N-Acetylcysteine-promoted Survival of PC12 Cells Is Glutathione-independent but Transcription-dependent

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1978 • 431 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

1994 • 373 citations

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.

1991 • 359 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

1995 • 273 citations

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.

1994 • 271 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

The role of estrogens on the proliferation of human breast tumor cells (MCF-7)

1985 • 257 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons.

1992 • 221 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

Internucleosomal DNA cleavage and neuronal cell survival/death

1993 • 194 citations

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.

1979 • 173 citations

Metabolic activation and hepatotoxicity

1979 • 158 citations

Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-κB in vitro

1994 • 153 citations

The cell cycle and cell death

1993 • 137 citations

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of Ca2+-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death

1992 • 127 citations

[48] N-acetylcysteine

1994 • 115 citations

Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death.

1994 • 103 citations

Effects of N-acetyl-l-cysteine on T-cell apoptosis are not mediated by increased cellular glutathione

1995 • 103 citations

Gangliosides rescue neuronal cells from death after trophic factor deprivation.

1993 • 79 citations

Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins.

1994 • 72 citations

Gangliosides rescue neuronal cells from death after trophic factor deprivation

1993 • 65 citations

Purine analogs inhibit nerve growth factor-promoted neurite outgrowth by sympathetic and sensory neurons

1990 • 58 citations

The Redox Active Components H202 and N-AcetyI-L-Cysteine Regulate Expression of c-jun and c-fos in Lens Systems

1994 • 54 citations

Role of growth factors in degeneration and regeneration in the central nervous system; clinical experiences with NGF in Parkinson's and Alzheimer's diseases

1994 • 52 citations

Effects of 2-mercaptoethanol on survival and differentiation of fetal mouse brain neurons cultured in vitro

1993 • 47 citations

Characterization of antisera raised against cultured rat sympathetic neurons

1980 • 36 citations

Sulfhydryl drugs reduce neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridime (MPTP) in the mouse

1993 • 31 citations

2-Mercaptoethanol is a survival factor for olfactory, cortical and hippocampal neurons in short-term dissociated cell culture

1993 • 29 citations

Development of effective therapy for Alzheimer's disease based on neurotrophic factors

1994 • 28 citations

Effects of 2-mercaptoethanol and buthionine sulfoximine on cystine metabolism by and proliferation of mitogen-stimulated human and mouse lymphocytes

1992 • 25 citations