Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-α genes in Finnish nonagenarians

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER

1997 • 1,730 citations

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly∗∗Access the “Journal Club” discussion of this paper at http:/www.elsevier.com/locate/ajmselect/

1999 • 1,467 citations

The Aging Immune System: Primer and Prospectus

1996 • 1,166 citations

Genetic associations with human longevity at the APOE and ACE loci

1994 • 1,079 citations

A Taql polymorphism in the human interleukin‐1β (IL‐1β) gene correlates with IL‐1β secretion in vitro

1992 • 923 citations

Single base polymorphism in the human Tumour Necrosis Factor alpha (TNFα) gene detectable by Ncol restriction of PCR product

1992 • 903 citations

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

1993 • 688 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1995 • 543 citations

Presence of the IL‐1RA Allele 2 (IL1RN*2) is Associated with Enhanced IL‐1β Production In Vitro

1998 • 543 citations

The immunology of exceptional individuals: the lesson of centenarians

1995 • 538 citations

Genetics of Aging

1997 • 493 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes

1998 • 435 citations

Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease.

1997 • 414 citations

Increase of plasma IL-6 concentration with age in healthy subjects

1992 • 393 citations

Mapping of the human IL10 gene and further characterization of the 5' flanking sequence

1997 • 389 citations

A polymorphic variation in a putative regulation box of the TNFA promoter region

1994 • 362 citations

Single base polymorphism at −511 in the human interleukin-1β gene (IL1β)

1992 • 357 citations

A genetic association between juvenile rheumatoid arthritis and a novel interleukin‐1α polymorphism

1995 • 327 citations

Interleukin-1?, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: Relationship to occurrence and severity of rheumatoid arthritis

1999 • 264 citations

Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease

1999 • 229 citations

A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease

1999 • 190 citations

An Analysis of Linkage Disequilibrium in the Interleukin-1 Gene Cluster, Using a Novel Grouping Method for Multiallelic Markers

1998 • 182 citations

Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production

1998 • 174 citations

ACE Gene Polymorphism: Ischemic Heart Disease and Longevity in 10 150 Individuals

1997 • 171 citations

Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep

1995 • 170 citations

Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus

1996 • 150 citations

IL-10 Gene Promoter Polymorphisms in Rheumatoid Arthritis: SHORT REPORT

1998 • 146 citations

Declining physical abilities with age: a cross-sectional study of older twins and centenarians in Denmark

1999 • 144 citations

Apolipoprotein E and B polymorphisms - longevity factors assessed in nonagenarians

1994 • 143 citations

Genes, Demography, and Life Span: The Contribution of Demographic Data in Genetic Studies on Aging and Longevity

1999 • 140 citations

IL-1 Receptor Antagonist (IL-1RA) Gene Polymorphism in Sjogren's Syndrome and Rheumatoid Arthritis

1998 • 112 citations

Changes in Lymphocyte Subsets, Interleukin 2, and Soluble Interleukin 2 Receptor in Old and Very Old Age

1996 • 110 citations

Gene Polymorphisms Predicting High Plasma Levels of Coagulation and Fibrinolysis Proteins

1997 • 107 citations

AKEntAnnos. The Sardinia Study of Extreme Longevity

1999 • 96 citations

HLA and longevity

1982 • 91 citations

A novel NlaIII polymorphism in the human IL‐6 promoter

1998 • 88 citations

Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cy/Arg, and its stability in a population of Finnish centenarians

1999 • 84 citations

Exercise, immunity and aging

1997 • 77 citations

Rapid detection and sequencing of alleles in the 3′ flanking region of the Interleukin-6 gene

1989 • 77 citations

A novel NlaIII polymorphism in the human IL-6 promoter

1998 • 68 citations

The familial component in longevity. A study of offspring of nonagenarians. II. Preliminary analysis of the completed study.

1974 • 64 citations

DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus

1997 • 63 citations

AN INTERLUEKIN 1B ALLELE, WHICH CORRELATES WITH A HIGH SECRETOR PHENOTYPE, IS ASSOCIATED WITH DIABETIC NEPHROPATHY

1998 • 56 citations

Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians.

1998 • 56 citations

Causes, Effects, and Constraints in the Genetics of Human Longevity

1998 • 55 citations

Polymorphism of the IL‐1 Gene Complex in Epstein–Barr Virus Seronegative and Seropositive Adult Blood Donors

1998 • 50 citations

Apolipoprotein E Polymorphism Is Not Associated with Longevity or Disability in a Sample of Italian Octo- and Nonagenarians

1998 • 49 citations

Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians

1998 • 47 citations

Apolipoprotein E and longevity among Han Chinese population

1998 • 46 citations

In search of a biological pattern for human longevity: Impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians

1998 • 45 citations

Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci

1998 • 40 citations

Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity

1997 • 35 citations

Functional status and need of help among people aged 90 or over: a mailed survey with a total home-dwelling population

1999 • 34 citations

Genes and longevity

1996 • 10 citations

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