A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

2000 • 1,753 citations

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly∗∗Access the “Journal Club” discussion of this paper at http:/www.elsevier.com/locate/ajmselect/

1999 • 1,467 citations

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

1998 • 1,463 citations

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

2000 • 1,245 citations

Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation

2000 • 802 citations

Serum IL‐6 Level and the Development of Disability in Older Persons

1999 • 799 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women

2001 • 431 citations

Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans

1999 • 385 citations

Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation

2000 • 351 citations

A Monte Carlo method for combined segregation and linkage analysis.

1992 • 301 citations

Interleukin-6 gene polymorphism and insulin sensitivity.

2000 • 249 citations

Do men and women follow different trajectories to reach extreme longevity?

2000 • 238 citations

Stromelysin-1 and Interleukin-6 Gene Promoter Polymorphisms Are Determinants of Asymptomatic Carotid Artery Atherosclerosis

2000 • 212 citations

Interleukin-6 Gene Polymorphism and Lipid Abnormalities in Healthy Subjects

2000 • 209 citations

Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors

1998 • 184 citations

Circulating levels of interleukin-6, its soluble receptor and interleukin-6/interleukin-6 receptor complexes in patients with type 2 diabetes mellitus

1999 • 158 citations

Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans

1999 • 155 citations

Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)

1998 • 117 citations

Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status

1998 • 108 citations

The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors

1999 • 104 citations

A novel NlaIII polymorphism in the human IL‐6 promoter

1998 • 88 citations

A novel NlaIII polymorphism in the human IL-6 promoter

1998 • 68 citations

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