Clusterin Gene Expression Mediates Resistance to Apoptotic Cell Death Induced by Heat Shock and Oxidative Stress

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

1991 • 982 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins.

1986 • 442 citations

Clusterin: Physiologic and pathophysiologic considerations

1995 • 421 citations

Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.

1989 • 412 citations

Clusterin: the intriguing guises of a widely expressed glycoprotein

1992 • 353 citations

Identification of a distinct human high‐density lipoprotein subspecies defined by a lipoprotein‐associated protein, K‐45

1993 • 350 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

1990 • 334 citations

Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.

1981 • 281 citations

Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma

1991 • 260 citations

Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin).

1995 • 224 citations

Stress-induced transcription of the clusterin/apoJ gene

1997 • 196 citations

Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

1993 • 194 citations

Identification of Newly Transcribed <scp>RNA</scp>

2007 • 192 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Apolipoprotein J Is Associated with Paraoxonase in Human Plasma

1994 • 186 citations

Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9.

1993 • 177 citations

Chaperones: Helpers Along the Pathways to Protein Folding

1993 • 174 citations

Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death.

1994 • 170 citations

Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes

1992 • 169 citations

Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney.

1991 • 161 citations

A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein.

1992 • 148 citations

Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas.

1987 • 136 citations

Purification and characterization of apolipoprotein J.

1990 • 134 citations

Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange

1992 • 132 citations

Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis

1993 • 127 citations

Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties

1998 • 102 citations

Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells

1993 • 99 citations

Lack of correspondence between mRNA expression for a putative cell death molecule (SGP‐2) and neuronal cell death in the central nervous system

1991 • 99 citations

Differential gene expression in the recovery from ischemic renal injury

1991 • 97 citations

The biochemical mechanisms of the excitotoxicity of Kainic acid

1992 • 95 citations

Intracellular processing of apolipoprotein J precursor to the mature heterodimer.

1991 • 93 citations

Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter

1998 • 92 citations

Gene expression in response to acute unilateral ureteral obstruction

1989 • 86 citations

Effects of Clusterin Overexpression on TNFα- and TGFβ-Mediated Death of L929 Cells

1997 • 81 citations

Characterization of the Products of a Gene Expressed During Androgen-Programmed Cell Death and their Potential use as a Marker of Urogenital Injury

1990 • 73 citations

Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus.

1992 • 71 citations

Identification and characterization of a novel yeast gene: the YGP1 gene product is a highly glycosylated secreted protein that is synthesized in response to nutrient limitation.

1994 • 70 citations

Diverse Secretory Patterns of Clusterin by Epididymis and Prostate/Seminal Vesicles Undergoing Cell Regression after Orchiectomy*

1990 • 67 citations

SGP-2 expression as a genetic marker of progressive cellular pathology in experimental hydronephrosis

1991 • 67 citations

Increased synthesis of DnaK, GroEL, and GroES homologs by Francisella tularensis LVS in response to heat and hydrogen peroxide

1994 • 67 citations

Dual regulation by heat and nutrient stress of the yeast HSP150 gene encoding a secretory glycoprotein

1993 • 57 citations

Constitutive HSP70: Oligomerization and its dependence on ATP binding

1992 • 42 citations

Heat‐shock response in cultured chick embryo chondrocytes

1992 • 42 citations

Differential expression of clusterin in inducible models of apoptosis

1992 • 34 citations