Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

1997 • 2,009 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma

1988 • 1,022 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

1999 • 611 citations

Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1

1997 • 585 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

Menin, the product of the MEN1 gene, is a nuclear protein

1998 • 426 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

Multiple endocrine neoplasia type 1.

1999 • 357 citations

The Cytogenesis and Pathogenesis of Pituitary Adenomas*

1998 • 350 citations

Smads bind directly to the Jun family of AP-1 transcription factors

1999 • 324 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Transforming Growth Factor-β1 Induces Interleukin-6 Expression via Activating Protein-1 Consisting of JunD Homodimers in Primary Human Lung Fibroblasts

1999 • 182 citations

Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

1999 • 176 citations

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

1999 • 168 citations

Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins

1996 • 162 citations

Molecular Mechanisms of Transforming Growth Factor-β Signaling

1998 • 135 citations

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

1999 • 120 citations

Stable overexpression of MEN1 suppresses tumorigenicity of RAS

1999 • 105 citations

Roles of Pathway-Specific and Inhibitory Smads in Activin Receptor Signaling

1999 • 100 citations

Cell cycle regulation of menin expression.

1999 • 72 citations

Type I Receptors Specify Growth-Inhibitory and Transcriptional Responses to Transforming Growth Factor β and Activin

1994 • 70 citations

Three Activator Protein-1-binding Sites Bound by the Fra-2·JunD Complex Cooperate for the Regulation of Murine Laminin α3A (lama3A) Promoter Activity by Transforming Growth Factor-β

1998 • 45 citations