Internalization and Recycling of the CB1 Cannabinoid Receptor

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

1998 • 1,549 citations

Pharmacology of cannabinoid CB1 and CB2 receptors

1997 • 1,448 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a G_sLinkage to the CB1 Receptor

1997 • 623 citations

Cannabinoids Inhibit N- and P/Q-Type Calcium Channels in Cultured Rat Hippocampal Neurons

1997 • 546 citations

Health aspects of cannabis

1987 • 495 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

The Role of Sequestration in G Protein-coupled Receptor Resensitization

1997 • 356 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

1996 • 327 citations

The Perceived Effects of Smoked Cannabis on Patients with Multiple Sclerosis

1997 • 326 citations

Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin.

1985 • 309 citations

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.

1994 • 228 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

A Phase II Study of Delta-9-Tetrahydrocannabinol for Appetite Stimulation in Cancer-Associated Anorexia

1994 • 211 citations

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

1995 • 209 citations

Sequestration of the δ Opioid Receptor

1996 • 198 citations

Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization

1997 • 193 citations

Clinical Relevance of Cannabis Tolerance and Dependence

1981 • 188 citations

Cannabinoid Receptor Agonist Efficacy for Stimulating [35S]GTPγS Binding to Rat Cerebellar Membranes Correlates with Agonist-induced Decreases in GDP Affinity

1998 • 178 citations

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.

1995 • 176 citations

Medicinal Applications of Delta-9-Tetrahydrocannabinol and Marijuana

1997 • 157 citations

Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.

1996 • 154 citations

Protein Kinase C Disrupts Cannabinoid Actions by Phosphorylation of the CB1 Cannabinoid Receptor

1998 • 150 citations

δ and κ Opioid Receptors Are Differentially Regulated by Dynamin-dependent Endocytosis When Activated by the Same Alkaloid Agonist

1997 • 139 citations

Molecular Aspects of Cannabinoid Receptors

1997 • 137 citations

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.

1992 • 129 citations

Two Homologous Phosphorylation Domains Differentially Contribute to Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor

1997 • 116 citations

Thr353, Located within the COOH-terminal Tail of the ´ Opiate Receptor, Is Involved in Receptor Down-regulation

1996 • 105 citations

Arrestin-independent Internalization of the m1, m3, and m4 Subtypes of Muscarinic Cholinergic Receptors

1998 • 105 citations

Phosphorylation of Four Amino Acid Residues in the Carboxyl Terminus of the Rat Somatostatin Receptor Subtype 3 Is Crucial for Its Desensitization and Internalization

1997 • 95 citations

Influence of the Cytosolic Carboxyl Termini of Human B1 and B2 Kinin Receptors on Receptor Sequestration, Ligand Internalization, and Signal Transduction

1998 • 92 citations

Receptor Subtype-specific Regulation of Muscarinic Acetylcholine Receptor Sequestration by Dynamin

1998 • 88 citations

Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes

1998 • 79 citations

A Constitutively Internalizing and Recycling Mutant of the μ‐Opioid Receptor

1997 • 68 citations

Agonist-induced Sequestration, Recycling, and Resensitization of Platelet-activating Factor Receptor

1998 • 62 citations

G Protein–Coupled Receptors and Receptor Kinases: From Molecular Biology to Potential Therapeutic Applications

1996 • 44 citations

G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration

1996 • 44 citations

Tolerance to and dependence on psychotropic cannabinoids

1992 • 39 citations

Deletion analysis of the m4 muscarinic acetylcholine receptor

1994 • 35 citations