Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

2000 • 1,245 citations

Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation

2000 • 802 citations

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

Aging and proinflammatory cytokines

2001 • 681 citations

Cytokines and autoimmunity

2002 • 663 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

2001 • 408 citations

Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation

1998 • 406 citations

The interleukin-6 −174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men

2001 • 406 citations

New insights into the biology of the acute phase response.

1999 • 389 citations

Increased tumor necrosis factor alpha (TNF alpha), interleukin 1, and interleukin 6 (IL‐6) levels in the plasma of stored platelet concentrates: relationship between TNF alpha and IL‐6 levels and febrile transfusion reactions

1993 • 372 citations

Interleukin-6 ( IL-6 ) and the Prognosis of Abdominal Aortic Aneurysms

2001 • 368 citations

A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity

2001 • 314 citations

Peripheral Blood Markers of Inflammation Predict Mortality and Functional Decline in High‐Functioning Community‐Dwelling Older Persons

2002 • 298 citations

Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

2002 • 261 citations

Relation of the −174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization

2001 • 183 citations

Interleukin-6 −174G>C Polymorphism and Risk of Coronary Heart Disease in West of Scotland Coronary Prevention Study (WOSCOPS)

2002 • 179 citations

The role of interleukin-6 in the failing heart.

2001 • 178 citations

Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis

2002 • 176 citations

Influence of collection and separation of blood samples on plasma IL-1, IL-6 and TNF-α concentrations

1992 • 136 citations

The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults.

2001 • 135 citations

Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women

2002 • 112 citations

A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women

2001 • 98 citations

The −174 C/G locus affects in vitro/in vivo IL-6 production during aging

2002 • 96 citations

Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-α genes in Finnish nonagenarians

2001 • 94 citations

A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction

2002 • 92 citations

Neuroinflammation and the genetics of Alzheimer’s disease: The search for a pro-inflammatory phenotype

2001 • 86 citations

The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population

2001 • 76 citations

A whole blood method for measurement of intracellular TNF-α, IFN-γ and IL-2 expression in stimulated CD3+ lymphocytes: differences between young and elderly subjects

2002 • 71 citations

Study of age-association with cytokine gene polymorphisms in an aged Irish population

2003 • 70 citations

The effect of the Interleukin‐6–174G > C promoter gene polymorphism on endothelial function in healthy volunteers

2002 • 50 citations

Interleukin‐10 Directly Inhibits the Interleukin‐6 Production in T‐Cells

1995 • 44 citations

A novel single nucleotide polymorphism and five probable haplotypes in the 5′ flanking region of the IL-6 gene in African-Americans

1999 • 40 citations

LONG‐RANGE PCR AMPLIFICATION AS AN ALTERNATIVE STRATEGY FOR CHARACTERIZING NOVEL HLA‐B ALLELES

1996 • 33 citations

Regulation of Interleukin-6 Secretion from Mononuclear Blood Cells by Extracellular Calcium

1997 • 31 citations

Community-living nonagenarians in Northern Ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70–89-year-old subjects

2000 • 28 citations

THE DIMINISHED POSTOPERATIVE CAPACITY OF BLOOD LEUKOCYTES TO PRODUCE IL-6 IS ASSOCIATED WITH HIGH CONCENTRATIONS OF IL-6 IN THE CIRCULATION

2000 • 12 citations

Advances in molecular diagnosis of inherited hemoglobin disorders

1996 • 9 citations

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1997 • 8 citations

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