Potentiated Transmission and Prevention of Further LTP by Increased CaMKII activity in Postsynaptic Hippocampal Slice Neurons

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 • 803 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents

1978 • 665 citations

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

1983 • 617 citations

Persistent protein kinase activity underlying long-term potentiation

1988 • 557 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses

1991 • 487 citations

Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs

1993 • 437 citations

Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II

1993 • 437 citations

Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.

1993 • 402 citations

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

1984 • 389 citations

The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation

1993 • 342 citations

Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation

1987 • 340 citations

Long‐term synaptic enhancement and short‐term potentiation in rat fascia dentata act through different mechanisms

1982 • 331 citations

Reduction of long‐term potentiation in the dentate gyrus of the rat following selective depletion of monoamines.

1983 • 290 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes

1990 • 284 citations

Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.

1988 • 261 citations

Putative Single Quantum and Single Fibre Excitatory Postsynaptic Currents Show Similar Amplitude Range and Variability in Rat Hippocampal Slices

1992 • 257 citations

Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CAl pyramidal cell dendrites

1990 • 234 citations

Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells

1986 • 233 citations

Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors.

1993 • 226 citations

Identification of the Major Postsynaptic Density Protein as Homologous with the Major Calmodulin‐Binding Subunit of a Calmodulin‐Dependent Protein Kinase

1984 • 220 citations

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1991 • 192 citations

Protein kinase C phosphorylates a 47 Mr protein (F1) directly related to synaptic plasticity

1985 • 186 citations

Synaptic efficacy and EPSP summation in granule cells of rat fascia dentata studied in vitro.

1981 • 180 citations

Polymyxin B, an inhibitor of protein kinase C, prevents the maintenance of synaptic long-term potentiation in hippocampal CA1 neurons

1988 • 178 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown.

1990 • 173 citations

Protein-synthetic machinery beneath postsynaptic sites on CNS neurons: association between polyribosomes and other organelles at the synaptic site

1988 • 144 citations

The role of Ca2+ entry via synaptically activated NMDA receptors in the induction of long-term potentiation

1993 • 140 citations

Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.

1991 • 120 citations

Selective localization of polyribosomes beneath developing synapses: A quantitative analysis of the relationships between polyribosomes and developing synapses in the hippocampus and dentate gyrus

1991 • 114 citations

Brain Slices

1984 • 98 citations

Visualizing hippocampal synaptic function by optical detection of Ca2+ entry through the N-methyl-D-aspartate channel.

1994 • 93 citations

Rapid activation of hippocampal casein kinase II during long-term potentiation.

1991 • 86 citations

Polyribosomes at the Base of Dendritic Spines of Central Nervous System Neurons--Their Possible Role in Synapse Construction and Modification

1983 • 80 citations

Specific involvement of Ca(2+)-calmodulin kinase II in cholinergic modulation of neuronal responsiveness

1992 • 78 citations

Phorbol ester-induced synaptic potentiation differs from long-term potentiation in the guinea pig hippocampus in vitro

1988 • 75 citations

Phorbol ester-induced synaptic facilitation is different than long-term potentiation.

1988 • 72 citations

Polyribosomes associated with synaptic specializations on axon initial segments: localization of protein-synthetic machinery at inhibitory synapses

1986 • 64 citations

Rabbit ileal villus cell brush border Na+/H+ exchange is regulated by Ca2+/calmodulin-dependent protein kinase II, a brush border membrane protein.

1990 • 58 citations

Calcium-induced long-term potentiation in the hippocampal slice: Characterization of the time course and conditions

1986 • 49 citations

Active catalytic fragment of Ca2+/calmodulin-dependent protein kinase II. Purification, characterization, and structural analysis

1991 • 44 citations

Aniracetam‐evoked potentiation does not interact with long‐term potentiation in the CA1 region of the hippocampus

1992 • 18 citations