Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1991 • 679 citations

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.

1995 • 625 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

1992 • 458 citations

Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.

1986 • 446 citations

In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C

1989 • 389 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in Lymphocytes

1972 • 381 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Cannabinoid‐receptor expression in human leukocytes

1993 • 361 citations

Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes.

1984 • 353 citations

Cannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune System

1997 • 345 citations

An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing

1995 • 321 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Cyclic adenosine 3′,5′-monophosphate in human lymphocytes. Alterations after phytohemagglutinin stimulation

1971 • 310 citations

Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes.

1985 • 248 citations

Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.

1992 • 243 citations

mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.

1990 • 237 citations

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

1989 • 220 citations

The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling

1995 • 208 citations

Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines.

1993 • 188 citations

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase

1995 • 186 citations

Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation.

1996 • 183 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.

1994 • 158 citations

Requirement for cAMP-PKA Pathway Activation by M Phase-Promoting Factor in the Transition from Mitosis to Interphase

1996 • 137 citations

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

1995 • 137 citations

Nucleotide sequence of a human cannabinoid receptor cDNA

1990 • 137 citations

Cannabinoid Inhibition of Adenylate Cyclase-mediated Signal Transduction and Interleukin 2 (IL-2) Expression in the Murine T-cell Line, EL4.IL-2

1996 • 136 citations

Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism

1994 • 131 citations

Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency.

1990 • 111 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter

1995 • 100 citations

cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

1988 • 97 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

1995 • 84 citations

Role of protein kinase a in LPS-induced activation of NF-κB proteins of a mouse macrophage-like cell line, J774

1993 • 79 citations

Type I cyclic AMP-dependent protein kinase as a positive effector of growth.

1978 • 75 citations

Δ9-tetrahydrocannabinol selectivity inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function

1993 • 66 citations

Inhibition of adenylate cyclase.

1985 • 65 citations

Inhibition of human B cell activation by diterpine forskolin: interference with B cell growth factor-induced G1 to S transition of the B cell cycle.

1984 • 57 citations

Protein kinase C in tumoricidal activation of mouse macrophage cell lines

1991 • 56 citations

Evidence for the existence of specific cannabinoid binding sites

1978 • 49 citations

Interleukin-1 synergy with phosphoinositide pathway agonists for induction of interleukin-2 gene expression: molecular basis of costimulation.

1990 • 48 citations

Inhibition of adenylate cyclase by Δ9-Tetrahydrocannabinol in mouse spleen cells: A potential mechanism for cannabinoid- mediated immunosuppression

1992 • 48 citations

Nitric oxide synthesis in rat peritoneal macrophages is induced by IgE/DNP complexes and cyclic AMP analogues. Evidence in favor of a common signaling mechanism.

1995 • 45 citations

Cyclic AMP Is an Essential Factor in Immune Responses

1995 • 40 citations

Studies on lidocaine-induced kindling

1992 • 33 citations

Contrasting effect of delta-9-tetrahydrocannabinol on IL-2 activity in spleen and lymph node cells of mice of different ages

1993 • 26 citations

Expression of functional glucagon receptors on lymphoid cells

1996 • 16 citations

Flow‐cytometric detection of the RIα subunit of type I cAMP‐dependent protein kinase in human cells

1994 • 14 citations

Transient CRE- and κB site-binding is cross-regulated by cAMP-dependent protein kinase and a protein phosphatase in mouse splenocytes

1997 • 10 citations