Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Matrix Elasticity Directs Stem Cell Lineage Specification

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Molecular mechanisms and clinical applications of angiogenesis

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Fibroblasts in cancer

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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

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Delivering nanomedicine to solid tumors

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Targeting hypoxia in cancer therapy

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

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Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

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AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

2007 • 1,742 citations

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

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Normalization of the Vasculature for Treatment of Cancer and Other Diseases

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Determinants of tumor blood flow: a review.

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

2011 • 1,191 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

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Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

2004 • 1,160 citations

Role of extracellular matrix assembly in interstitial transport in solid tumors.

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Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

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Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

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Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

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Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

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Solid stress inhibits the growth of multicellular tumor spheroids

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Cancer cells compress intratumour vessels

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Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

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Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

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Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

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Effect of Vascular Normalization by Antiangiogenic Therapy on Interstitial Hypertension, Peritumor Edema, and Lymphatic Metastasis: Insights from a Mathematical Model

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Malignant cells facilitate lung metastasis by bringing their own soil

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Mechanical compression drives cancer cells toward invasive phenotype

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Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

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Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

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Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

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Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition

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A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients

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Degradation of Fibrillar Collagen in a Human Melanoma Xenograft Improves the Efficacy of an Oncolytic Herpes Simplex Virus Vector

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Transport of fluid and macromolecules in tumors

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Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.

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Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

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Solid stress generated by spheroid growth estimated using a linear poroelasticity model☆

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Interstitial hypertension in human breast and colorectal tumors.

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Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

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How Tumors Make Bad Blood Vessels and Stroma

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Interstitial hypertension in superficial metastatic melanomas in humans.

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Tumor angiogenesis and interstitial hypertension.

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The significance of the “tissue pressure” of normal testicular and of neoplastic (Brown‐Pearce carcinoma) tissue in the rabbit

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Compatibility and the genesis of residual stress by volumetric growth

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Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

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Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.

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Scaling rules for diffusive drug delivery in tumor and normal tissues

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Interstitial Stress and Fluid Pressure Within a Growing Tumor

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Transmural Coupling of Fluid Flow in Microcirculatory Network and Interstitium in Tumors

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In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

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Gene Expression Profiles in 3D Tumor Analogs Indicate Compressive Strain Differentially Enhances Metastatic Potential

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Residual stress in the adult mouse brain

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Solid stress facilitates spheroid formation: potential involvement of hyaluronan

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Appraising the Current Role of Chemotherapy for the Treatment of Sarcoma

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Lack of General Correlation between Interstitial Fluid Pressure and Oxygen Partial Pressure in Solid Tumors

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Image-based biomechanics of collagen-based tissue equivalents

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How Matrix Properties Control the Self-Assembly and Maintenance of Tissues

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Left Ventricular Geometric Remodeling and Residual Stress in the Rat Heart

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