Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Isolation and characterization of a high molecular weight glycoprotein from human blood platelets.

1978 • 428 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.

1987 • 292 citations

Angiogenesis in human coronary atherosclerotic plaques.

1994 • 273 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Thrombospondin modulates focal adhesions in endothelial cells.

1989 • 271 citations

Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix.

1983 • 266 citations

Light microscopic immunolocation of thrombospondin in human tissues.

1985 • 265 citations

Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin.

1986 • 259 citations

Thrombospondin: synthesis and secretion by cells in culture.

1982 • 259 citations

Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation

1988 • 256 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells.

1985 • 232 citations

Differential expression of thrombospondin 1, 2, and 3 during murine development

1993 • 226 citations

Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.

1993 • 217 citations

Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin.

1981 • 216 citations

Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo.

1988 • 212 citations

Monocytes and macrophages synthesize and secrete thrombospondin

1985 • 208 citations

Platelet thrombospondin mediates attachment and spreading of human melanoma cells.

1987 • 196 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor.

1987 • 139 citations

[4] Thrombospondins

1994 • 137 citations

Collagen synthesis by bovine aortic endothelial cells in culture

1979 • 137 citations

Modulation of sulfated proteoglycan synthesis by bovine aortic endothelial cells during migration.

1986 • 131 citations

Heparin-binding peptides from the type I repeats of thrombospondin. Structural requirements for heparin binding and promotion of melanoma cell adhesion and chemotaxis.

1992 • 120 citations

Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.

1992 • 115 citations

Regulation of thrombospondin secretion by cells in culture

1984 • 112 citations

The in situ localization of tenascin splice variants and thrombospondin 2 mRNA in the avian embryo

1993 • 87 citations

Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1.

1994 • 85 citations

A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.

1993 • 85 citations

A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum.

1991 • 66 citations

Thrombospondin 3 is a developmentally regulated heparin binding protein.

1994 • 64 citations

Stimulation of fibroblast proliferation by thrombospondin

1989 • 58 citations

Comparison of normal and tumorigenic endothelial cells: Differences in thrombospondin production and responses to transforming growth factor-beta

1994 • 52 citations

Thrombospondin II: Partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans

1992 • 49 citations

Thrombospondin gene expression is associated with mitogenesis in 3T3 cells: Induction by basic fibroblast growth factor

1990 • 45 citations

High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth.

1993 • 40 citations

Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1.

1992 • 40 citations

Cell attachment activity of the carboxyl-terminal domain of human thrombospondin expressed in Escherichia coli.

1991 • 36 citations

Human Platelets Contain mRNA Transcripts for Platelet Factor 4 and Actin

1989 • 24 citations