Pitavastatin Enhanced BMP-2 and Osteocalcin Expression by Inhibition of Rho-Associated Kinase in Human Osteoblasts

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Stimulation of Bone Formation in Vitro and in Rodents by Statins

1999 • 1,751 citations

Therapeutic Approaches to Bone Diseases

2000 • 1,732 citations

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

2000 • 1,427 citations

Statins as a newly recognized type of immunomodulator

2000 • 1,371 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

HMG-CoA Reductase Inhibitors and the Risk of Fractures

2000 • 452 citations

Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis.

1996 • 448 citations

HMG-CoA Reductase Inhibitors and the Risk of Hip Fractures in Elderly Patients

2000 • 424 citations

Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women

2000 • 393 citations

Inhibition of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Blocks Hypoxia-mediated Down-regulation of Endothelial Nitric Oxide Synthase

1997 • 393 citations

3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Attenuate Vascular Smooth Muscle Proliferation by Preventing Rho GTPase-induced Down-regulation of p27

1999 • 389 citations

Simvastatin Promotes Osteoblast Differentiation and Mineralization in MC3T3-E1 Cells

2001 • 359 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Bone Morphogenetic Protein-2

1996 • 311 citations

Compactin and Simvastatin, but Not Pravastatin, Induce Bone Morphogenetic Protein-2 in Human Osteosarcoma Cells

2000 • 281 citations

The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

1998 • 265 citations

Anabolic Therapy for Osteoporosis

2001 • 206 citations

Direct Vascular Effects of HMG-CoA Reductase Inhibitors

2000 • 161 citations

Glucocorticoid-induced Osteoporosis

2000 • 135 citations

Induction of Cyclooxygenase-2 by Angiotensin II in Cultured Rat Vascular Smooth Muscle Cells

2000 • 133 citations

Nonradioisotopic Quantitative RT-PCR to Detect Changes in mRNA Levels during Early Mouse Embryo Development

1993 • 106 citations

Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1997 • 103 citations

Regulated Expression of the Bone-Specific Osteocalcin Gene by Vitamins and Hormones

1998 • 86 citations

1,25-Dihydroxyvitamin D3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts.

1996 • 84 citations

Low level of glucocorticoid receptor messenger ribonucleic acid in pituitary adenomas manifesting Cushing's disease with resistance to a high dose‐dexamethasone suppression test

1998 • 32 citations

What Can We Learn from Bone Biology for the Treatment for Osteoporosis?

1999 • 8 citations