Prognostic significance of TP53 alterations in breast carcinoma

Regression Models and Life-Tables

1972 • 27,145 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies

1981 • 1,664 citations

Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

1977 • 1,372 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

P53 expression in breast cancer

1988 • 612 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Genetic basis for p53 overexpression in human breast cancer.

1991 • 287 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1990 • 283 citations

Inherited p53 gene mutations in breast cancer.

1992 • 255 citations

p53 mutations in breast cancer.

1992 • 243 citations

Mutations in p53 as potential molecular markers for human breast cancer.

1991 • 222 citations

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.

1991 • 200 citations

Abnormal expression of wild type p53 protein in normal cells of a cancer family patient

1992 • 199 citations

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.

1991 • 192 citations

Screening for germ line TP53 mutations in breast cancer patients.

1992 • 190 citations

p53 expression in human breast cancer related to survival and prognostic factors: An immunohistochemical study

1991 • 183 citations

Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer

1991 • 174 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

p53 mutations occur in aggressive breast cancer.

1992 • 159 citations

Relation between p53 overexpression and established prognostic factors in breast cancer.

1991 • 149 citations

Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.

1993 • 122 citations

p53 gene mRNA expression and chromosome 17p allele loss in breast cancer

1990 • 120 citations

The cellular protein p53 in human tumours.

1984 • 104 citations

Detection of point mutations in the p53 gene: Comparison of single-strand conformation polymorphism, constant denaturant gel electrophoresis, and hydroxylamine and osmium tetroxide techniques

1993 • 99 citations

Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer.

1991 • 92 citations

REPORTS

1991 • 92 citations

Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosis

1990 • 63 citations

Constitutional p53 mutation in a non-Li-Fraumeni cancer family

1992 • 57 citations

Formation of DNA modifications by chemical carcinogens Identification, localization and quantification

1984 • 38 citations

Prognosis and treatment decisions in patients with breast cancer without axillary node involvement

1992 • 33 citations

A new Taql polymorphism in the p53 gene

1992 • 32 citations

Adjuvant therapy in node-negative breast cancer

1989 • 28 citations

No alterations in exon 21 of the RBI gene in sarcomas and carcinomas of the breast, colon, and lung

1992 • 11 citations