Poly-ADP-ribosylation in health and disease

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

2012 • 8,436 citations

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

2013 • 6,963 citations

2016 European Guidelines on cardiovascular disease prevention in clinical practice

2016 • 5,859 citations

Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project

2003 • 5,083 citations

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

2015 • 3,817 citations

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

2011 • 3,453 citations

Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000

2007 • 2,655 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

2012 • 2,501 citations

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

2009 • 2,461 citations

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

2013 • 2,409 citations

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

2015 • 2,120 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 1,753 citations

Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis

2003 • 1,718 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

Lipoprotein(a) as a cardiovascular risk factor: current status

2010 • 1,599 citations

2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

2016 • 1,521 citations

Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events

2015 • 1,405 citations

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

2015 • 1,303 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Triglycerides and cardiovascular disease

2014 • 1,161 citations

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

1999 • 713 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

2002 • 674 citations

Inhibition of Intestinal Cholesterol Absorption by Ezetimibe in Humans

2002 • 664 citations

Update on Adipocyte Hormones

2004 • 633 citations

Very Low Levels of Atherogenic Lipoproteins and the Risk for Cardiovascular Events

2014 • 540 citations

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

2000 • 532 citations

PARP Goes Transcription

2003 • 530 citations

Cardiovascular disease in Europe — epidemiological update 2015

2015 • 526 citations

Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

1980 • 488 citations

Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population

2013 • 485 citations

Effect of Statins on Skeletal Muscle Function

2012 • 451 citations

Lipoprotein(a): resurrected by genetics

2012 • 445 citations

Chromatin Loosening by Poly(ADP)-Ribose Polymerase (PARP) at Drosophila Puff Loci

2003 • 437 citations

Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis

1999 • 431 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction

2012 • 413 citations

Tankyrase promotes telomere elongation in human cells

2000 • 398 citations

Methods and algorithms for statistical analysis of protein sequences.

1992 • 390 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

PARP-1, a determinant of cell survival in response to DNA damage

2003 • 376 citations

Anti-PCSK9 Monotherapy for Hypercholesterolemia

2014 • 375 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

A systematic review and meta-analysis on the therapeutic equivalence of statins

2009 • 327 citations

Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism

2001 • 316 citations

Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement

2011 • 294 citations

A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation

1999 • 289 citations

Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles

2000 • 273 citations

Resolution of Sister Telomere Association Is Required for Progression Through Mitosis

2004 • 271 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

2001 • 215 citations

ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites.

1980 • 213 citations

Purification and Properties of a Glycohydrolase from Calf Thymus Splitting Ribose-Ribose Linkages of Poly(Adenosine Diphosphate Ribose)

1974 • 205 citations

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

1997 • 204 citations

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

2001 • 203 citations

Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments

2004 • 201 citations

Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes

1999 • 201 citations

Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei.

1981 • 198 citations

Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation.

1986 • 197 citations

Poly(ADP-ribose) Polymerase-1 in the Nervous System

2000 • 196 citations

Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster

2003 • 189 citations

Poly(ADP-ribosyl)ated chromatin domains: access granted

2004 • 189 citations

ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site.

1980 • 185 citations

Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2

2004 • 181 citations

DNA repair: PARP – another guardian angel?

1998 • 173 citations

Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells.

1990 • 170 citations

Dual Function for Poly(ADP-ribose) Synthesis in Response to DNA Strand Breakage

1994 • 168 citations

European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk

2016 • 159 citations

PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression

2003 • 157 citations

Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose).

1986 • 155 citations

Studies on the ADP-ribose Pyrophosphatase Subfamily of the Nudix Hydrolases and Tentative Identification of trgB, a Gene Associated with Tellurite Resistance

1999 • 149 citations

Splitting of the Ribose-Ribose Linkage of Poly(Adenosine Diphosphate-Ribose) by a Calf Thymus Extract

1971 • 148 citations

Involvement of Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribosyl)ation in Regulation of Centrosome Function

2003 • 141 citations

ATP for the DNA Ligation Step in Base Excision Repair Is Generated from Poly(ADP-ribose)

2000 • 140 citations

DNA repair-associated ADP-ribosylation in vivo. Modification of histone H1 differs from that of the principal acceptor proteins.

1984 • 138 citations

Poly ADP-ribose glycohydrolase from rat liver nuclei, a novel enzyme degrading the polymer

1972 • 134 citations

Review: Modulation of chromatin structure by poly(ADP-ribosyl)ation

1988 • 131 citations

Noncovalent interactions of poly(adenosine diphosphate ribose) with histones

1992 • 126 citations

ADP-ribosyl protein lyase. Purification, properties, and identification of the product.

1984 • 123 citations

A cellular survival switch: poly(ADP‐ribosyl)ation stimulates DNA repair and silences transcription

2001 • 122 citations

Antioxidant and pro-oxidant effects of tannins in digestive cells of the freshwater mussel Unio tumidus

2003 • 121 citations

Identification of a Novel Human Tankyrase through Its Interaction with the Adaptor Protein Grb14

2001 • 118 citations

Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis

2001 • 116 citations

Targeting PCSK9 for Hypercholesterolemia

2013 • 115 citations

tej Defines a Role for Poly(ADP-Ribosyl)ation in Establishing Period Length of the Arabidopsis Circadian Oscillator

2002 • 112 citations

Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated

2002 • 111 citations

Diagnostic Value of Postprandial Triglyceride Testing in Healthy Subjects:A Meta-Analysis

2011 • 110 citations

Role of poly(ADP-ribose)synthetase in inflammation

1998 • 106 citations

Poly(ADP‐ribose) and carcinogenesis

2003 • 96 citations

Stimulation of poly(ADP-ribosyl)ation during Ehrlich ascites tumor cell "starvation" and suppression of concomitant DNA fragmentation by benzamide.

1983 • 96 citations

Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.

2001 • 91 citations

Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

2001 • 90 citations

Poly(ADP-ribose) molecules formed during DNA repair in vivo

1994 • 90 citations

Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

2002 • 87 citations

Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.

1993 • 79 citations

Characterization of sPARP-1

2000 • 79 citations

The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death

2000 • 77 citations

Specific Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol

1995 • 74 citations

Poly(ADP-ribose) Polymerase Localizes to the Centrosomes and Chromosomes

2000 • 70 citations

Proprotein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies for Acute Coronary Syndrome

2016 • 70 citations

ODYSSEY MONO: Effect of Alirocumab 75 Mg Subcutaneously Every 2 Weeks As Monotherapy Versus Ezetimibe Over 24 Weeks

2015 • 64 citations

Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)

2003 • 62 citations

ADP-ribosylation of ADPR-transferase and topoisomerase I in intact mouse epidermal cells JB6

1989 • 61 citations

Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases

2003 • 56 citations

Different Basal NAD Levels Determine Opposite Effects of Poly(ADP-Ribosyl)Polymerase Inhibitors on H2O2-Induced Apoptosis

1995 • 55 citations

Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells.

1987 • 51 citations

Role of (ADP-ribose)nCatabolism in DNA Repair

1997 • 49 citations

Preferential Perinuclear Localization of Poly(ADP-ribose) Glycohydrolase

1999 • 49 citations

Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells.

2003 • 48 citations

Isolation and Cloning of Rat Poly(ADP-Ribose) Glycohydrolase: Presence of a Potential Nuclear Export Signal Conserved in Mammalian Orthologs

1999 • 48 citations

Alteration of poly(ADP‐ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases

2003 • 47 citations

An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase

1990 • 46 citations

Isolation and purification of poly(ADP‐ribose) glycohydrolase from pig thymus

1983 • 46 citations

Structure of a poly (adenosine diphosphoribose) monomer: 2'-(5"-hosphoribosyl)-5'-adenosine monophosphate.

1978 • 45 citations

Purification of Poly(ADP-Ribose) Glycohydrolase and Detection of Its Isoforms by a Zymogram Following One- or Two-Dimensional Electrophoresis

1994 • 45 citations

Purification and properties of an (ADP-ribose)n glycohydrolase from guinea pig liver nuclei.

1986 • 43 citations

Evidence for two variants of poly(adenosine diphosphate ribose) glycohydrolase in rat testis

1976 • 41 citations

Poly(ADP-ribose) degradation by glycohydrolase starts with an endonucleolytic incision.

1988 • 37 citations

Poly(ADP-ribose) Glycohydrolase Is Present and Active in Mammalian Cells as a 110-kDa Protein

1999 • 36 citations

Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase.

1988 • 36 citations

Biochemical properties and function of poly(ADP-ribose) glycohydrolase

1995 • 36 citations

Cytoprotective effect of gallotannin in oxidatively stressed HaCaT keratinocytes: the role of poly(ADP‐ribose) metabolism

2004 • 35 citations

Poly(ADP‐ribose) glycohydrolase in mouse fibroblast cells (LS cells)

1973 • 34 citations

Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase

1999 • 32 citations

Preferential degradation of protein-bound (ADP-ribose)n by nuclear poly(ADP-ribose) glycohydrolase from human placenta.

1993 • 32 citations

Poly (ADP‐ribose) polymerase inhibits DNA replication by human replicative DNA polymerase α, δ and ε in vitro

1994 • 31 citations

Reconstitution of an in vitro poly(ADP-ribose) turnover system

1990 • 31 citations

Purification and characterization of an (ADP‐ribose)n glycohydrolase from human erythrocytes

1990 • 31 citations

Identification of an Inhibitor Binding Site of Poly(ADP-ribose) Glycohydrolase

2003 • 30 citations

UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase

2003 • 30 citations

Assignment<footref rid="foot01"><sup>1</sup></footref> of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization

1999 • 27 citations

Rat liver mitochondrial ADP-ribose pyrophosphatase in the matrix space with low Km for free ADP-ribose

1994 • 26 citations

Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells

1997 • 25 citations

Tannins elevate the level of poly(ADP–ribose) in HeLa cell extracts

2004 • 25 citations

Poly(ADP-ribose) degradation by post-nuclear extracts from human cells

2002 • 25 citations

Characterization of two forms of poly(ADP-ribose) glycohydrolase in guinea pig liver

1991 • 21 citations

Changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases during the differentiation of human promyelocytic leukemia cell line HL-60

2003 • 21 citations

Identification of two activities of (ADP-ribose)n glycohydrolase in Hela S3 cells

1986 • 20 citations

Inhibitory effect of tannin on poly(ADP-ribose) glycohydrolase from human placenta.

1989 • 17 citations

Effects of chemically defined tannins on poly (ADP-ribose) glycohydrolase activity.

1991 • 15 citations

Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells

2003 • 13 citations

Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia

2012 • 12 citations

Properties of Poly(ADP-ribose) Glycohydrolase Purified from Pig Testis Nuclei

1996 • 12 citations

Occurrence of (ADP-ribose)n glycohydrolase in human erythrocytes

1986 • 11 citations

Lignin inhibits (ADP-ribose)n glycohydrolase activity.

1989 • 8 citations

Purification and Properties of Two Forms of Poly(ADP-Ribose) Glycohydrolase

1989 • 3 citations