When X-ray-inducible proteins meet DNA double strand break repair

The double-strand-break repair model for recombination

1983 • 2,468 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1992 • 1,231 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae

1996 • 733 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

1996 • 593 citations

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

1998 • 576 citations

Partners and pathways

2000 • 563 citations

Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

1997 • 551 citations

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

1998 • 550 citations

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

1997 • 536 citations

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1999 • 533 citations

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

1998 • 530 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Stimulation by Rad52 of yeast Rad51- mediated recombination

1998 • 459 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

DNA strand annealing is promoted by the yeast Rad52 protein.

1996 • 455 citations

Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA.

1994 • 452 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

1999 • 438 citations

Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.

1989 • 412 citations

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

1998 • 410 citations

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

1990 • 403 citations

The Many Interfaces of Mre11

1998 • 401 citations

Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid.

1983 • 399 citations

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

2001 • 392 citations

Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae

1997 • 371 citations

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

1998 • 367 citations

Clusterin is a secreted mammalian chaperone

2000 • 365 citations

5 DNA Breakage and Repair

1998 • 363 citations

Role of RecA protein spiral filaments in genetic recombination

1984 • 362 citations

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

1998 • 361 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

1988 • 361 citations

The Fanconi anaemia group G gene FANCG is identical with XRCC9

1998 • 347 citations

Apolipoprotein J: structure and tissue distribution

1990 • 339 citations

MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks

1999 • 332 citations

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

1997 • 330 citations

Ku is associated with the telomere in mammals

1999 • 321 citations

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

1998 • 314 citations

Binding of double-strand breaks in DNA by human Rad52 protein

1999 • 314 citations

Ku complex interacts with and stimulates the Werner protein

2000 • 308 citations

The integrase family of tyrosine recombinases: evolution of a conserved active site domain

1997 • 308 citations

Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways.

1996 • 307 citations

Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins.

1995 • 297 citations

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells

1998 • 286 citations

Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

2000 • 279 citations

Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae

1996 • 275 citations

Ku, a DNA repair protein with multiple cellular functions?

1999 • 273 citations

DNA Length Dependence of the Single-Strand Annealing Pathway and the Role of Saccharomyces cerevisiae RAD59 in Double-Strand Break Repair

2000 • 270 citations

Active cell death in hormone-dependent tissues

1992 • 264 citations

Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate

1987 • 256 citations

Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription

1997 • 248 citations

Apolipoprotein J (clusterin) and Alzheimer's disease

2000 • 243 citations

Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.

1989 • 243 citations

Overexpression of Clusterin in Human Breast Carcinoma

2000 • 242 citations

Ram Rete Testis Fluid Contains a Protein (Clusterin) Which Influences Cell-Cell Interactions in Vitro 1

1983 • 242 citations

The Mre11 complex and ATM: collaborating to navigate S phase

2000 • 234 citations

Homologous recombination and the roles of double-strand breaks

1995 • 234 citations

Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase

2000 • 230 citations

Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52.

1993 • 228 citations

Functional Differences and Interactions among the Putative RecA Homologs Rad51, Rad55, and Rad57

1995 • 228 citations

Inactivation of p53 results in high rates of homologous recombination

1997 • 225 citations

Identification of Glycoprotein 330 as an Endocytic Receptor for Apolipoprotein J/Clusterin

1995 • 220 citations

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

1999 • 218 citations

Regulation of Rad51 Function by c-Abl in Response to DNA Damage

1998 • 217 citations

The partial tandem duplication of ALL1 ( MLL ) is consistently generated by Alu- mediated homologous recombination in acute myeloid leukemia

1998 • 216 citations

Interaction of p53 with the Human Rad51 Protein

1997 • 212 citations

Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer

2000 • 211 citations

DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

2000 • 209 citations

Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models.

2000 • 202 citations

RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage

1997 • 198 citations

Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer.

1997 • 195 citations

Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths

1999 • 195 citations

Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

1993 • 194 citations

Apoptosis in Toremifene-Induced Growth Inhibition of Human Breast Cancer Cells In Vivo and In Vitro

1993 • 192 citations

In vivo biochemistry: Physical monitoring of recombination induced by site‐specific endonucleases

1995 • 191 citations

The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination

1996 • 189 citations

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase

1998 • 188 citations

Rad54 Protein Is Targeted to Pairing Loci by the Rad51 Nucleoprotein Filament

2000 • 184 citations

Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis

1989 • 183 citations

Clusterin Gene Expression Mediates Resistance to Apoptotic Cell Death Induced by Heat Shock and Oxidative Stress

1999 • 181 citations

Interaction of human Ku70 with TRF2

2000 • 181 citations

Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9.

1993 • 177 citations

DNA-PK: at the cross-roads of biochemistry and genetics

1997 • 169 citations

Identification and characterization of X-ray-induced proteins in human cells.

1989 • 166 citations

Characterization of the human and mouse WRN 3'->5' exonuclease

2000 • 155 citations

Clusterin (Apolipoprotein J) Protein Levels Are Increased in Hippocampus and in Frontal Cortex in Alzheimer's Disease

1998 • 154 citations

RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

1998 • 153 citations

Protection of Telomeres by the Ku Protein in Fission Yeast

2000 • 151 citations

Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation.

1998 • 150 citations

The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A

1997 • 142 citations

Transforming Growth Factor β (TGFβ)-Induced Nuclear Localization of Apolipoprotein J/Clusterin in Epithelial Cells

1996 • 142 citations

Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier

1996 • 140 citations

Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells.

1993 • 136 citations

Unequal homologous recombination between LINE-1 elements as a mutational mechanism in human genetic disease 1 1Edited by J. Karn

1998 • 136 citations

Human seminal clusterin (SP-40,40). Isolation and characterization.

1990 • 135 citations

Purification and characterization of apolipoprotein J.

1990 • 134 citations

The contribution of homologous recombination in preserving genome integrity in mammalian cells

1999 • 132 citations

Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?

1998 • 119 citations

Pie1, a Protein Interacting with Mec1, Controls Cell Growth and Checkpoint Responses in Saccharomyces cerevisiae

2001 • 117 citations

SP-40,40 is an inhibitor of C5b-6-initiated haemolysis

1989 • 115 citations

Evidence that mammalian cells possess homologous recombinational repair pathways

1996 • 110 citations

Clusterin Biogenesis Is Altered during Apoptosis in the Regressing Rat Ventral Prostate

1998 • 110 citations

Tamoxifen induces TGF-beta 1 activity and apoptosis of human MCF-7 breast cancer cells in vitro.

1996 • 110 citations

Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination

1994 • 107 citations

DNA Double-strand Breaks: Their Repair and Relationship to Cell Killing in Yeast

1990 • 104 citations

Isolation of Ku70-binding proteins (KUBs)

1999 • 102 citations

Double‐strand break repair mediated by DNA end‐joining

1998 • 99 citations

Human Rad52 protein promotes single-strand DNA annealing followed by branch migration

1997 • 98 citations

Rejoining of DNA double‐strand breaks in vitro by single‐strand annealing

1998 • 94 citations

Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas

2000 • 92 citations

Functional and structural properties of lipid-associated apolipoprotein J (clusterin)

1999 • 90 citations

Recombination: a frank view of exchanges and vice versa

2000 • 88 citations

Mechanisms of DNA repair and their potential modification for radiotherapy

1986 • 87 citations

DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System

2000 • 85 citations

Isolation and Immunological Characterization of a Glycoprotein from Adrenal Chromaffin Granules

1984 • 83 citations

Gene conversion tracts stimulated by HOT1-promoted transcription are long and continuous.

1990 • 82 citations

Induction of gene expression during involution of the lactating mammary gland of the rat

1994 • 80 citations

Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis.

1994 • 80 citations

Human Ku70 Interacts with Heterochromatin Protein 1α

2001 • 78 citations

Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations

1999 • 78 citations

Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region

2000 • 77 citations

Possible functions of a new genetic marker in central nervous system: The sulfated glycoprotein‐2 (SGP‐2)

1992 • 77 citations

Expression of clusterin in human renal diseases

1994 • 77 citations

Tamoxifen induces TGF-β1 activity and apoptosis of human MCF-7 breast cancer cells in vitro

1996 • 77 citations

The end-joining reaction in V(D)J recombination

1997 • 76 citations

Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells.

1995 • 75 citations

Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas

1994 • 73 citations

Regulation by ionizing radiation of CDC2, cyclin A, cyclin B, thymidine kinase, topoisomerase IIalpha, and RAD51 expression in normal human diploid fibroblasts is dependent on p53/p21Waf1.

1998 • 73 citations

Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation

1996 • 73 citations

The signal model: a possible explanation for the conversion of DNA double-strand breaks into chromatid breaks

1998 • 71 citations

Sir-Ku-itous Routes to Make Ends Meet

1999 • 70 citations

Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis.

1991 • 70 citations

Checkpoint Proteins Influence Telomeric Silencing and Length Maintenance in Budding Yeast

2000 • 69 citations

Analysis of differentially expressed genes in retinitis pigmentosa retinas Altered expression of clusterin mRNA

1992 • 68 citations

Molecular cloning of gp 80, a glycoprotein complex secreted by kidney cells in vitro and in vivo. A link to the reproductive system and to the complement cascade

1991 • 66 citations

A Novel Human Rad54 Homologue, Rad54B, Associates with Rad51

2000 • 66 citations

Interaction of Transforming Growth Factor β Receptors with Apolipoprotein J/Clusterin

1996 • 64 citations

The DDE Motif in RAG-1 Is Contributed in trans to a Single Active Site That Catalyzes the Nicking and Transesterification Steps of V(D)J Recombination

2001 • 61 citations

Functions of the DNA dependent protein kinase.

1997 • 59 citations

Mitotic activity, apoptosis and TRPM‐2 mRNA expression in dmba‐induced rat mammary carcinoma treated with anti‐estrogen toremifene

1993 • 58 citations

Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase

1999 • 53 citations

Clusterin accumulates in dying neurons following status epilepticus

1995 • 53 citations

The role of clusterin in tissue injury

1994 • 53 citations

Reparability of DNA Double-strand Breaks and Radiation Sensitivity in Five Mammalian Cell Lines

1991 • 51 citations

Expression of clusterin in cell differentiation and cell death

1994 • 51 citations

A Double-Strand Break within a Yeast Artificial Chromosome (YAC) Containing Human DNA Can Result in YAC Loss, Deletion, or Cell Lethality

1996 • 51 citations

Hepatic apolipoprotein J is secreted as a lipoprotein.

1992 • 50 citations

Expression of clusterin (testosterone-repressed prostate message-2) mRNA during growth and regeneration of rat liver

1995 • 48 citations

Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein.

1999 • 47 citations

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

1998 • 45 citations

Increased expression of human DNA repair genes, XRCC1, XRCC3 and RAD51, in radioresistant human KB carcinoma cell line N10

1998 • 45 citations

Clusterin/ApoJ expression during the development of hemangioma

2000 • 45 citations

Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration

1995 • 45 citations

Werner syndrome protein: biochemical properties and functional interactions

2000 • 40 citations

Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa

1994 • 39 citations

Estrogenic regulation of clusterin mRNA in normal and malignant endometrial tissue

1998 • 38 citations

Clusterin Protects Granulosa Cells from Apoptotic Cell Death during Follicular Atresia

2000 • 37 citations

The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non‐homologous end joining

2000 • 37 citations

Differential expression of clusterin in inducible models of apoptosis

1992 • 34 citations

Induction of clusterin in acute and chronic oxidative renal disease in the rat and its dissociation from cell injury.

1994 • 30 citations

Immediate X-Ray-Inducible Responses from Mammalian Cells

1994 • 30 citations

Expression of Apolipoprotein J in the Uterus is Associated with Tissue Remodeling1

1995 • 27 citations

Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: excision of dimers in cell extracts

1981 • 24 citations

EPISTATIC INTERACTIONS OF RADIATION-SENSITIVE (rad) MUTANTS OF CAENORHABDITIS ELEGANS

1985 • 23 citations

Clusterin (Apo J) regulates vascular smooth muscle cell differentiation in vitro

1999 • 22 citations

Temporally and spatially restricted expression of apolipoprotein J in the developing heart defines discrete stages of valve morphogenesis

1994 • 21 citations

Role of clusterin in cell adhesion during early phases of programmed cell death in P19 embryonic carcinoma cells

1996 • 21 citations

Differential Expression of Clusterin in the Testis and Epididymis of Postnatal and Germ Cell Deficient Mice

1996 • 21 citations

TRPM‐2 gene expression in normal rat ventral prostate following castration and exposure to diethylstilbestrol, flutamide, MK‐906 (finasteride), and coumarin

1994 • 21 citations

Isolation of camptothecin-sensitive Chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group

2000 • 19 citations

Expression of TRPM-2 during involution and regeneration of the rat liver

1993 • 18 citations

Lack of Causal Relationship Between Clusterin Expression and Photoreceptor Apoptosis in Light‐Induced Retinal Degeneration

1999 • 16 citations

Expression of clusterin and C4 mRNA during rat peripheral nerve regeneration

1997 • 15 citations

In vitro models of prostate apoptosis: Clusterin as an antiapoptotic mediator

2000 • 15 citations

Identification of clusterin sequences mediating renal tubular cell interactions

1999 • 14 citations

Rad-2-dependent repair of radiation-induced chromosomal aberrations in Caenorhabditis elegans

1989 • 13 citations

DNA Integration by Ty Integrase in yku70Mutant Saccharomyces cerevisiae Cells

2000 • 11 citations

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes

1996 • 10 citations

Expression of a cell death marker (clusterin) in muscle target fibers

1993 • 8 citations