Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting

Genomic sequencing.

1984 • 8,343 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

Active demethylation of the paternal genome in the mouse zygote

2000 • 964 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

2000 • 439 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

An enhancer deletion affects both H19 and Igf2 expression.

1995 • 398 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

1997 • 341 citations

The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo

1991 • 312 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes

1994 • 277 citations

Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function

2000 • 255 citations

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2

1997 • 248 citations

Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis

1990 • 228 citations

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

2000 • 203 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Identification of a Methylation Imprint Mark within the Mouse Gnas Locus

2000 • 187 citations

Imprinting mechanisms in mammals

1998 • 173 citations

Differential expression of the human insulin-like growth factor II gene Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein

1988 • 146 citations

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19

2000 • 139 citations

Bisulfite Sequencing in Preimplantation Embryos: DNA Methylation Profile of the Upstream Region of the Mouse ImprintedH19Gene

1998 • 113 citations

Two regulatory domains flank the mouse H19 gene.

1988 • 110 citations

Loss of the maternal H19 gene induces changes in Igf 2 methylation in both cis and trans

1997 • 105 citations

Igf2 imprinting does not require its own DNA methylation or H19 RNA

1998 • 101 citations

Dynamics of DNA methylation pattern

2000 • 99 citations

Igf2 imprinting in development and disease

2000 • 99 citations

Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch

2000 • 95 citations

Dynamic methylation adjustment and counting as part of imprinting mechanisms.

1996 • 81 citations

A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene

2000 • 54 citations

Specific endonucleolytic cleavage of IGF-II mRNAs

1991 • 52 citations

H19 gene expression is up-regulated exclusively by stabilization of the RNA during muscle cell differentiation

2000 • 49 citations