MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

1975 • 984 citations

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

1998 • 773 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae

1996 • 733 citations

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

1998 • 733 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

1997 • 673 citations

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

1998 • 636 citations

Spreading of transcriptional represser SIR3 from telomeric heterochromatin

1996 • 523 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.

1996 • 447 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

Yeast Ku as a Regulator of Chromosomal DNA End Structure

1998 • 432 citations

Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae

1997 • 371 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

The Schizosaccharomyces pombe rad3 checkpoint gene.

1996 • 366 citations

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

1998 • 345 citations

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

1997 • 330 citations

Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae

1996 • 275 citations

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

1998 • 274 citations

Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression.

1996 • 270 citations

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

1997 • 257 citations

Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination

1995 • 254 citations

DNA Damage and Checkpoint Pathways

1998 • 251 citations

An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae

1994 • 215 citations

Molecular model for telomeric heterochromatin in yeast

1997 • 215 citations

MEC1-Dependent Phosphorylation of Rad9p in Response to DNA Damage

1998 • 213 citations

Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks

1997 • 202 citations

The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination

1996 • 189 citations

Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein.

1996 • 163 citations

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1998 • 160 citations

Distribution of a Limited Sir2 Protein Pool Regulates the Strength of Yeast rDNA Silencing and Is Modulated by Sir4p

1998 • 160 citations

Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

1990 • 152 citations

Mutations in the RNA Polymerase II Transcription Machinery Suppress the Hyperrecombination Mutant hpr1 Δ of Saccharomyces cerevisiae

1996 • 147 citations

DNA Ligase IV from HeLa Cell Nuclei

1996 • 125 citations

On the Role of DNA Double-Strand Breaks in Toxicity and Carcinogenesis

1997 • 111 citations

Fibroblasts from Ataxia Telangiectasia (AT) and AT Heterozygotes Show an Enhanced Level of Residual DNA Double-strand Breaks after Low Dose-rate γ-irradiation as Assayed by Pulsed Field Gel Electrophoresis

1991 • 106 citations

Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae.

1987 • 105 citations

The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia.

1992 • 105 citations

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae

1997 • 99 citations

a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects.

1993 • 88 citations

The Contribution of DNA and Chromosome Repair Deficiencies to the Radiosensitivity of Ataxia-Telangiectasia

1992 • 83 citations

Ataxia-telangiectasia and the ATM gene: Linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

1996 • 80 citations

Regulated expression of endonuclease EcoRI in Saccharomyces cerevisiae: nuclear entry and biological consequences.

1985 • 78 citations

Monofunctional alkylating agent-induced S-phase-dependent DNA damage

1989 • 70 citations

Requirement for End-Joining and Checkpoint Functions, but NotRAD52-Mediated Recombination, after EcoRI Endonuclease Cleavage of Saccharomyces cerevisiaeDNA

1998 • 69 citations

Genetic and Cellular Features of Ataxia Telangiectasia

1994 • 66 citations

Involvement of the Saccharomyces cerevisiae HDF1 Gene in DNA Double-strand Break Repair and Recombination

1996 • 65 citations

The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae

1997 • 59 citations

Recombination and joining: different means to the same ends

1997 • 56 citations

The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks

1998 • 46 citations

DNA Strand Scission by Activated Bleomycin Group Antibiotics

1987 • 40 citations

Silent chromatin in yeast: an orchestrated medley featuring Sir3p

1998 • 39 citations

Inducible DNA-repair systems in yeast: Competition for lesions

1987 • 37 citations

Ho Endonuclease Cleaves MAT DNA in Vitro by an Inefficient Stoichiometric Reaction Mechanism

1997 • 33 citations

Heterogeneity in chromosome damage and repair rates after bleomycin in ataxia telangiectasia cells.

1988 • 28 citations

Sensitivity of fibroblasts derived from ataxia-telangiectasia patients to calicheamicin γ1I

1990 • 22 citations

Genomic Structure and Chromosomal Assignment of the Mouse Ku70 Gene

1996 • 11 citations