Contact Allergens Modulate the Expression of MHC Class II Molecules on Murine Epidermal Langerhans Cells by Endocytotic Mechanisms

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

1990 • 254 citations

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.

1990 • 238 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

1990 • 210 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Selective interaction of Ni with an MHC-bound peptide.

1991 • 147 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules

1989 • 94 citations

Human epidermal Langerhans cells cointernalize by receptor-mediated endocytosis "nonclassical" major histocompatibility complex class I molecules (T6 antigens) and class II molecules (HLA-DR antigens).

1987 • 92 citations

Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange.

1989 • 87 citations

Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing.

1990 • 81 citations

Mouse B lymphocyte specific endocytosis and recycling of MHC class II molecules.

1990 • 75 citations

Inhibition by brefeldin A of presentation of exogenous protein antigens to MHC class II-restricted T cells

1990 • 74 citations

Lack of detectable endocytosis of B lymphocyte MHC class II antigens using an antibody-independent technique.

1990 • 66 citations

MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A.

1990 • 61 citations

Differential Effects of Structurally Unrelated Chemical Irritants on the Density and Morphology of Epidermal CD1+Cells

1990 • 55 citations

Genetic control of contact sensitivity to oxazolone in inbred, H‐2 congenic and intra‐H‐2 recombinant strains of mice

1977 • 51 citations

Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells

1991 • 42 citations

Internalization and Acidification of Surface HLA-DR Molecules by Epidermal Langerhans Cells: A Paradigm for Antigen Processing

1990 • 39 citations

Endocytosis and recycling of MHC-encoded class II molecules by mouse B lymphocytes.

1990 • 24 citations

Successful Contact Sensitization to Chromate in Mice

1988 • 18 citations

Internalization of Ia molecules by antigen-presenting B cells is limited.

1990 • 8 citations