Production of Radicals from Enzyme Systems and the Use of Spin Traps

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

Carbon Tetrachloride Hepatotoxicity: An Example of Lethal Cleavage

1973 • 729 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

1969 • 697 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used

1971 • 538 citations

Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method.

1975 • 464 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 448 citations

An Electron Spin Resonance Study of the Spin Adducts of OH and HO₂ Radicals with Nitrones in the Ultraviolet Photolysis of Aqueous Hydrogen Peroxide Solutions

1974 • 410 citations

Defective Superoxide Production by Granulocytes from Patients with Chronic Granulomatous Disease

1974 • 375 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

Formation of singlet oxygen by the myeloperoxidase-mediated antimicrobial system.

1977 • 262 citations

Evidence that the superoxide-generating system of human leukocytes is associated with the cell surface.

1977 • 240 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1971 • 223 citations

Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation

1976 • 201 citations

Superoxide formation in spinach chloroplasts: Electron spin resonance detection by spin trapping

1975 • 179 citations

THE EFFECT OF IRON ON THE DISTRIBUTION OF SUPEROXIDE AND HYDROXYL RADICALS AS SEEN BY SPIN TRAPPING AND ON THE SUPEROXIDE DISMUTASE ASSAY

1978 • 179 citations

Spin-trapping studies of hydroxyl radical production involved in lipid peroxidation

1978 • 168 citations

The superoxide anion and singlet molecular oxygen: Their role in the microbicidal activity of the polymorphonuclear leukocyte

1974 • 161 citations

Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane

1978 • 155 citations

On spin trapping hydroxyl and hydroperoxyl radicals

1978 • 153 citations

The detection of linoleic acid radicals in the anaerobic reaction of lipoxygenase

1973 • 149 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1968 • 144 citations

A comparison of the metabolic response to phagocytosis in human granulocytes and monocytes.

1976 • 134 citations

Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: experiments

1965 • 129 citations

ON THE GENERATION OF THE HYDROXYLATION AGENT FROM SUPEROXIDE RADICAL. CAN THE HABER–WEISS REACTION BE THE SOURCE OF OH RADICALS?

1978 • 118 citations

Effect of CCl-4 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions.

1965 • 116 citations

Superoxide Dismutase Activity in Leukocytes

1974 • 116 citations

In vivo spin-trapping of trichloromethyl radicals formed from CCl4

1979 • 106 citations

Biotransformation and hepatotoxicity of halothane

1977 • 89 citations

Electron spin resonance-spin trapping. Detection of superoxide formation during aerobic microsomal reduction of nitro-compounds

1978 • 76 citations

Myeloperoxidase and singlet oxygen: a reappraisal

1978 • 74 citations

Remodeling of Granulocyte Membrane Fatty Acids During Phagocytosis

1974 • 71 citations

Ambiguity associated with use of singlet oxygen trapping agents in myeloperoxidase-catalyzed oxidations

1978 • 70 citations

Correlation between Antimicrobial Activity and Peroxidase Content of Leukocytes

1973 • 66 citations

On the mechanism of carbon tetrachloride hepatotoxicity: Co-incidence of loss of glucose-6-phosphatase activity with peroxidation of microsomal lipid

1965 • 66 citations

SPIN TRAPPING OF FREE RADICALS PRODUCED FROM NITROSOAMINE CARCINOGENS

1978 • 56 citations

α-1,4-Glucosidase Activity in Leucocytes from the Family of Two Brothers Who Lack this Enzyme in Muscle

1966 • 39 citations

Halothane Hepatotoxicity

1977 • 33 citations

Electron Spin Resonance Studies on the Lipoxygenase Reaction by Spin Trapping and Spin Labelling Methods

1977 • 29 citations

Superoxide dismutase in leukocytes

1974 • 27 citations

Inhibitory effects of superoxide dismutases and various other proteins on the nitroblue tetrazolium reduction by phagocytizing guinea pig polymorphonuclear leukocytes

1975 • 23 citations