Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Principles and Practice of Ophthalmology

1981 • 1,087 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

The Function of Myosin and Myosin Light Chain Kinase Phosphorylation in Smooth Muscle

1985 • 1,052 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

The regulation of trabecular meshwork and ciliary muscle contractility

2000 • 317 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Functional morphology of the trabecular meshwork in primate eyes

1999 • 254 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

Cytoskeletal involvement in the regulation of aqueous humor outflow.

2000 • 231 citations

Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts.

1993 • 186 citations

Isolation, culture, and characterization of endothelial cells from Schlemm's canal.

1998 • 163 citations

Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions

1999 • 159 citations

Acto-myosin drug effects and aqueous outflow function.

1999 • 132 citations

H-7 Disrupts the Actin Cytoskeleton and Increases Outflow Facility

1998 • 123 citations

Localization of smooth muscle and nonmuscle actin isoforms in the human aqueous outflow pathway.

1992 • 100 citations

Influence of ethacrynic acid on outflow facility in the monkey and calf eye.

1987 • 83 citations

Ethacrynic acid induces reversible shape and cytoskeletal changes in cultured cells.

1992 • 73 citations

Cytochalasin B and D dose-outflow facility response relationships in the cynomolgus monkey.

1982 • 70 citations

Latrunculins' effects on intraocular pressure, aqueous humor flow, and corneal endothelium.

2000 • 65 citations

Morphological and functional effects of Na2EDTA on the outflow routes for aqueous humor in monkeys

1987 • 44 citations

Molecular decipherment of Rho effector pathways regulating tight-junction permeability

2000 • 36 citations

Nonsulfhydryl-reactive phenoxyacetic acids increase aqueous humor outflow facility.

1997 • 36 citations

Hydraulic pressure stimulates adenosine 3',5'-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal.

1999 • 32 citations

Hypotony and aqueous humor dynamics in myotonic dystrophy.

1982 • 28 citations

A Mechanism for Trabecular Meshwork Cell Retraction: Ethacrynic Acid Initiates the Dephosphorylation of Focal Adhesion Proteins

1997 • 27 citations

Morphology and function of the aqueous outflow system in monkey eyes perfused with sulfhydryl reagents.

1983 • 23 citations

Advances in Glaucoma Diagnosis and Therapy for the Next Millennium: New Drugs for Trabecular and Uveoscleral Outflow

1999 • 19 citations

Ocular hypotony in myotonic dystrophy

1983 • 11 citations