Signaling Pathway Associated with Stimulation of CB2 Peripheral Cannabinoid Receptor

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Genomic sequencing.

1984 • 8,343 citations

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1994 • 1,743 citations

Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations

1995 • 1,689 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.

1992 • 694 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1991 • 679 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

1995 • 535 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Cannabinoid pharmacology

1987 • 368 citations

Cannabinoid‐receptor expression in human leukocytes

1993 • 361 citations

Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes.

1984 • 353 citations

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

1994 • 326 citations

The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator.

1990 • 256 citations

Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.

1992 • 243 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.

1991 • 231 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

Stimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells

1995 • 173 citations

Cannabinoids enhance human B‐cell growth at low nanomolar concentrations

1995 • 168 citations

5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene

1988 • 158 citations

Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism

1994 • 131 citations

Protein kinase C α, δ, ϵ and ζ in C₆ glioma cells

1993 • 86 citations

Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes.

1995 • 54 citations

Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain

1994 • 54 citations

Induction of the Krox 24 transcription factor in striosomes by a cannabinoid agonist

1995 • 32 citations

Rapid isolation of highly productive recombinant Chinese hamster ovary cell lines

1994 • 31 citations

Evidence for a Cannabinoid Receptor in Immunomodulation by Cannabinoid Compounds

1993 • 11 citations