Critical Role of Rho-Kinase and MEK/ERK Pathways for Angiotensin II–Induced Plasminogen Activator Inhibitor Type-1 Gene Expression

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

1991 • 808 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Angiotensin Receptors and Their Antagonists

1996 • 568 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries.

1992 • 547 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Angiotensin II Activates RhoA in Cardiac Myocytes

1998 • 224 citations

Proteinases and extracellular remodeling

1989 • 224 citations

Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells

1992 • 210 citations

Downregulation of Angiotensin II Type 1 Receptor Gene Transcription by Nitric Oxide

1998 • 208 citations

Rho Family Small G Proteins Play Critical Roles in Mechanical Stress–Induced Hypertrophic Responses in Cardiac Myocytes

1999 • 186 citations

Induction of Interleukin-6 Expression by Angiotensin II in Rat Vascular Smooth Muscle Cells

1999 • 178 citations

Angiotensin II increases plasminogen activator inhibitor type 1 and tissue-type plasminogen activator messenger RNA in cultured rat aortic smooth muscle cells.

1994 • 177 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Involvement of PYK2 in Angiotensin II Signaling of Vascular Smooth Muscle Cells

1999 • 168 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

The effects of the selective ROCK inhibitor, Y27632, on ET‐1‐induced hypertrophic response in neonatal rat cardiac myocytes – possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy

1999 • 113 citations

Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs

2000 • 92 citations

REGULATION OF PLASMINOGEN ACTIVATOR INHIBITOR-1 mRNA IN HUMAN ENDOTHELIAL CELLS

1987 • 87 citations

The Small GTP-Binding Protein Rho Potentiates AP-1 Transcription in T Cells

1998 • 87 citations

Induction of Plasminogen Activator Inhibitor Type 1 and Type 1 Collagen Expression in Rat Cardiac Microvascular Endothelial Cells by Interleukin-1 and Its Dependence on Oxygen-Centered Free Radicals

1998 • 84 citations

The organization of the human‐plasminogen‐activator‐inhibitor‐1 gene

1988 • 78 citations

Regulation of Plasminogen Activator Inhibitor-1 mRNA in Human Endothelial Cells

1988 • 65 citations

Angiotensin II‐induced vascular smooth muscle cell hypertrophy: PDGF A‐chain mediates the increase in cell size

1993 • 56 citations

Increased intramural expression of plasminogen activator inhibitor type 1 after balloon injury: A potential progenitor of restenosis

1994 • 52 citations

Plasminogen activator inhibitor-1: a common denominator in cardiovascular disease.

1998 • 52 citations

Downregulation of Angiotensin II Type 1 Receptor by All- trans Retinoic Acid in Vascular Smooth Muscle Cells

2000 • 47 citations

Cyclic Nucleotide Regulation of Type-1 Plasminogen Activator-Inhibitor mRNA Stability in Rat Hepatoma Cells

1998 • 37 citations

Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells

1991 • 35 citations

5 Fibrinolysis and atherosclerosis

1995 • 35 citations