Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

1990 • 707 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 • 576 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells.

1987 • 523 citations

Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes

1976 • 510 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Cytokine Modulation of Keratinocyte Cytokines

1990 • 345 citations

Langerhans cells form a reticuloepithelial trap for external contact antigens

1976 • 283 citations

Evidence for an Epidermal Cytokine Network

1990 • 278 citations

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.

1990 • 238 citations

Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation.

1990 • 227 citations

Dendritic cells and the initiation of contact sensitivity to fluorescein isothiocyanate.

1986 • 221 citations

Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues.

1988 • 215 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

The role of dendritic cells in the initiation of immune responses to contact sensitizers

1985 • 146 citations

Ultraviolet B light-induced alterations in epidermal Langerhans cells are mediated in part by tumor necrosis factor-alpha.

1990 • 127 citations

The expression and modulation of IL-1 alpha in murine keratinocytes.

1988 • 123 citations

Keratinocyte Derived T-Cell Growth Factor (KTGF) Is Identical to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)

1988 • 102 citations

Dendritic Cell Accumulation in Draining Lymph Nodes during the Induction Phase of Contact Allergy in Mice

1989 • 92 citations

Phenotypic characteristics of antigen-bearing cells in the draining lymph nodes of contact sensitized mice.

1990 • 85 citations

MHC class II expression by Langerhans' cells and lymph node dendritic cells: possible evidence for maturation of Langerhans' cells following contact sensitization.

1991 • 84 citations

Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes.

1991 • 51 citations

Keratinocyte-expression of interleukin-6 but not of tumour necrosis factor-alpha is increased in the allergic and the irritant patch test reaction.

1991 • 39 citations

The role of dendritic cells in the initiation of immune responses to contact sensitizers

1985 • 37 citations

Interleukin-1 decreases the number of Ia+ epidermal dendritic cells but increases their expression of Ia antigen.

1990 • 32 citations