Transforming Growth Factor‐β CD4⁺ T cells Tumor‐bearing state Immunosuppression Enhanced Production of TGF‐β and a Progressive Increase in TGF‐β Susceptibility of Anti‐tumor CD4⁺ T Cell Function

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 1,046 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens

1974 • 651 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

1986 • 381 citations

Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts.

1976 • 339 citations

EVIDENCE OF SUPPRESSOR CELL ACTIVITY IN SPLEENS OF MICE BEARING PRIMARY TUMORS INDUCED BY MOLONEY SARCOMA VIRUS

1974 • 325 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex.

1989 • 225 citations

Regulation of the Immune Response to Tumor Antigens

1976 • 207 citations

Suppressor Cells: Permitters and Promoters of Malignancy?

1979 • 162 citations

Immunosuppression and the Role of Suppressive Factors in Cancer

1977 • 162 citations

Enhancing T lymphocytes from tumor‐bearing mice suppress host resistance to a syngeneic tumor

1974 • 135 citations

The transforming growth factors

1985 • 134 citations

Comparison of intra- and extracellular transforming growth factors from nontransformed and chemically transformed mouse embryo cells.

1983 • 132 citations

T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation.

1976 • 120 citations

T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases.

1981 • 118 citations

Requirement for recognition of class II molecules and processed tumor antigen for optimal generation of syngeneic tumor-specific class I-restricted CTL.

1986 • 97 citations

Bacterial cell wall-induced immunosuppression. Role of transforming growth factor beta.

1988 • 93 citations

BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation.

1986 • 92 citations

Enhanced production of interleukin‐6 in mice with type II collagen–induced arthritis

1989 • 73 citations

Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.

1992 • 69 citations

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

1990 • 67 citations

Tolerance induction of allo-class I H-2 antigen-reactive Lyt-2+ helper T cells and prolonged survival of the corresponding class I H-2-disparate skin graft.

1989 • 59 citations

Tumor-Associated Blocking Factors: Isolation from Sera of Tumor-Bearing Mice

1976 • 56 citations

Significance of Suppressor Macrophages for Immunosurveillance of Tumor-Bearing Mice<xref ref-type="fn" rid="FN2">2</xref>

1987 • 43 citations

Studies on macrophage-activating factor (MAF) in antitumor immune responses. I. Tumor-specific Lyt-1+2- T cells are required for producing MAF able to generate cytolytic as well as cytostatic macrophages.

1985 • 36 citations

Tolerance induction of allo-class II H-2 antigen-reactive L3T4+ helper T cells and prolonged survival of the corresponding class II H-2-disparate skin graft.

1989 • 31 citations

Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts.

1991 • 27 citations

The Activation of L3T4+ Helper T Cells Assisting the Generation of Anti-Tumor Lyt-2+ Cytotoxic T Lymphocytes: Requirement of 1a-Positive Antigen-Presenting Cells for Processing and Presentation of Tumor Antigens

1987 • 26 citations

Immune Dysfunction Expressed Selectively on L3T4+ T Cells in the Tumor-Bearing State

1990 • 18 citations

Significance of suppressor macrophages for immunosurveillance of tumor-bearing mice

1987 • 12 citations

The mode of recognition of tumor antigens by noncytolytic-type antitumor T cells: Role of antigen-presenting cells and their surface class I and class II H-2 molecules

1988 • 9 citations

Inhibitory effect of tumor-bearing state on the generation of in vivo protective immune T cells in a syngeneic murine tumor system.

1977 • 9 citations