Stoichiometry of the mixed function oxidase

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Flavins and Flavoproteins

1967 • 599 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Handbook of experimental pharmacology

1971 • 526 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Microsomes and drug oxidation

1969 • 451 citations

The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen.

1957 • 399 citations

Flavins and Flavoproteins

2021 • 391 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states.

1978 • 346 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

Mechanisms of Oxygen Metabolism

1957 • 312 citations

Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes

1966 • 285 citations

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

1969 • 275 citations

Microsomes and Drug Oxidations

1978 • 256 citations

The Structural Basis of Membrane Function

1976 • 253 citations

A new spectral intermediate associated with cytochrome P-450 function in liver microsomes

1971 • 240 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1971 • 223 citations

ON THE MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES

1965 • 218 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1968 • 213 citations

Immunochemical Studies on Electron Transport Chains Involving Cytochrome P-450

1971 • 211 citations

Studies on the Mechanism of Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase

1965 • 201 citations

Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation

1976 • 201 citations

Evidence for superoxide generation by NADPH-cytochrome C reductase of rat liver microsomes

1972 • 193 citations

Redox properties of the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 and reduced nicotinamide adenine dinucleotide-cytochrome b₅ reductases

1974 • 193 citations

Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450

1977 • 187 citations

Biological hydroxylation mechanisms

1973 • 186 citations

Singlet oxygen production associated with enzyme-catalyzed lipid peroxidation in liver microsomes

1975 • 167 citations

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

1978 • 155 citations

Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis.

1976 • 152 citations

One-electron-transfer reactions in biochemical systems III. One-electron reduction of quinones by microsomal flavin enzymes

1969 • 145 citations

Superoxide anion production by the autoxidation of cytochrome P450cam

1974 • 139 citations

A possible mechanism of the generation of singlet molecular oxygen in NADPH-dependent microsomal lipid peroxidation

1976 • 139 citations

The Biosynthesis of Trimethylamine-N-Oxide

1962 • 138 citations

Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes.

1970 • 138 citations

THE REDUCTIVE CLEAVAGE OF 4-DIMETHYLAMINOAZOBENZENE BY RAT LIVER: THE INTRACELLULAR DISTRIBUTION OF THE ENZYME SYSTEM AND ITS REQUIREMENT FOR TRIPHOSPHOPYRIDINE NUCLEOTIDE

1949 • 137 citations

Singlet oxygen in biological systems

1977 • 137 citations

Cytochrome P450cam and its complexes, Mo¨ssbauer parameters of the heme iron

1976 • 133 citations

Spectroscopic evidence for the generation of singlet oxygen in the reduced nicotinamide adenine dinucleotide phosphate-dependent microsomal lipid peroxidation system.

1975 • 133 citations

The Role of NADH in Uncoupled Microsomal Monoxygenations

1974 • 131 citations

THE METABOLISM OF METHYLATED AMINOAZO DYES

1953 • 128 citations

Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450

1976 • 124 citations

The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system.

1957 • 121 citations

Purified liver microsomal cytochrome P-450. Electron-accepting properties and oxidation-reduction potential.

1975 • 120 citations

Die enzymatische Dehydrierung der Stearinsäure zu Ölsäure

1959 • 120 citations

The Involvement of Cytochrome P-450 in Hepatic Microsomal Steroid Hydroxylation Reactions Supported by Sodium Periodate, Sodium Chlorite, and Organic Hydroperoxides

1976 • 115 citations

Microsomal electron transport reactions

1971 • 114 citations

Role of Cytochrome b5 in Hydroxylation by a Reconstituted Cytochrome P-450-containing System

1974 • 112 citations

Inhibition of Lipid Peroxidation in Microsomes by Vitamin E

1960 • 112 citations

Electron transfer interactions between superoxide ion and organic compounds

1973 • 109 citations

Enzymatic reduction of niridazole by rat liver microsomes

1971 • 102 citations

The Mechanism of 1- and 2-Electron Transfers Catalyzed by Reduced Triphosphopyridine Nucleotide-Cytochrome c Reductase

1965 • 102 citations

Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates

1976 • 100 citations

Possible higher valence states of cytochrome P-450 during oxidative reactions

1974 • 96 citations

Mechanism of p-nitrobenzoate reduction in liver: the possible role oc cytochrome P-450 in liver microsomes.

1968 • 94 citations

Microsomal electron transport reactions

1971 • 93 citations

The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450

1977 • 93 citations

On the biosynthesis of dienoic fatty acid by animal tissues

1963 • 92 citations

Studies on three microsomal electron transfer enzyme systems

1977 • 92 citations

Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction

1973 • 90 citations

The Stoichiometry of C21 Hydroxylation of Steroids by Adrenocortical Microsomes

1963 • 89 citations

Studies on the mechanism of action of mammalian hepatic azoreductase—II

1967 • 87 citations

Reduced Pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes

1973 • 86 citations

Purification and properties of cytochrome P-450 obtained from liver microsomes of untreated rats by lauric acid affinity chromatography.

1978 • 81 citations

Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes

1974 • 78 citations

Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes

1974 • 77 citations

Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. I. Effects of activation and inhibition of the fatty acyl coenzyme A desaturation system.

1973 • 74 citations

Irreversible binding of dopa and dopamine metabolites to protein by rat liver microsomes

1975 • 69 citations

The many roles of cytochrome 5 in hepatic microsomes

1976 • 65 citations

Sodium periodate, sodium chlorite, and organic hydroperoxides as hydroxylating agents in steroid hydroxylation reactions catalyzed by adrenocortical microsomal and mitochondrial cytochrome P450

1976 • 62 citations

The microsomal oxygenation of ethyl benzene: Isotopic, stereochemical, and induction studies

1969 • 58 citations

STUDIES ON THE NADPH OXIDASE REACTION OF NADPH‐CYTOCHROME C REDUCTASE. I. THE ROLE OF SUPEROXIDE ANION*

1973 • 57 citations

Evidence that puriified liver microsomal cytochrome P-450 is a one-electron acceptor.

1977 • 57 citations

Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450.

1976 • 56 citations

Enzymic hydroxylation of aromatic compounds

1961 • 55 citations

Studies on the Lipogenesis in Animal Tissues under Pathological Conditions

1961 • 54 citations

The mechanism of the oxidation of d-amphetamine by rabbit liver oxygenase. Oxygen-18 studies

1971 • 52 citations

Different contribution of rat liver microsomal pigments in the formation of superoxide anions and hydrogen peroxide during development

1977 • 52 citations

Evidence for the involvement of cytochrome P-450 in tiaramide N-oxide reduction

1974 • 52 citations

THE EFFECT OF HIGH SALT CONCENTRATIONS UPON CYTOCHROME C, CYTOCHROME B₅, AND IRON‐EDTA REDUCTASE ACTIVITIES OF LIVER MICROSOMAL NADPH‐CYTOCHROME C REDUCTASE*

1973 • 51 citations

The relevance of the superoxide anion radical in biological systems.

1974 • 50 citations

Enzymes and drug action

1963 • 49 citations

Relationship between NADH and NADPH oxidation during drug metabolism.

1973 • 44 citations

Superoxide anion production by liver microsomes from phenobarbital treated rat

1978 • 40 citations

The formation of an azo anion free radical metabolite during the microsomal azo reduction of sulfonazo III

1977 • 38 citations

ORGANIZATION OF THE MICROSOMAL ELECTRON TRANSPORT SYSTEM

1969 • 37 citations

Production of superoxide ions in rat liver microsomes

1973 • 35 citations

Evidence against participation of cytochrome b5 in the hepatic microsomal mixed-function oxidase reaction.

1973 • 35 citations

Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase in drug oxidation.

1971 • 34 citations

Bioreduction of Organic Nitrogen

1971 • 34 citations

Properties of partially purified liver microsomal cytochrome P‐450: Acceptance of two electrons during anaerobic titration

1974 • 32 citations

Influences of substrates of different microsomal electron transfer pathways on the oxidation-reduction kinetics of microsomal cytochrome b5

1978 • 30 citations

Autoxidation of soluble trypsin-cleaved microsomal ferrocytochrome b5 and formation of superoxide radicals

1976 • 28 citations

The redox potential of liver cytochrome P-450

1970 • 27 citations

Effect of 4,4-dideuteration of reduced nicotinamide-adenine dinucleotide phosphate on the mixed function oxidases of hepatic microsomes

1970 • 26 citations

Reduction of tertiary amine N-oxide by purified cytochrome P-450

1977 • 24 citations

Reduction of tertiary amine N-oxides by cytochrome P-450. Mechanism of the stimulatory effect of flavins and methyl viologen.

1978 • 24 citations

Active oxygen in liver microsomes: mechanism of epinephrine oxidation.

1979 • 24 citations

Mono-oxygenase-Linked Hydrogen Peroxide Production and Degradation in Liver Microsomal Fractions

1975 • 23 citations

The effect of extra bound cytochrome b5 on cytochrome P-450-dependent enzyme activities in liver microsomes

1974 • 23 citations

Hepatic microsomal metabolism of epinephrine and adrenochrome by superoxide-dependent and -independent pathways

1979 • 21 citations

Electron transfer in the membranes of endoplasmic reticulum

1975 • 21 citations

Specificity of Naphthoquinones as Cofactor for NADPH Oxidation by Liver Microsomes

1967 • 20 citations

Inhibition by deuterated water of the mixed-function oxidases of hepatic microsomes of the male rat.

1972 • 17 citations

SIGNIFICANCE OF MIXED OXYGENASES AND NITROREDUCTASE IN DRUG METABOLISM

1969 • 16 citations

Interaction of epinephrine metabolites with the liver microsomal electron transport system.

1977 • 15 citations

Discrepancy in the Measurement of Reduced Triphosphopyridine Nucleotide Oxidized during Ethylmorphine N-Demethylation Due to the Presence of a Nucleotide Pyrophosphatase

1974 • 14 citations

Studies on hepatic microsomal N- and O-dealkylation of morphine analogues.

1968 • 13 citations

Kinetic Experiments on the Synergistic Effect of NADH on Microsomal Drug Oxidation

1974 • 13 citations

Studies on the N-demethylation and O-de-ethylation of ethylmorphine by hepatic microsomes from male rats.

1977 • 13 citations

Reductive titration of cytochrome P-450 in rat liver microsomes.

1977 • 11 citations

NADH-synergism of NADPH-dependent O-dealkylation of type II compounds, p-anisidine and p-phenetidine, in rat liver microsomes

1977 • 11 citations

An approach measurement of the stoichiometric relationship between hepatic microsomal drug metabolism and the oxidation of reduced nicotinamide adenine dinucleotide phosphate.

1972 • 11 citations

Structure and reactions of oxygenase active centres: cytochrome P-450 and iron-sulphur proteins

1971 • 10 citations

Pyridine nucleotide involvement in rat hepatic microsomal drug metabolism—II. Evidence for a co-operative interaction between NADPH and NADH

1978 • 10 citations

Respiratory control in submitochondrial particles and Ca++ transport

1967 • 9 citations

Electron transfer in the membranes of endoplasmic reticulum

1975 • 7 citations

Stimulation of NADH oxidation during NADPH dependent microsomal electron transport reactions

1976 • 6 citations

Model Systems in Studies of the Chemistry and the Enzymatic Activation of Oxygen

1971 • 6 citations

Pyridine nucleotide involvement in rat hepatic microsomal drug metabolism—III. The influence of the 1,4,5,6-tetrahydronicotinamide analogue of NADH on the NADPH kinetics of aminopyrine-N-demethylation

1978 • 5 citations

STOICHIOMETRY OF OXYGEN UPTAKE, NADPH OXIDATION AND ETHYLMORPHINE N-DEMETHYLATION BY HEPATIC MICROSOMES

1977 • 2 citations

Mechanism of the cytochrome P-450 catalyzed hydroxylation--thermodynamical aspects and the nature of the active oxygen species.

1978 • 2 citations

Active oxygen in hepatic microsomes

1976 • 1 citations