citations

The Sensitization Phase of T‐Cell‐Mediated Immunitya

1988 • 24 citations

Analysis of proteolytic processing during specific antigen presentation

1987 • 21 citations

The low-dose model of UVB-induced immunosuppression.

1988 • 19 citations

Functional clonal deletion and suppression as complementary mechanisms operative in adult hapten-induced cytotoxic T cell tolerance.

1983 • 19 citations

Immunology: Exclusive immunoglobulin genes

1984 • 14 citations

Molecular sorting during endocytosis.

1987 • 12 citations

Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.

1986 • 12 citations

Antigen presentation by cells that are not of bone marrow origin.

1989 • 11 citations

What T Cells See and How They See It

1988 • 8 citations

Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.

1983 • 7 citations