Visualizing synapse formation and remodeling: recent advances in real-time imaging of CNS synapses

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

1997 • 3,163 citations

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

1998 • 2,538 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Fluorescent proteins from nonbioluminescent Anthozoa species

1999 • 1,804 citations

DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

1999 • 1,485 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

1999 • 1,272 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons

2000 • 1,176 citations

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation.

1992 • 1,080 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Dendritic Spines: Cellular Specializations Imparting Both Stability and Flexibility to Synaptic Function

1994 • 970 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

1999 • 964 citations

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

1992 • 940 citations

Rapid Actin-Based Plasticity in Dendritic Spines

1998 • 920 citations

Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody

1994 • 860 citations

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.

1988 • 851 citations

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

1996 • 845 citations

Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation

1996 • 844 citations

Dynamic and quantitative Ca ²⁺ measurements using improved cameleons

1999 • 815 citations

Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo

2000 • 804 citations

Signal-Processing Machines at the Postsynaptic Density

2000 • 792 citations

Long-term potentiation and functional synapse induction in developing hippocampus

1996 • 787 citations

Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures.

1986 • 785 citations

Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular Junction

1992 • 766 citations

Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1

1998 • 756 citations

EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation

2000 • 702 citations

Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation

1998 • 693 citations

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

1999 • 673 citations

Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

1999 • 652 citations

Neuroligin 1: A splice site-specific ligand for β-neurexins

1995 • 635 citations

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

1983 • 617 citations

Assembly of presynaptic active zones from cytoplasmic transport packets

2000 • 602 citations

Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals

1992 • 580 citations

The Use of pHluorins for Optical Measurements of Presynaptic Activity

2000 • 577 citations

VAMP-1: a synaptic vesicle-associated integral membrane protein.

1988 • 574 citations

Persistent protein kinase activity underlying long-term potentiation

1988 • 557 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

PDZ domains in synapse assembly and signalling

2000 • 525 citations

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons

1993 • 523 citations

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

1996 • 500 citations

Spatiotemporal Dynamics of Inositol 1,4,5-Trisphosphate That Underlies Complex Ca ²⁺ Mobilization Patterns

1999 • 500 citations

Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses

1999 • 496 citations

Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

1997 • 493 citations

Assembly of New Individual Excitatory Synapses

2000 • 490 citations

Bassoon, a Novel Zinc-finger CAG/Glutamine-repeat Protein Selectively Localized at the Active Zone of Presynaptic Nerve Terminals

1998 • 478 citations

The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture

1991 • 463 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism.

1995 • 451 citations

Glutamate receptors regulate actin-based plasticity in dendritic spines

2000 • 446 citations

Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system

2000 • 417 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

A Model for Central Synaptic Junctional Complex Formation Based on the Differential Adhesive Specificities of the Cadherins

1996 • 411 citations

Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons

1999 • 399 citations

Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture

1998 • 396 citations

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

1984 • 389 citations

Enlightening the Postsynaptic Density

1997 • 381 citations

Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses

2000 • 376 citations

Synaptic Vesicles and Exocytosis

1994 • 371 citations

The distribution of glutamate receptors in cultured rat hippocampal neurons: Postsynaptic clustering of AMPA selective subunits

1993 • 340 citations

Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons

1992 • 336 citations

Potentiated Transmission and Prevention of Further LTP by Increased CaMKII activity in Postsynaptic Hippocampal Slice Neurons

1994 • 330 citations

Synaptic Targeting of the Postsynaptic Density Protein PSD-95 Mediated by Lipid and Protein Motifs

1999 • 327 citations

PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses

1996 • 312 citations

Molecular Modification of N-Cadherin in Response to Synaptic Activity

2000 • 306 citations

Synaptic vesicle dynamics in living cultured hippocampal neurons visualized with CY3-conjugated antibodies directed against the lumenal domain of synaptotagmin

1995 • 294 citations

Two-photon scanning photochemical microscopy: mapping ligand-gated ion channel distributions.

1994 • 293 citations

Vesicle pool mobilization during action potential firing at hippocampal synapses

1995 • 289 citations

Visualization of neuromuscular junctions over periods of several months in living mice

1987 • 270 citations

Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses.

1996 • 265 citations

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

2000 • 261 citations

A MOLECULAR DESCRIPTION OF SYNAPTIC VESICLE MEMBRANE TRAFFICKING

1994 • 248 citations

Continual remodeling of postsynaptic density and its regulation by synaptic activity

1999 • 244 citations

Maturation of rat visual cortex. II. A combined Golgi‐electron microscope study of pyramidal neurons

1981 • 235 citations

ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN

1974 • 235 citations

In vivo visualization of the growth of pre- and postsynaptic elements of neuromuscular junctions in the mouse

1990 • 229 citations

Molecular determinants of presynaptic active zones

2000 • 213 citations

Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II

2000 • 205 citations

Analysis of microspike movements on the neuronal growth cone

1985 • 205 citations

The structure of postsynaptic densities isolated from dog cerebral cortex: II. characterization and arrangement of some of the major proteins within the structure

1977 • 204 citations

The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain

1999 • 195 citations

Presynaptic Component of Long-Term Potentiation Visualized at Individual Hippocampal Synapses

1995 • 192 citations

Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein

1999 • 184 citations

Imaging Synaptic Activity in Intact Brain and Slices with FM1-43 in C. elegans, Lamprey, and Rat

1999 • 172 citations

Comparison of Hippocampal Dendritic Spines in Culture and in Brain

1998 • 142 citations

Postnatal ontogenesis of hippocampal CA1 area in rats. II. Development of ultrastructure in stratum lacunosum and moleculare

1981 • 125 citations

Morphology and molecular composition of isolated postsynaptic junctional structures

1978 • 122 citations

Expression patterns of GABAA receptor subtypes in developing hippocampal neurons

1991 • 118 citations

Molecular Determinants for Subcellular Localization of PSD-95 with an Interacting K+ Channel

1999 • 115 citations

Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part I: Trans-Golgi Network-Derived Organelles Undergo Regulated Exocytosis

1998 • 111 citations

Ultrastructural changes in synapses in the dentate gyrus of the rat during development

1973 • 106 citations

N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons.

1993 • 93 citations

Distinct Roles for Ionotropic and Metabotropic Glutamate Receptors in the Maturation of Excitatory Synapses

2000 • 91 citations

Development of rabbit hippocampus: Anatomy

1981 • 81 citations

Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part II: Mediation by Calcium/Calmodulin-Dependent Protein Kinase II

1998 • 80 citations

Visualization of Synaptic Activity in Hippocampal Slices with FM1-43 Enabled by Fluorescence Quenching

1999 • 79 citations

Protein kinase Cα targeting is regulated by temporal and spatial changes in intracellular free calcium concentration [Ca²⁺]_i

2000 • 74 citations

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

2000 • 72 citations

Fine structure of neurons and synapses in the feline hippocampus during postnatal ontogenesis

1968 • 63 citations

Protein kinase Calpha targeting is regulated by temporal and spatial changes in intracellular free calcium concentration [Ca2+]i

2000 • 35 citations

Accumulation of Acetylcholine Receptors at Nerve-Muscle Contacts in Culture

1979 • 32 citations

Formation of acetylcholine receptor clusters at neuromuscular junction in Xenopus cultures

1985 • 28 citations

Deleted Work

1955 • 0 citations