Cannabinoid Receptor Agonist Efficacy for Stimulating [35S]GTPγS Binding to Rat Cerebellar Membranes Correlates with Agonist-induced Decreases in GDP Affinity

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Determination and characterization of a cannabinoid receptor in rat brain.

1988 • 2,339 citations

Cannabinoid receptor localization in brain.

1990 • 2,248 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.

1992 • 694 citations

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a G_sLinkage to the CB1 Receptor

1997 • 623 citations

Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor

1995 • 619 citations

Cannabinoid Receptor Agonists Inhibit Glutamatergic Synaptic Transmission in Rat Hippocampal Cultures

1996 • 604 citations

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1996 • 555 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Pharmacology of Cannabinoid Receptors

1995 • 485 citations

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

1997 • 457 citations

In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.

1995 • 450 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1995 • 441 citations

Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.

1993 • 440 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.

1983 • 380 citations

The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.

1996 • 379 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells

1993 • 356 citations

An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing

1995 • 321 citations

Effects of Chronic Treatment with Δ⁹-Tetrahydrocannabinol on Cannabinoid-Stimulated [³⁵S]GTPγS Autoradiography in Rat Brain

1996 • 303 citations

Anandamide, a Brain Endogenous Compound, Interacts Specifically with Cannabinoid Receptors and Inhibits Adenylate Cyclase

1993 • 297 citations

Pharmacologic analysis of drug-receptor interaction

1994 • 270 citations

The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins.

1986 • 261 citations

Cannabinoid Receptors and Modulation of Cyclic AMP Accumulation in the Rat Brain

1990 • 209 citations

μ-Opioid Receptor-Stimulated Guanosine-5′-O-(γ-thio)-triphosphate Binding in Rat Thalamus and Cultured Cell Lines: Signal Transduction Mechanisms Underlying Agonist Efficacy

1997 • 202 citations

Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.

1996 • 199 citations

Regional Differences in Cannabinoid Receptor/G-protein Coupling in Rat Brain

1997 • 197 citations

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase

1995 • 186 citations

Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

1989 • 180 citations

Effects of anandamide on cannabinoid receptors in rat brain membranes

1994 • 179 citations

Muscarinic acetylcholine receptor‐stimulated binding of guanosine 5′‐O‐(3‐thiotriphosphate) to guanine‐nucleotide‐binding proteins in cardiac membranes

1989 • 170 citations

Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding.

1993 • 154 citations

Endogenous cannabinoids as an aversive or counter-rewarding system in the rat

1997 • 152 citations

Differences in G-protein activation by μ- and δ-opioid, and cannabinoid, receptors in rat striatum

1996 • 145 citations

Paradoxical action of the cannabinoid WIN 55,212‐2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices

1997 • 117 citations

Tubulin-G Protein Association Stabilizes GTP Binding and Activates GTPase: Cytoskeletal Participation in Neuronal Signal Transduction

1994 • 114 citations

Cannabinoid receptor stimulation of guanosine-5′-O-(3-[35S]thio)triphosphate binding in rat brain membranes

1996 • 107 citations

Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.

1987 • 97 citations

Signal amplification in HL‐60 granulocytes

1991 • 88 citations

Role of cyclic amp dependent protein kinase in cannabinoid receptor modulation of potassium “A-current” in cultured rat hippocampal neurons

1995 • 70 citations

Acute and Chronic Effects of Opioids on δ and μ Receptor Activation of G Proteins in NG108‐15 and SK‐N‐SH Cell Membranes

1997 • 64 citations

Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain

1997 • 59 citations

Interaction of full and partial agonists of the A1 adenosine receptor with receptor/G protein complexes in rat brain membranes.

1996 • 53 citations

Catecholamine-stimulated guanosine 5'-O-(3-thiotriphosphate) binding to the stimulatory GTP-binding protein of adenylate cyclase: kinetic analysis in reconstituted phospholipid vesicles

1984 • 43 citations

Dissociation of guanosine 5′‐[γ‐thio]triphosphate from guanine‐nucleotide‐binding regulatory proteins in native cardiac membranes

1992 • 27 citations

Subsecond modulation of formyl peptide-linked guanine nucleotide-binding proteins by guanosine 5'-O-(3-thio)triphosphate in permeabilized neutrophils.

1993 • 19 citations

Testing models of agonism for G protein-coupled receptors

1991 • 17 citations