Cannabinoid receptors and the regulation of immune response

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

Determination and characterization of a cannabinoid receptor in rat brain.

1988 • 2,339 citations

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

1964 • 2,296 citations

Cannabinoid receptor localization in brain.

1990 • 2,248 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

1991 • 2,139 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1994 • 1,743 citations

Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations

1995 • 1,689 citations

Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain

1997 • 992 citations

Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.

1995 • 838 citations

SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.

1998 • 679 citations

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1991 • 679 citations

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.

1995 • 625 citations

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a G_sLinkage to the CB1 Receptor

1997 • 623 citations

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

1995 • 535 citations

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

2000 • 534 citations

Neuronal localization of cannabinoid receptors in the basal ganglia of the rat

1991 • 515 citations

Pharmacology of Cannabinoid Receptor Ligands

1999 • 481 citations

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

1997 • 457 citations

Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension

1998 • 409 citations

Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannabinoid CB2 Receptor

2000 • 370 citations

ACUTE ANTERIOR UVEITIS AND HL-A 27

1974 • 366 citations

Cannabinoid‐receptor expression in human leukocytes

1993 • 361 citations

Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.

2000 • 354 citations

Cannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune System

1997 • 345 citations

Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB¹ receptors on peripheral sympathetic nerves

1996 • 329 citations

An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing

1995 • 321 citations

Functional CB1 cannabinoid receptors in human vascular endothelial cells

2000 • 314 citations

Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor

1999 • 306 citations

Cannabinoids as Therapeutic Agents

2019 • 299 citations

Biosynthesis and inactivation of the endocannabinoid 2‐arachidonoylglycerol in circulating and tumoral macrophages

1999 • 295 citations

Internalization and Recycling of the CB1 Cannabinoid Receptor

1999 • 292 citations

Agonist Selective Regulation of G Proteins by Cannabinoid CB₁and CB₂Receptors

1999 • 289 citations

Signaling Pathway Associated with Stimulation of CB2 Peripheral Cannabinoid Receptor

1996 • 277 citations

Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids.

1994 • 270 citations

Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains

1994 • 269 citations

Distinct Domains of the CB1 Cannabinoid Receptor Mediate Desensitization and Internalization

1999 • 254 citations

The Health Effects of Cannabis

1999 • 249 citations

Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.

1992 • 243 citations

Essential fatty acids and eicosanoids

1993 • 239 citations

Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells

2000 • 234 citations

Cannabinoid receptors and immunity

1998 • 232 citations

LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.

1998 • 223 citations

The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.

1999 • 219 citations

THE IDENTIFICATION OF N-(2-HYDROXYETHYL)-PALMITAMIDE AS A NATURALLY OCCURRING ANTI-INFLAMMATORY AGENT

1957 • 205 citations

Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system

1999 • 205 citations

A proposed autacoid mechanism controlling mastocyte behaviour

1993 • 202 citations

Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor

1996 • 200 citations

Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor.

2000 • 199 citations

The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling.

1995 • 192 citations

Marijuana, immunity and infection

1998 • 192 citations

Δ9 Tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells

1998 • 186 citations

Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation.

1996 • 183 citations

SR 141716A Acts as an Inverse Agonist to Increase Neuronal Voltage-Dependent Ca²⁺Currents by Reversal of Tonic CB1 Cannabinoid Receptor Activity

1998 • 180 citations

Cannabinoid Receptor Agonist Efficacy for Stimulating [35S]GTPγS Binding to Rat Cerebellar Membranes Correlates with Agonist-induced Decreases in GDP Affinity

1998 • 178 citations

The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide

1995 • 175 citations

Stimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells

1995 • 173 citations

Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice

2000 • 168 citations

Cannabinoids enhance human B‐cell growth at low nanomolar concentrations

1995 • 168 citations

Modulation and Functional Involvement of CB2 Peripheral Cannabinoid Receptors During B-Cell Differentiation

1998 • 165 citations

Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine

1996 • 163 citations

Influence of fatty acid ethanolamides and Δ9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells

1997 • 160 citations

Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.

1994 • 158 citations

Protein Kinase C Disrupts Cannabinoid Actions by Phosphorylation of the CB1 Cannabinoid Receptor

1998 • 150 citations

Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

1998 • 150 citations

The CB1 Cannabinoid Receptor Can Sequester G-Proteins, Making Them Unavailable to Couple to Other Receptors

1999 • 148 citations

Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system

1999 • 146 citations

(—)-Δ9-Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase

1996 • 140 citations

Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection

1994 • 139 citations

Molecular Aspects of Cannabinoid Receptors

1997 • 137 citations

Cannabinoid Inhibition of Adenylate Cyclase-mediated Signal Transduction and Interleukin 2 (IL-2) Expression in the Murine T-cell Line, EL4.IL-2

1996 • 136 citations

Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes.

1995 • 134 citations

Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice

1998 • 131 citations

Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism

1994 • 131 citations

Evidence for the presence of cannabinoid CB₁ receptors in mouse urinary bladder

1996 • 121 citations

Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein

1995 • 121 citations

Relationships Between Ligand Affinities for the Cerebellar Cannabinoid Receptor CB1 and the Induction of GDP/GTP Exchange

1999 • 121 citations

Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus

1979 • 119 citations

Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation.

1999 • 114 citations

Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes.

1998 • 112 citations

Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation.

1999 • 110 citations

Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system

1998 • 108 citations

The endogenous cannabinoid anandamide potentiates interleukin‐6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor‐mediated pathway

1998 • 108 citations

Suppression of Interleukin-2 by the Putative Endogenous Cannabinoid 2-Arachidonyl-Glycerol Is Mediated through Down-regulation of the Nuclear Factor of Activated T Cells

1998 • 106 citations

Anandamide suppresses nitric oxide and TNF-α responses to Theilerʼs virus or endotoxin in astrocytes

1997 • 106 citations

Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells

1997 • 104 citations

Isolation and expression of a mouse CB1 cannabinoid receptor gene

1997 • 103 citations

Regulation of Peripheral Cannabinoid Receptor CB2Phosphorylation by the Inverse Agonist SR 144528

1999 • 102 citations

Drugs of abuse and immune function

1990 • 100 citations

Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor

1999 • 100 citations

Involvement of the Carboxyl Terminus of the Third Intracellular Loop of the Cannabinoid CB1 Receptor in Constitutive Activation of G_s

1999 • 98 citations

Genomic and Functional Changes Induced by the Activation of the Peripheral Cannabinoid Receptor CB2 in the Promyelocytic Cells HL-60

2000 • 94 citations

Marijuana components suppress induction and cytolytic function of murine cytotoxic T cells in vitro and in vivo

1991 • 93 citations

Effects of CB₁ cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity

1999 • 93 citations

Functional CB1 cannabinoid receptors in human vascular endothelial cells

2000 • 91 citations

Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells

2000 • 89 citations

Tetrahydrocannabinol-Induced Suppression of Macrophage Spreading and Phagocytic Activity In Vitro

1986 • 83 citations

The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor‐independent pathway in hematopoietic cell lines

1998 • 81 citations

Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events.

1993 • 79 citations

Marijuana effects on immunity: Suppression of human natural killer cell activity by delta-9-tetrahydrocannabinol

1986 • 78 citations

delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages.

1995 • 74 citations

Essential Fatty Acids and Eicosanoids: Invited Papers from the Third International Congress

1993 • 74 citations

Inhibition of natural killer cell function by Marijuana components

1987 • 73 citations

Tetrahydrocannabinol inhibition of macrophage nitric oxide production

1996 • 73 citations

Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila.

1993 • 72 citations

Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation.

1996 • 71 citations

THE EFFECT OF EGG YOLK IN DIETS ON ANAPHYLACTIC ARTHRITIS (PASSIVE ARTHUS PHENOMENON) IN THE GUINEA PIG

1954 • 71 citations

Cannabinoid receptor CB1 activates the Na⁺/H⁺ exchanger NHE‐1 isoform via G_i‐mediated mitogen activated protein kinase signaling transduction pathways

1999 • 70 citations

Anandamide inhibits macrophage-mediated killing of tumor necrosis factor-sensitive cells

1995 • 69 citations

In vitro and in vivo suppressive effects of delta-9-tetrahydrocannabinol on interferon production by murine spleen cells

1986 • 69 citations

A Mutation in the Second Transmembrane Region of the CB1 Receptor Selectively Disrupts G Protein Signaling and Prevents Receptor Internalization

1999 • 66 citations

Δ9-tetrahydrocannabinol selectivity inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function

1993 • 66 citations

Inhibition of the Cyclic AMP Signaling Cascade and Nuclear Factor Binding to CRE and κB Elements by Cannabinol, a Minimally CNS-Active Cannabinoid

1998 • 65 citations

Inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse and human macrophages

1992 • 63 citations

Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors

1998 • 62 citations

Anandamide and other N-acylethanolamines in mouse peritoneal macrophages

1997 • 62 citations

Differential Receptor–G-Protein Coupling Evoked by Dissimilar Cannabinoid Receptor Agonists

1998 • 61 citations

9-Tetrahydrocannabinol Decreases Alpha/Beta Interferon Response to Herpes Simplex Virus Type 2 in the B6C3F1 Mouse

1986 • 59 citations

Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain

1997 • 59 citations

Intact humoral and cell-mediated immunity in chronic marijuana smoking

1976 • 58 citations

Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies

1998 • 58 citations

Delta-9-Tetrahydrocannabinol Decreases Host Resistance to Herpes Simplex Virus Type 2 Vaginal Infection in the B6C3F1 Mouse

1985 • 56 citations

Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes.

1999 • 54 citations

Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression

1996 • 53 citations

Differential Superactivation of Adenylyl Cyclase Isozymes after Chronic Activation of the CB₁Cannabinoid Receptor

2000 • 53 citations

Effects of cannabinoids and cocaine on the mitogen-induced transformations of lymphocytes of human and mouse origins

1992 • 51 citations

Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications

1998 • 51 citations

Effect of 9-Tetrahydrocannabinol on Herpes Simplex Virus Type 2 Vaginal Infection in the Guinea Pig

1986 • 50 citations

AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun

2000 • 49 citations

Interleukin-1 synergy with phosphoinositide pathway agonists for induction of interleukin-2 gene expression: molecular basis of costimulation.

1990 • 48 citations

Δ9-tetrahydrocannabinol (THC) modulates IL-1 bioactivity in human monocyte/macrophage cell lines

1994 • 44 citations

Marijuana, Receptors and Immunomodulation

1995 • 44 citations

Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells.

2000 • 44 citations

Biosynthesis and turnover of anandamide and other N‐acylethanolamines in peritoneal macrophages

1999 • 41 citations

Marijuana and immunity: Tetrahydrocannabinol-mediated inhibition of growth and phagocytic activity of the murine macrophage cell line, P388D1

1992 • 41 citations

FACTOR IN ARACHIS OIL DEPRESSING SENSITIVITY TO TUBERCULIN IN B.C.G.-INFECTED GUINEAPIGS

1956 • 41 citations

Cannabinoid Receptors and the Cytokine Network

1998 • 40 citations

Cyclic AMP Is an Essential Factor in Immune Responses

1995 • 40 citations

Suppression of Human Macrophage Function In Vitro by δ9-Tetrahydrocannabinol

1991 • 39 citations

Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens

1996 • 37 citations

Cannabinoid Receptor Expression in Immune Cells

1996 • 34 citations

Anti-inflammatory properties of N(2-hydroxyethyl) palmitamide.

1971 • 31 citations

Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells

2000 • 29 citations

Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds

1998 • 29 citations

Altered Serum Immunoglobulin Concentration in Chronic Marijuana Smokers

1991 • 28 citations

Effects of CTx and 8-Bromo-cAMP on LPS-Induced Gene Expression of Cytokines in Murine Peritoneal Macrophages

2000 • 27 citations

Stereospecific Effects of (–)- and (+)-7-Hydroxy-Delta-6-Tetrahydrocannabinol-Dimethylheptyl on the Immune System of Mice

1989 • 27 citations

The Brain Immune Axis and Substance Abuse

1995 • 27 citations

Delta-9-tetrahydrocannabinol suppresses tumor necrosis factor α maturation and secretion but not its transcription in mouse macrophages

1996 • 26 citations

Inhibition of macrophage inducible protein expression by delta-9-tetrahydrocannabinol

1994 • 25 citations

Peripheral Blood Lymphocyte Subpopulations and Mitogen Responsiveness in Tobacco and Marijuana Smokers

1988 • 24 citations

Cannabinoid Receptor Agonists Enhance Syncytia Formation in MT-2 Cells Infected with Cell Free HIV-1MN

1998 • 24 citations

Inhibition of protein kinase A and cyclic AMP response element (CRE)-specific transcription factor binding by Δ9-tetrahydrocannabinol (Δ9-THC)

1997 • 19 citations

Non-specific resistance induced by palmitoylethanolamide

1972 • 15 citations

The effect of N-(2-hydroxyethyl)-palmitamide on delayed hypersensitivity in guinea-pig

1973 • 14 citations

[New possibilities of increasing non-specific resistance].

1967 • 11 citations

Characterization of cannabinoid receptors in the spleen and in mast cells

1998 • 7 citations

Cannabinoid Stimulation of Arachidonate Metabolism in Human Peripheral Blood Mononuclear Leukocytes

1995 • 1 citations