Angiogenesis and the skin: A primer

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Angiogenic Factors

1987 • 3,702 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Angiogenesis.

1992 • 2,581 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 • 1,273 citations

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein.

1984 • 1,249 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Regulators of Angiogenesis

1991 • 959 citations

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

1994 • 903 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Long-term culture of capillary endothelial cells.

1979 • 780 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1989 • 726 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

1990 • 689 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor

1989 • 673 citations

Cellular markers that distinguish the phases of hemangioma during infancy and childhood.

1994 • 651 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

1992 • 552 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Fibronectin controls capillary endothelial cell growth by modulating cell shape.

1990 • 498 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny

1989 • 460 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

1995 • 442 citations

IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.

1993 • 411 citations

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

1994 • 400 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

13-cis-Retinoic Acid and Interferon -2a: Effective Combination. Therapy for Advanced Squamous Cell Carcinoma of the Skin

1992 • 389 citations

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

1988 • 386 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.

1994 • 364 citations

Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.

1994 • 357 citations

Diverse forms of a receptor for acidic and basic fibroblast growth factors.

1990 • 352 citations

Induction of vasculogenesis and hematopoiesis in vitro

1992 • 345 citations

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

1993 • 334 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

The "trap" hypothesis of venous ulceration

1993 • 326 citations

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

1991 • 324 citations

Heparanases and tumor metastasis

1988 • 303 citations

Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.

1989 • 270 citations

The Current Management of Vascular Birthmarks

1993 • 269 citations

Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth

1991 • 260 citations

Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis

1990 • 253 citations

Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells

1992 • 251 citations

Induced expression of syndecan in healing wounds.

1991 • 249 citations

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy

1995 • 243 citations

bFGF as an autocrine growth factor for human melanomas.

1988 • 237 citations

Topical Use of Human Recombinant Epidermal Growth Factor (h‐EGF) in Venous Ulcers

1992 • 226 citations

Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia.

1994 • 214 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials

1994 • 214 citations

Role of the Microcirculation in the Treatment and Pathogenesis of Psoriasis

1982 • 193 citations

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

1993 • 192 citations

Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis.

1994 • 190 citations

Isolation and Growth of Endothelial Cells from the Microvessels of the Newborn Human Foreskin in Cell Culture

1980 • 177 citations

Growth of normal human keratinocytes and fibroblasts in serum‐free medium is stimulated by acidic and basic fibroblast growth factor

1989 • 174 citations

Angiogenesis and tumor progression of melanoma. Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma.

1992 • 173 citations

Fibroblast Growth Factor

1990 • 173 citations

Stimulation of Growth of Keratinocytes by Basic Fibroblast Growth Factor

1988 • 172 citations

Modes of FGF release in vivo and in vitro

1990 • 169 citations

Leg ulcers

1991 • 163 citations

Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.

1992 • 162 citations

Basic Fibroblast Growth Factor Stimulation of Epidermal Wound Healing in Pigs

1990 • 145 citations

Growth factors induce 3T3 cells to express bFGF-binding syndecan.

1992 • 138 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials.

1994 • 136 citations

Central retinal artery occlusion associated with periocular corticosteroid injection for juvenile hemangioma.

1986 • 129 citations

Human Keratinocytes Express the Three Major Splice Forms of Vascular Endothelial Growth Factor

1995 • 127 citations

Developmental expression of the syndecans: possible function and regulation

1993 • 112 citations

Expression of monocyte chemotactic protein-1 in human melanoma in vivo.

1992 • 112 citations

Thalidomide: Use and possible mode of action in reactional lepromatous leprosy and in various other conditions

1982 • 111 citations

Central Retinal Artery Occlusion Associated With Periocular Corticosteroid Injection for Juvenile Hemangioma

1986 • 105 citations

Endothelial cell markers in vascular neoplasms: An immunohistochemical study comparing factor VIII‐related antigen, blood group specific antigens, 6‐keto‐PGF1 alpha, and Ulex europaeus 1 lectin

1986 • 103 citations

AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle.

1994 • 97 citations

Expression and Secretion of Leukocyte Chemotactic Cytokines by Normal Human Melanocytes and Melanoma Cells

1991 • 96 citations

Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins.

1992 • 87 citations

Treatment of neoplastic skin lesions with intralesional interferon

1989 • 81 citations

Angiogenic properties of normal and psoriatic skin associate with epidermis, not dermis.

1989 • 78 citations

Oncostatin-M is an autocrine growth factor in Kaposi's sarcoma.

1994 • 76 citations

The Effect of an Intralesional Sustained-Release Formulation of Interferon Alfa-2b on Basal Cell Carcinomas

1990 • 74 citations

Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development.

1992 • 67 citations

A preliminary three-dimensional structure of angiogenin.

1986 • 67 citations

Treatment of aggressive basal cell carcinoma with intralesional interferon: Evaluation of efficacy by Mohs surgery

1992 • 62 citations

Beta-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation.

1993 • 60 citations

Intralesional interferon alfa-2b in the treatment of basal cell carcinoma

1991 • 59 citations

Acidic Fibroblast Growth Factor Accelerates Dermal Wound Healing

1992 • 54 citations

The application of immunohistochemical stains to identify endothelial-lined channels in mammary carcinoma

1987 • 44 citations

Nonsurgical Treatments for Skin Cancer: Retinoids and α‐Interferon

1988 • 42 citations

Development of angiogenesis inhibitors for clinical applications

1990 • 37 citations

Isolation and characterization of microvascular endothelial cells from the adult human dermis and from skin biopsies of patients with systemic sclerosis.

1994 • 35 citations

Clinical experience with the combined use of recombinant interleukin‐2 (IL2) and interferon alfa‐2a (IFNα) in metastatic melanoma

1991 • 34 citations

Disaccharide Composition of Heparan Sulfates: Brain, Nervous Tissue Storage Organelles, Kidney, and Lung

1994 • 27 citations

Interferon

1990 • 14 citations

Chemical and Biochemical Properties of Human Angiogenin

1988 • 10 citations

Treatment of Neoplastic Skin Lesions with Intralesional Interferon. By L. Wickramasinghe, T. C. Hindson, and H. Wacks. J Am Acad Dermatol 1989;20

1989 • 4 citations