p53 expression in human breast cancer related to survival and prognostic factors: An immunohistochemical study

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATION

1974 • 2,413 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Fixation of Ejaculated Spermatozoa for Electron Microscopy

1967 • 1,445 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

1979 • 736 citations

P53 expression in breast cancer

1988 • 612 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

1982 • 448 citations

Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer.

1984 • 385 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1985 • 334 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

ALLELE LOSS ON SHORT ARM OF CHROMOSOME 17 IN BREAST CANCERS

1988 • 236 citations

Human p53 gene localized to short arm of chromosome 17

1986 • 222 citations

Overproduction of p53 antigen makes established cells highly tumorigenic

1985 • 217 citations

The cellular oncogene p53 can be activated by mutagenesis

1985 • 181 citations

The cancer research campaign (King's/Cambridge trial for early breast cancer: Clinico-pathological aspects

1982 • 174 citations

Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma

1987 • 134 citations

p53 gene mRNA expression and chromosome 17p allele loss in breast cancer

1990 • 120 citations

Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles.

1990 • 115 citations

NCL‐CB11, a new monoclonal antibody recognizing the internal domain of the c‐erbB‐2 oncogene protein effective for use on formalin‐fixed, paraffin‐embedded tissue

1990 • 108 citations

Wild type human p53 is antiproliferative in SV40-transformed hamster cells.

1990 • 97 citations

C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis

1990 • 77 citations

Immunohistochemical Assessment of ER-P31, a Mouse Anti-Oestrogen Receptor Protein Monoclonal Antibody in Human Breast Cancers: Comparison with ER-ICA (Abbott) and Radioligand Assays

1991 • 8 citations

The clinical usefulness of oestrogen-receptor and other markers of hormone dependence

1989 • 8 citations