Aging, Longevity, Inflammation, and Cancer

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

2000 • 4,521 citations

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER

1997 • 1,730 citations

Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

1996 • 1,031 citations

The age of cancer

2000 • 949 citations

Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms

2003 • 908 citations

Cytokine gene polymorphism in human disease: on-line databases

1999 • 831 citations

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

2002 • 793 citations

Aging and proinflammatory cytokines

2001 • 681 citations

IL-6 signal transduction and its physiological roles: the signal orchestration model

2003 • 673 citations

C-Reactive Protein and the Risk of Incident Colorectal Cancer

2004 • 543 citations

Polymorphic haplotypes of the interleukin-10 5? flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis

1999 • 543 citations

The immunology of exceptional individuals: the lesson of centenarians

1995 • 538 citations

Systemic inflammatory response predicts survival following curative resection of colorectal cancer

2003 • 446 citations

T cells and aging january 2002 update

2002 • 368 citations

Influence of cytokine gene polymorphisms on the development of prostate cancer.

2002 • 342 citations

Serum interleukin‐6 levels reflect the disease status of colorectal cancer

2003 • 337 citations

Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer.

2003 • 319 citations

A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity

2001 • 314 citations

Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients

2003 • 299 citations

Cytokine gene polymorphism in human disease: on-line databases, Supplement 1

2001 • 278 citations

Tumors and inflammatory infiltrates: friends or foes?

2002 • 233 citations

Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms1

2003 • 225 citations

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

2002 • 221 citations

Interleukin-6 Blood Level Is Associated With Circulating Carcinoembryonic Antigen and Prognosis in Patients With Colorectal Cancer

2000 • 192 citations

Geriatric oncology

2003 • 180 citations

Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells.

1999 • 162 citations

Regulation of Tumor Growth and Metastasis by Interleukin-10: The Melanoma Experience

1999 • 161 citations

Interleukin-6 -174G-->C polymorphism is associated with improved outcome in high-risk breast cancer.

2003 • 153 citations

Cardiovascular Advantages Among the Offspring of Centenarians

2003 • 152 citations

IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma

2001 • 146 citations

Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma

2003 • 142 citations

Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma

1995 • 138 citations

Allele frequencies of polymorphisms of the tumour necrosis factor‐α, interleukin‐10, interferon‐γ and interleukin‐2 genes in a North European Caucasoid group from the UK

2000 • 134 citations

Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease

2003 • 126 citations

IL-10 as a mediator in the HPA axis and brain

1999 • 121 citations

Extracellular Signal-Regulated Kinase, Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase, and p38mapkAre Involved in IL-10-Mediated Selective Repression of TNF-α-Induced Activation and Maturation of Human Peripheral Blood Monocyte-Derived Dendritic Cells

1999 • 121 citations

Cancer of the Oldest Old: What we Have Learned from Autopsy Studies

1997 • 104 citations

HLA-G and IL-10 expression in human cancer—different stories with the same message

2003 • 104 citations

Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-α genes in Finnish nonagenarians

2001 • 94 citations

-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer.

2003 • 90 citations

Unregulated inflammation shortens human functional longevity

2000 • 88 citations

Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians

2004 • 88 citations

HLA, aging, and longevity: a critical reappraisal

2000 • 85 citations

An interleukin-6 gene promoter polymorphism influences the biological phenotype of ovarian cancer.

2003 • 85 citations

Gene polymorphisms, inflammatory diseases and cancer

2002 • 84 citations

Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants

2003 • 83 citations

Is human immunosenescence clinically relevant? Looking for ‘immunological risk phenotypes’

2002 • 79 citations

Symposium on ’Nutrition in the post-genomic era’ Plenary session 4: Genetic variation and diet-related disease

2002 • 76 citations

Association of Breast Cancer and Polymorphisms of Interleukin-10 and Tumor Necrosis Factor-α Genes

2003 • 71 citations

Study of age-association with cytokine gene polymorphisms in an aged Irish population

2003 • 70 citations

What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians

2002 • 70 citations

Regulation of ICAM‐1 (CD54) expression in human breast cancer cell lines by interleukin 6 and fibroblast‐derived factors

1994 • 67 citations

The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype

2004 • 67 citations

Expression of and response to interleukin 6 (IL6) in human mammary tumors.

1996 • 60 citations

Expression of interleukin-6, interleukin-6 receptor, and glycoprotein 130 correlates with good prognoses for patients with breast carcinoma

2000 • 57 citations

Expression of interleukin 6 (IL-6) correlates with oestrogen receptor in human breast carcinoma

1999 • 56 citations

Cancer incidence in old age

2000 • 48 citations

Cancer and Aging: From the Kinetics of Biological Parameters to the Kinetics of Cancer Incidence and Mortalitya

1988 • 47 citations

Interleukin-10, interleukin-6 and interferon-γ gene polymorphisms in melanoma patients

2002 • 45 citations

Immunological markers contributing to successful aging in Bulgarians

2004 • 38 citations

Immunological and immunogenetic markers of successful and unsuccessful ageing

2002 • 23 citations

Resistance to Causes of Death: A Study of Cancer Mortality Resistance in the Oldest Old

1999 • 13 citations

Chronic antigenic stress, immunosenescence and human survivorship over the 3 last centuries: heuristic value of a mathematical model

2003 • 11 citations