Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

2009 • 2,296 citations

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

2001 • 2,069 citations

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

2004 • 1,935 citations

AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

2007 • 1,742 citations

Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

2008 • 1,520 citations

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

2011 • 1,418 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

2004 • 1,176 citations

Cancer cells compress intratumour vessels

2004 • 781 citations

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

2011 • 662 citations

Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling

1997 • 593 citations

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

2011 • 582 citations

Effect of Vascular Normalization by Antiangiogenic Therapy on Interstitial Hypertension, Peritumor Edema, and Lymphatic Metastasis: Insights from a Mathematical Model

2007 • 582 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiationRole of oxygenation, angiopoietin-1, and matrix metalloproteinases

2004 • 549 citations

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

2010 • 502 citations

A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients

2009 • 381 citations

Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice

2009 • 299 citations

Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

1996 • 179 citations

A Fully Automated Method for Quantitative Cerebral Hemodynamic Analysis Using DSC–MRI

2010 • 128 citations

Mini-review: Overcoming tumor-intrinsic resistance to immune effector function

2004 • 71 citations

Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma

2011 • 47 citations