A targeted DNA vaccine encoding Fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Glutamate excitotoxicity in a model of multiple sclerosis

2000 • 832 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Multiple Sclerosis

1982 • 415 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes.

1996 • 381 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.

1993 • 305 citations

Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain.

1996 • 283 citations

Identification of the Integral Membrane Protein RM3/1 on Human Monocytes as a Glucocorticoid-Inducible Member of the Scavenger Receptor Cysteine-Rich Family (CD163)

1998 • 247 citations

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

1997 • 238 citations

Multiple sclerosis: Oligodendrocytes display cell death–related molecules in situ but do not undergo apoptosis

1997 • 204 citations

Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.

1997 • 204 citations

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

1993 • 192 citations

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

1995 • 177 citations

Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system.

1997 • 155 citations

Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis.

1998 • 147 citations

Dual Role for Fas Ligand in the Initiation of and Recovery from Experimental Allergic Encephalomyelitis

1999 • 137 citations

Cell death during autoimmune demyelination: effector but not target cells are eliminated by apoptosis.

1997 • 134 citations

Long-Lasting Protective Immunity to Experimental Autoimmune Encephalomyelitis Following Vaccination with Naked DNA Encoding C-C Chemokines

1998 • 125 citations

Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis

2000 • 124 citations

Solubilization and Functional Reconstitution of Biomembrane Components

1992 • 118 citations

Neutralizing Antibodies to IFN-γ-Inducing Factor Prevent Experimental Autoimmune Encephalomyelitis

1998 • 117 citations

LPS-induced sTNF-receptor release in vivo in a murine model. Investigation of the role of tumor necrosis factor, IL-1, leukemia inhibiting factor, and IFN-gamma.

1993 • 93 citations

Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis.

1993 • 87 citations

Prevention of Experimental Autoimmune Encephalomyelitis by MIP-1α and MCP-1 Naked DNA Vaccines

1999 • 73 citations

Augmentation of natural immunity to a pro-inflammatory cytokine (TNF-alpha) by targeted DNA vaccine confers long-lasting resistance to experimental autoimmune encephalomyelitis

1999 • 41 citations

The Role of the Antigen-Presenting Cell in Fas-Mediated Direct and Bystander Killing: Potential In Vivo Function of Fas in Experimental Allergic Encephalomyelitis

1999 • 34 citations

Blood Leucocyte Subsets of the Rat: Expression of Adhesion Molecules and Localization Within High Endothelial Venules

1996 • 13 citations

The challenge: how good a model of MS is EAE today?

1984 • 12 citations